scholarly journals Genomic DISC1 Disruption in hiPSCs Alters Wnt Signaling and Neural Cell Fate

Cell Reports ◽  
2015 ◽  
Vol 12 (9) ◽  
pp. 1414-1429 ◽  
Author(s):  
Priya Srikanth ◽  
Karam Han ◽  
Dana G. Callahan ◽  
Eugenia Makovkina ◽  
Christina R. Muratore ◽  
...  
Keyword(s):  
Wnt Signaling ◽  
Cell Fate ◽  
Neural Cell ◽  
Neural Cell Fate

scholarly journals MicroRNA let-7d regulates the TLX/microRNA-9 cascade to control neural cell fate and neurogenesis

2013 ◽  
Vol 3 (1) ◽  
Author(s):  
Chunnian Zhao ◽  
GuoQiang Sun ◽  
Peng Ye ◽  
Shengxiu Li ◽  
Yanhong Shi
Keyword(s):  
Cell Fate ◽  
Neural Cell ◽  
Neural Cell Fate

scholarly journals Tbx6 is a determinant of cardiac and neural cell fate decisions in multipotent P19CL6 cells

2012 ◽  
Vol 84 (2) ◽  
pp. 176-184 ◽  
Author(s):  
Svetlana Gavrilov ◽  
Thomas G. Nührenberg ◽  
Anthony W. Ashton ◽  
Chang-Fu Peng ◽  
Jennifer C. Moore ◽  
...  
Keyword(s):  
Cell Fate ◽  
Neural Cell ◽  
Cell Fate Decisions ◽  
P19cl6 Cells ◽  
Neural Cell Fate

scholarly journals Differential requirement for Gli2 and Gli3 in ventral neural cell fate specification

2003 ◽  
Vol 259 (1) ◽  
pp. 150-161 ◽  
Author(s):  
Jun Motoyama ◽  
Ljiljana Milenkovic ◽  
Mizuho Iwama ◽  
Yayoi Shikata ◽  
Matthew P. Scott ◽  
...  
Keyword(s):  
Cell Fate ◽  
Neural Cell ◽  
Cell Fate Specification ◽  
Fate Specification ◽  
Neural Cell Fate

Olig genes and the genetic logic of CNS neural cell fate determination

2002 ◽  
Vol 2 (1-2) ◽  
pp. 17-28 ◽  
Author(s):  
David J Anderson ◽  
Gloria Choi ◽  
Qiao Zhou
Keyword(s):  
Cell Fate ◽  
Neural Cell ◽  
Cell Fate Determination ◽  
Fate Determination ◽  
Neural Cell Fate

scholarly journals Epigenetic setting and reprogramming for neural cell fate determination and differentiation

2014 ◽  
Vol 369 (1652) ◽  
pp. 20130511 ◽  
Author(s):  
Takuya Imamura ◽  
Masahiro Uesaka ◽  
Kinichi Nakashima
Keyword(s):  
Cell Fate ◽  
Gene Promoter ◽  
Neural Cell ◽  
Mammalian Brain ◽  
Cell Cycle Regulators ◽  
Promoter Regions ◽  
Cell Fates ◽  
Intergenic Regions ◽  
Variable Combination ◽  
Neural Cell Fate

In the mammalian brain, epigenetic mechanisms are clearly involved in the regulation of self-renewal of neural stem cells and the derivation of their descendants, i.e. neurons, astrocytes and oligodendrocytes, according to the developmental timing and the microenvironment, the ‘niche’. Interestingly, local epigenetic changes occur, concomitantly with genome-wide level changes, at a set of gene promoter regions for either down- or upregulation of the gene. In addition, intergenic regions also sensitize the availability of epigenetic modifiers, which affects gene expression through a relatively long-range chromatinic interaction with the transcription regulatory machineries including non-coding RNA (ncRNA) such as promoter-associated ncRNA and enhancer ncRNA. We show that such an epigenetic landscape in a neural cell is statically but flexibly formed together with a variable combination of generally and locally acting nuclear molecules including master transcription factors and cell-cycle regulators. We also discuss the possibility that revealing the epigenetic regulation by the local DNA–RNA–protein assemblies would promote methodological innovations, e.g. neural cell reprogramming, engineering and transplantation, to manipulate neuronal and glial cell fates for the purpose of medical use of these cells.

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