Effect of growth hormone on carbohydrate metabolism in normal and hypophysectomized dogs; studies with C14 glucose

Using trace amounts of C14 glucose, introduced intravenously by a priming injection along with a continuous constant infusion, the effect of a growth hormone regimen on the size of body glucose pool and on the rate of glucose utilization as well as production was studied in unanesthetized normal and hypophysectomized dogs. In both types of animals the growth hormone regimen increased the size of the body glucose pool. More significantly the growth hormone regimen increased the rate of glucose utilization as well as the rate of glucose production. It is proposed that the inhibitory effect of injected growth hormone on glucose uptake observed in isolated diaphragm is overcome in vivo by an increased endogenous insulin secretion evoked by the extra glucose produced as a result of the growth hormone treatment.

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How sociophenomenology of the body problematises the ‘problem-oriented approach’ to growth hormone treatment

Medical Humanities ◽

10.1136/medhum-2018-011548 ◽

2018 ◽

Vol 46 (1) ◽

pp. 2-11

Author(s):

Maria Cristina Murano ◽

Jenny Slatman ◽

Kristin Zeiler

Keyword(s):

Growth Hormone ◽

Short Stature ◽

Lived Experience ◽

Lived Experiences ◽

Growth Hormone Treatment ◽

Hormone Treatment ◽

The Body ◽

Psychological Assessments ◽

Objective Space ◽

Oriented Approach

This article examines how people who are shorter than average make sense of their lived experience of embodiment. It offers a sociophenomenological analysis of 10 semistructured interviews conducted in the Netherlands, focusing on if, how, and why height matters to them. It draws theoretically on phenomenological discussions of lived and objective space, intercorporeality and norms about bodies. The analysis shows that height as a lived phenomenon (1) is active engagement in space, (2) coshapes habituated ways of behaving and (3) is shaped by gendered norms and beliefs about height. Based on this analysis, the article challenges what we label as the ‘problem-oriented approach’ to discussions about growth hormone treatment for children with idiopathic short stature. In this approach, possible psychosocial disadvantages or problems of short stature and quantifiable height become central to the ethical evaluation of growth hormone treatment at the expense of first-hand lived experiences of short stature and height as a lived phenomenon. Based on our sociophenomenological analysis, this paper argues that the rationale for giving growth hormone treatment should combine medical and psychological assessments with investigations of lived experiences of the child. Such an approach would allow considerations not only of possible risks or disadvantages of short stature but also of the actual ways in which the child makes sense of her or his height.

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In vivo growth hormone treatment rapidly stimulates the tyrosine phosphorylation and activation of Stat3.

Molecular Endocrinology ◽

10.1210/mend.9.2.7776967 ◽

1995 ◽

Vol 9 (2) ◽

pp. 171-177 ◽

Cited By ~ 3

Author(s):

A M Gronowski ◽

Z Zhong ◽

Z Wen ◽

M J Thomas ◽

J E Darnell ◽

...

Keyword(s):

Growth Hormone ◽

Tyrosine Phosphorylation ◽

Growth Hormone Treatment ◽

Hormone Treatment ◽

In Vivo Growth

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Protein turnover in rat skeletal muscle: effects of hypophysectomy and growth hormone.

AJP Endocrinology and Metabolism ◽

10.1152/ajpendo.1978.234.1.e38 ◽

1978 ◽

Vol 234 (1) ◽

pp. E38 ◽

Cited By ~ 1

Author(s):

K E Flaim ◽

J B Li ◽

L S Jefferson

Keyword(s):

Skeletal Muscle ◽

Growth Hormone ◽

Protein Synthesis ◽

Protein Turnover ◽

Gastrocnemius Muscle ◽

Growth Hormone Treatment ◽

Hormone Replacement ◽

Hormone Treatment ◽

Rat Skeletal Muscle

The role of growth hormone in regulating protein turnover was examined in a perfused preparation of rat skeletal muscle. The perfused muscle maintained in vivo levels of ATP and creatine phosphate and exhibited constant rates of oxygen consumption and protein synthesis. Hypophysectomy reduced the rate of protein synthesis, the concentration of RNA, and the efficiency of protein synthesis in gastrocnemius muscle to 30, 46, and 66 percent of normal, respectively. In vivo treatment of hypophysectomized (hypox) rats with bovine growth hormone (250 microgram/day for 5 days) resulted in small increases in protein synthesis and RNA, whereas synthesis/RNA was returned to near normal. Elevation of ribosomal subunits in psoas muscle indicated an inhibition of peptide-chain initiation in hypox rats that was reversed by in vivo growth hormone treatment. Thus, hypox rats exhibited both a decreased capacity and a decreased efficiency of protein synthesis. Growth hormone replacement primarily increased efficiency of protein synthesis. The rate of protein degradation and the activity of cathepsin D in gastrocnemius muscle were decreased by hypophysectomy. Growth hormone treatment had no significant effect on degradation.

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Assessment of anterior-posterior spinal curvatures in children suffering from hypopituitarism

BMC Endocrine Disorders ◽

10.1186/s12902-019-0462-4 ◽

2019 ◽

Vol 19 (1) ◽

Author(s):

Magdalena Kobylińska ◽

Roksana Malak ◽

Katarzyna Majewska ◽

Andrzej Kędzia ◽

Włodzimierz Samborski

Keyword(s):

Growth Hormone ◽

Hormone Therapy ◽

Growth Hormone Treatment ◽

Growth Hormone Therapy ◽

Alpha Angle ◽

Hormone Treatment ◽

The Body ◽

Body Posture ◽

Spinal Curvatures ◽

Anterior Posterior

Abstract Background Body posture may be disordered by vestibular dysfunction, neurological disorders, problems with the distribution of muscle tone, brain injuries, and other dysfunctions. Growth hormone deficiency (GHD) can lead to many disorders, particularly of the musculoskeletal system. During treatment with recombinant human growth hormone (rhGH), an increase in muscle mass and an improvement in bone structure can be observed in children suffering from hypopituitarism from GHD. Methods The study involved 33 children suffering from hypopituitarism with GHD (9 girls and 24 boys), aged 10–14 years old. Measurements of the magnitude of their anterior–posterior spinal curvatures were made using an inclinometer. The children were examined at the medianus of the sacrum bone, the Th12–L1 intervertebral area, and the C7–Th1 intervertebral area. In order to characterize the anterior–posterior curvature of the spine, the results were compared with the general norms reported by Saunders. Statistical calculations were carried out using the statistical package Statistica 10 PL. Results Lumbar lordosis angles were higher in the patients currently receiving growth hormone (GH) treatment than in those who had yet to receive it. There is a statistically significant positive correlation between the length of growth hormone treatment and the alpha angle. There are also statistically significant correlations between age at the beginning of growth hormone therapy and the angle of lordosis. Statistically significant correlations were also seen between age at the beginning of growth hormone therapy and the alpha angle. Conclusions Although there may be changes in posture at the beginning of rhGH treatment, the sooner growth hormone therapy begins, the better the body posture. The longer the growth hormone treatment, the better the posture, as expressed by the alpha angle in the sagittal plane.

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