scholarly journals Tbx6 is a determinant of cardiac and neural cell fate decisions in multipotent P19CL6 cells

2012 ◽  
Vol 84 (2) ◽  
pp. 176-184 ◽  
Author(s):  
Svetlana Gavrilov ◽  
Thomas G. Nührenberg ◽  
Anthony W. Ashton ◽  
Chang-Fu Peng ◽  
Jennifer C. Moore ◽  
...  
Keyword(s):  
Cell Fate ◽  
Neural Cell ◽  
Cell Fate Decisions ◽  
P19cl6 Cells ◽  
Neural Cell Fate

scholarly journals Genetic approach to track neural cell fate decisions using human embryonic stem cells

2014 ◽  
Vol 5 (1) ◽  
pp. 69-79 ◽  
Author(s):  
Xuemei Fu ◽  
Zhili Rong ◽  
Shengyun Zhu ◽  
Xiaocheng Wang ◽  
Yang Xu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Cell Fate ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Neural Cell ◽  
Genetic Approach ◽  
Cell Fate Decisions ◽  
Neural Cell Fate

scholarly journals Essential Role for the d-Asb11 cul5 Box Domain for Proper Notch Signaling and Neural Cell Fate Decisions In Vivo

PLoS ONE ◽  
2010 ◽  
Vol 5 (11) ◽  
pp. e14023 ◽  
Author(s):  
Maria A. Sartori da Silva ◽  
Jin-Ming Tee ◽  
Judith Paridaen ◽  
Anke Brouwers ◽  
Vincent Runtuwene ◽  
...  
Keyword(s):  
Notch Signaling ◽  
Cell Fate ◽  
Essential Role ◽  
Neural Cell ◽  
Cell Fate Decisions ◽  
Neural Cell Fate

scholarly journals Chromatin-mediated translational control is essential for neural cell fate specification

2018 ◽  
Vol 1 (4) ◽  
pp. e201700016 ◽  
Author(s):  
Dong-Woo Hwang ◽  
Anbalagan Jaganathan ◽  
Padmina Shrestha ◽  
Ying Jin ◽  
Nour El-Amine ◽  
...  
Keyword(s):  
Cell Fate ◽  
Translational Control ◽  
Ribosome Biogenesis ◽  
Cell Activation ◽  
Neural Cell ◽  
Specific Gene ◽  
Cell Fate Specification ◽  
Cell Fate Decisions ◽  
Fate Specification ◽  
Neural Cell Fate

Neural cell fate specification is a multistep process in which stem cells undergo sequential changes in states, giving rise to particular lineages such as neurons and astrocytes. This process is accompanied by dynamic changes of chromatin and in transcription, thereby orchestrating lineage-specific gene expression programs. A pressing question is how these events are interconnected to sculpt cell fate. We show that altered chromatin due to loss of the chromatin remodeler Chd5 causes neural stem cell activation to occur ahead of time. This premature activation is accompanied by transcriptional derepression of ribosomal subunits, enhanced ribosome biogenesis, and increased translation. These untimely events deregulate cell fate decisions, culminating in the generation of excessive numbers of astrocytes at the expense of neurons. By monitoring the proneural factor Mash1, we further show that translational control is crucial for appropriate execution of cell fate specification, thereby providing new insight into the interplay between transcription and translation at the initial stages of neurogenesis.

scholarly journals Prospero and Pax2 combinatorially control neural cell fate decisions by modulating Ras- and Notch-dependent signaling

2011 ◽  
Vol 6 (1) ◽  
pp. 20 ◽  
Author(s):  
Mark Charlton-Perkins ◽  
S Leigh Whitaker ◽  
Yueyang Fei ◽  
Baotong Xie ◽  
David Li-Kroeger ◽  
...  
Keyword(s):  
Cell Fate ◽  
Neural Cell ◽  
Cell Fate Decisions ◽  
Neural Cell Fate

scholarly journals MicroRNA let-7d regulates the TLX/microRNA-9 cascade to control neural cell fate and neurogenesis

2013 ◽  
Vol 3 (1) ◽  
Author(s):  
Chunnian Zhao ◽  
GuoQiang Sun ◽  
Peng Ye ◽  
Shengxiu Li ◽  
Yanhong Shi
Keyword(s):  
Cell Fate ◽  
Neural Cell ◽  
Neural Cell Fate

scholarly journals Differential requirement for Gli2 and Gli3 in ventral neural cell fate specification

2003 ◽  
Vol 259 (1) ◽  
pp. 150-161 ◽  
Author(s):  
Jun Motoyama ◽  
Ljiljana Milenkovic ◽  
Mizuho Iwama ◽  
Yayoi Shikata ◽  
Matthew P. Scott ◽  
...  
Keyword(s):  
Cell Fate ◽  
Neural Cell ◽  
Cell Fate Specification ◽  
Fate Specification ◽  
Neural Cell Fate

Olig genes and the genetic logic of CNS neural cell fate determination

2002 ◽  
Vol 2 (1-2) ◽  
pp. 17-28 ◽  
Author(s):  
David J Anderson ◽  
Gloria Choi ◽  
Qiao Zhou
Keyword(s):  
Cell Fate ◽  
Neural Cell ◽  
Cell Fate Determination ◽  
Fate Determination ◽  
Neural Cell Fate

scholarly journals Genomic DISC1 Disruption in hiPSCs Alters Wnt Signaling and Neural Cell Fate

Cell Reports ◽  
2015 ◽  
Vol 12 (9) ◽  
pp. 1414-1429 ◽  
Author(s):  
Priya Srikanth ◽  
Karam Han ◽  
Dana G. Callahan ◽  
Eugenia Makovkina ◽  
Christina R. Muratore ◽  
...  
Keyword(s):  
Wnt Signaling ◽  
Cell Fate ◽  
Neural Cell ◽  
Neural Cell Fate

scholarly journals Epigenetic setting and reprogramming for neural cell fate determination and differentiation

2014 ◽  
Vol 369 (1652) ◽  
pp. 20130511 ◽  
Author(s):  
Takuya Imamura ◽  
Masahiro Uesaka ◽  
Kinichi Nakashima
Keyword(s):  
Cell Fate ◽  
Gene Promoter ◽  
Neural Cell ◽  
Mammalian Brain ◽  
Cell Cycle Regulators ◽  
Promoter Regions ◽  
Cell Fates ◽  
Intergenic Regions ◽  
Variable Combination ◽  
Neural Cell Fate

In the mammalian brain, epigenetic mechanisms are clearly involved in the regulation of self-renewal of neural stem cells and the derivation of their descendants, i.e. neurons, astrocytes and oligodendrocytes, according to the developmental timing and the microenvironment, the ‘niche’. Interestingly, local epigenetic changes occur, concomitantly with genome-wide level changes, at a set of gene promoter regions for either down- or upregulation of the gene. In addition, intergenic regions also sensitize the availability of epigenetic modifiers, which affects gene expression through a relatively long-range chromatinic interaction with the transcription regulatory machineries including non-coding RNA (ncRNA) such as promoter-associated ncRNA and enhancer ncRNA. We show that such an epigenetic landscape in a neural cell is statically but flexibly formed together with a variable combination of generally and locally acting nuclear molecules including master transcription factors and cell-cycle regulators. We also discuss the possibility that revealing the epigenetic regulation by the local DNA–RNA–protein assemblies would promote methodological innovations, e.g. neural cell reprogramming, engineering and transplantation, to manipulate neuronal and glial cell fates for the purpose of medical use of these cells.

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