Plasma osteoprotegerin as a biomarker of poor glycaemic control that predicts progression of albuminuria in type 2 diabetes mellitus: A 3-year longitudinal cohort study

2020 ◽  
Vol 161 ◽  
pp. 107992
Author(s):  
Angela Mei Chung Moh ◽  
Sharon Li Ting Pek ◽  
Jianjun Liu ◽  
Jiexun Wang ◽  
Tavintharan Subramaniam ◽  
...  
2019 ◽  
Vol 12 (12) ◽  
pp. e232553 ◽  
Author(s):  
Tomomi Ueda ◽  
Yuya Tsurutani ◽  
Sho Katsuragawa ◽  
Jun Saito

We report a rare case of type 2 diabetes mellitus (T2DM) complicated with idiopathic hypoparathyroidism. A 36-year-old Japanese man was admitted to our hospital owing to poor glycaemic control and hypocalcaemia. The patient had myalgia resulting from hypocalcaemia, which prevented adequate exercise. He considered the onset of myalgia to be an adverse event of oral hypoglycaemic agents and reduced compliance to medication; however, his serum calcium level was never measured. Treatment for hypocalcaemia immediately improved the myalgia, facilitating regular exercise therapy and ensuring compliance with prescribed medications, as the now-resolved myalgia was no longer perceived to be an adverse effect of glucose-lowering agents; this improved glycaemic control. Although hypoparathyroidism is a rare disease, it is necessary to assess serum calcium levels in patients with T2DM, particularly in cases presenting with unidentified complaints such as myalgia.


2018 ◽  
Vol 60 (1) ◽  
pp. 45
Author(s):  
Andrew Ekene Umeh ◽  
Lushiku Nkombua

Introduction: Diabetes mellitus is one of the most common clinical conditions seen by family physicians in their daily practice. They are constantly confronted with the burden of caring for poorly controlled and poorly adherent patients presenting with preventable debilitating, disabling and mutilating complications. Lifestyle modifications in combination with medications have been proven to contribute to the prevention and delay of complications. Aims: The study aimed to investigate the knowledge and practice of lifestyle modifications and also to determine challenges faced by patients in their practice of lifestyle changes in the management of type 2 diabetes mellitus in the Middelburg subdistrict of Mpumalanga. Study design: An observational, descriptive and cross-sectional study was done. Data were collected from 150 patients with type 2 diabetes mellitus (T2DM) using a self-administered questionnaire. Results: The results showed that DM was more prevalent among females and the age group 50– 59 years was mostly affected. Nearly 50% of the respondents were obese and about 35% of them overweight. Lifestyle modification was understood as healthy dietary habits. Only 35% of the respondents participated in exercises. Brisk walking (59%) was the preferred form of exercise among these participants. A statistically significant finding was that 79.63% of participants who did not adhere to exercise recommendations had poor glycaemic control. Only 40.48% of participants who adhered to exercise recommendations had good glycaemic control. Obesity (47.52%) and overweight (32.67%) were associated with poor glycaemic control. Conclusion and recommendation: The majority of the participants thought that lifestyle modification was healthy eating; only a third of them regularly exercised. The author recommends a multidisciplinary and multilevel approach involving different stakeholders— among others, patients and community, health professionals/providers and government services—in assisting diabetic patients with lifestyle modification. (Full text of the research articles are available online at www.medpharm.tandfonline.com/ojfp) S Afr Fam Pract 2018; DOI: 10.1080/20786190.2017.1364012


2021 ◽  
pp. 106-108
Author(s):  
Charchit Mehta ◽  
Vidyasagar C R ◽  
Raveesha A

Objectives- To explore the association of Triglyceride Glucose index with HbA c and To evaluate their 1 potential role as predictors of glycemic control in patients with type 2 diabetes mellitus. Design: observational study Setting: Conducted in the Department of General Medicine at Sri Devaraj Urs medical college, Kolar, Karnataka. Subjects: 98 diabetic subjects were studied and were evaluated for predicting glycemic control using triglyceride glucose index. Results: Among subjects with good glycaemic control (HbA1c <7%) mean Triglyceride was 136 + 21.78 mg/dl and Among subjects with poor glycaemic control (HbA1c >7%) mean Triglyceride was 190.35 + 62.94 mg/dl. there was a statistically signicant difference found between Triglyceride and HbA1c. Among subjects with good glycaemic control (HbA1c <7%) mean Triglyceride glucose index was 9275.06 + 2154.22 mg/dl and Among subjects with poor glycaemic control (HbA1c >7%) mean Triglyceride glucose index was 24223.63+ 15794.73mg/dl. there was a statistically signicant difference found between Triglyceride glucose index and HbA1c Conclusion: We can use Triglyceride glucose index in predicting glycaemic control in type 2 DM which is inexpensive and cost effective.


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