Temporal response of liver signal transduction elements during in vivo endotoxin challenge in cattle: Effects of growth hormone treatment

2007 ◽  
Vol 32 (2) ◽  
pp. 79-92 ◽  
Author(s):  
Cong-Jun Li ◽  
Stanislaw Kahl ◽  
Donald Carbaugh ◽  
Theodore H. Elsasser
Keyword(s):  
Signal Transduction ◽  
Growth Hormone ◽  
Growth Hormone Treatment ◽  
Hormone Treatment ◽  
Temporal Response ◽  
Endotoxin Challenge

Effect of chronic growth hormone treatment on insulin signal transduction in rat tissues

1997 ◽  
Vol 130 (1-2) ◽  
pp. 33-42 ◽  
Author(s):  
Ana C.P Thirone ◽  
Carla R.O Carvalho ◽  
Sigisfredo L Brenelli ◽  
Lı́cio A Velloso ◽  
Mario J.A. Saad
Keyword(s):  
Signal Transduction ◽  
Growth Hormone ◽  
Growth Hormone Treatment ◽  
Hormone Treatment ◽  
Rat Tissues ◽  
Insulin Signal Transduction ◽  
Insulin Signal

scholarly journals In vivo growth hormone treatment rapidly stimulates the tyrosine phosphorylation and activation of Stat3.

1995 ◽  
Vol 9 (2) ◽  
pp. 171-177 ◽  
Author(s):  
A M Gronowski ◽  
Z Zhong ◽  
Z Wen ◽  
M J Thomas ◽  
J E Darnell ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Tyrosine Phosphorylation ◽  
Growth Hormone Treatment ◽  
Hormone Treatment ◽  
In Vivo Growth

Protein turnover in rat skeletal muscle: effects of hypophysectomy and growth hormone.

1978 ◽  
Vol 234 (1) ◽  
pp. E38 ◽  
Author(s):  
K E Flaim ◽  
J B Li ◽  
L S Jefferson
Keyword(s):  
Skeletal Muscle ◽  
Growth Hormone ◽  
Protein Synthesis ◽  
Protein Turnover ◽  
Gastrocnemius Muscle ◽  
Growth Hormone Treatment ◽  
Hormone Replacement ◽  
Hormone Treatment ◽  
Rat Skeletal Muscle

The role of growth hormone in regulating protein turnover was examined in a perfused preparation of rat skeletal muscle. The perfused muscle maintained in vivo levels of ATP and creatine phosphate and exhibited constant rates of oxygen consumption and protein synthesis. Hypophysectomy reduced the rate of protein synthesis, the concentration of RNA, and the efficiency of protein synthesis in gastrocnemius muscle to 30, 46, and 66 percent of normal, respectively. In vivo treatment of hypophysectomized (hypox) rats with bovine growth hormone (250 microgram/day for 5 days) resulted in small increases in protein synthesis and RNA, whereas synthesis/RNA was returned to near normal. Elevation of ribosomal subunits in psoas muscle indicated an inhibition of peptide-chain initiation in hypox rats that was reversed by in vivo growth hormone treatment. Thus, hypox rats exhibited both a decreased capacity and a decreased efficiency of protein synthesis. Growth hormone replacement primarily increased efficiency of protein synthesis. The rate of protein degradation and the activity of cathepsin D in gastrocnemius muscle were decreased by hypophysectomy. Growth hormone treatment had no significant effect on degradation.

scholarly journals In vivo Investigations of the Effect of Short- and Long-Term Recombinant Growth Hormone Treatment on DNA-Methylation in Humans

PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0120463 ◽  
Author(s):  
Julia Kolarova ◽  
Ole Ammerpohl ◽  
Jana Gutwein ◽  
Maik Welzel ◽  
Inka Baus ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Growth Hormone ◽  
Growth Hormone Treatment ◽  
Hormone Treatment ◽  
Recombinant Growth Hormone ◽  
Short And Long Term

Effect of growth hormone on carbohydrate metabolism in normal and hypophysectomized dogs; studies with C14 glucose

1958 ◽  
Vol 196 (1) ◽  
pp. 121-124 ◽  
Author(s):  
N. Altszuler ◽  
R. Steele ◽  
J. S. Wall ◽  
A. Dunn ◽  
R. C. de Bodo
Keyword(s):  
Growth Hormone ◽  
Glucose Utilization ◽  
Growth Hormone Treatment ◽  
Glucose Production ◽  
Hormone Treatment ◽  
Inhibitory Effect ◽  
The Body ◽  
Constant Infusion ◽  
Endogenous Insulin

Using trace amounts of C14 glucose, introduced intravenously by a priming injection along with a continuous constant infusion, the effect of a growth hormone regimen on the size of body glucose pool and on the rate of glucose utilization as well as production was studied in unanesthetized normal and hypophysectomized dogs. In both types of animals the growth hormone regimen increased the size of the body glucose pool. More significantly the growth hormone regimen increased the rate of glucose utilization as well as the rate of glucose production. It is proposed that the inhibitory effect of injected growth hormone on glucose uptake observed in isolated diaphragm is overcome in vivo by an increased endogenous insulin secretion evoked by the extra glucose produced as a result of the growth hormone treatment.

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