In vitro activity of daptomycin against Staphylococcus aureus and vancomycin-resistant Enterococcus faecium isolates associated with skin and soft tissue infections: first results from India

2009 ◽  
Vol 65 (2) ◽  
pp. 196-198 ◽  
Author(s):  
Benu Dhawan ◽  
Ravisekhar Gadepalli ◽  
Arti Kapil
Keyword(s):  
Staphylococcus Aureus ◽  
Soft Tissue ◽  
Enterococcus Faecium ◽  
Vitro Activity ◽  
Soft Tissue Infections ◽  
Vancomycin Resistant Enterococcus ◽  
In Vitro Activity ◽  
First Results ◽  
Vancomycin Resistant

In vitro activity of fosfomycin tromethamine and linezolid against vancomycin-resistant Enterococcus faecium isolates

2008 ◽  
Vol 31 (3) ◽  
pp. 296-298 ◽  
Author(s):  
Feriha Cilli ◽  
Husnu Pullukcu ◽  
Sohret Aydemir ◽  
Oguz Resat Sipahi ◽  
Meltem Tasbakan ◽  
...  
Keyword(s):  
Enterococcus Faecium ◽  
Vitro Activity ◽  
Vancomycin Resistant Enterococcus ◽  
In Vitro Activity ◽  
Vancomycin Resistant

Synergy Testing of Vancomycin-Resistant Enterococcus faecium against Quinupristin-Dalfopristin in Combination with Other Antimicrobial Agents

1999 ◽  
Vol 43 (11) ◽  
pp. 2776-2779 ◽  
Author(s):  
S. O. Matsumura ◽  
L. Louie ◽  
M. Louie ◽  
A. E. Simor
Keyword(s):  
Clinical Evaluation ◽  
Enterococcus Faecium ◽  
Antimicrobial Agents ◽  
Vitro Activity ◽  
Vancomycin Resistant Enterococcus ◽  
In Vitro Activity ◽  
Vancomycin Resistant ◽  
Time Kill ◽  
Synergy Testing

ABSTRACT Using checkerboard and time-kill assays, we evaluated the in vitro activity of quinupristin-dalfopristin (RP 59500) alone and in combination with five other antimicrobial agents against 12 clinical strains of vancomycin-resistant Enterococcus faecium(VREF). In time-kill studies, six VREF strains exhibited synergism with the combination of quinupristin-dalfopristin and doxycycline and three exhibited synergism with quinupristin-dalfopristin plus ampicillin-sulbactam. Combinations of quinupristin-dalfopristin with these and other agents warrant further clinical evaluation for the treatment of serious VREF infections.

scholarly journals In Vitro Activities of LY333328 and Comparative Agents against Nosocomial Gram-Positive Pathogens Collected in a 1997 Global Surveillance Study

2000 ◽  
Vol 44 (5) ◽  
pp. 1370-1374 ◽  
Author(s):  
Michael L. Zeckel ◽  
David A. Preston ◽  
Bradley S. Allen
Keyword(s):  
Staphylococcus Aureus ◽  
Streptococcus Pneumoniae ◽  
Enterococcus Faecalis ◽  
Enterococcus Faecium ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Gram Positive ◽  
Vancomycin Resistant Enterococci ◽  
Vancomycin Resistant

ABSTRACT The in vitro activity of LY333328 was evaluated for 1,479 nosocomial gram-positive pathogens isolated in 12 countries during 1997. LY333328 MICs at which 90% of the isolates tested were inhibited for Enterococcus faecalis (n = 351),Enterococcus faecium (n = 100),Staphylococcus aureus (n = 593), coagulase-negative Staphylococcus species (n = 325), and Streptococcus pneumoniae(n = 110) were 1, 1, 2, 2, and 0.015 μg/ml, respectively. LY333328 demonstrated potent activity against isolates of vancomycin-resistant enterococci, oxacillin-resistant staphylococci, and penicillin-resistant pneumococci.

scholarly journals In Vitro Activity of Ceftaroline against Community-Associated Methicillin-Resistant, Vancomycin-Intermediate, Vancomycin-Resistant, and Daptomycin-Nonsusceptible Staphylococcus aureus Isolates

2010 ◽  
Vol 54 (7) ◽  
pp. 3027-3030 ◽  
Author(s):  
Louis Saravolatz ◽  
Joan Pawlak ◽  
Leonard Johnson
Keyword(s):  
Staphylococcus Aureus ◽  
Treatment Option ◽  
Bactericidal Activity ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Methicillin Resistant ◽  
Vancomycin Resistant

ABSTRACT This study assessed the in vitro activities of ceftaroline and five comparator agents against a collection of Staphylococcus aureus isolates. Ceftaroline demonstrated potent activity against community-associated methicillin-resistant S. aureus (CA-MRSA) isolates and showed bactericidal activity against vancomycin-intermediate S. aureus (VISA), vancomycin-resistant S. aureus (VRSA), heteroresistant VISA (hVISA), and daptomycin-nonsusceptible S. aureus (DNSSA) isolates. Ceftaroline may represent a bactericidal treatment option for infections caused by these pathogens.

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