Nucleated red blood cells as marker for an increased risk of unfavorable outcome and mortality in very low birth weight infants

2015 ◽  
Vol 91 (10) ◽  
pp. 559-563 ◽  
Author(s):  
Malte Cremer ◽  
Stephanie Roll ◽  
Charlotte Gräf ◽  
Andreas Weimann ◽  
Christoph Bührer ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Very Low Birth Weight ◽  
Unfavorable Outcome ◽  
Low Birth Weight Infants ◽  
Nucleated Red Blood Cells ◽  
Increased Risk

Retrolental Fibroplasia and Blood Transfusion in Very Low-Birth-Weight Infants

PEDIATRICS ◽  
1981 ◽  
Vol 68 (6) ◽  
pp. 770-774 ◽  
Author(s):  
Linda M. Sacks ◽  
David B. Schaffer ◽  
Endla K. Anday ◽  
George J. Peckham ◽  
Maria Delivoria-Papadopoulos
Keyword(s):  
Birth Weight ◽  
Blood Transfusion ◽  
Low Birth Weight ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Very Low Birth Weight ◽  
Statistical Significance ◽  
Low Birth Weight Infants ◽  
Retrolental Fibroplasia ◽  
Packed Red Blood Cells

The relative contribution of transfusions of adult blood to the development of retrolental fibroplasia (RLF) in very low-birth-weight infants was examined. Five years of experience with the expanded use of replacement and exchange transfusions in 90 infants with birth weight ≤1,250 gm was reviewed. Twenty percent of the infants developed cicatricial RLF. Exchange transfusion was not related to development of cicatricial RLF. The incidence of RLF in infants receiving ≥130 ml of packed red blood cells per kilogram of birth weight as replacement blood transfusion (RBT) was significantly higher (42.9%) than that in infants receiving 61 to 131 ml of packed red blood cells per kilogram (15.4%) and infants receiving ≤60 ml of packed red blood cells per kilogram (0%), P < .001. The need for RBT, however, was strongly correlated (r = .85, P < .001) with increasing duration of O2 therapy. When O2 therapy was controlled for, the association between RBT and RLF did not achieve statistical significance (P = .07). The association between RBT and RLF remained significant when adjusted for duration of therapy in fractional inspired oxygen (FIO2) >0.4. Further detailed studies of large numbers of susceptible infants are warranted to assess the magnitude of the contribution of transfusions of adult blood to development of RLF.

Iron Absorption and Incorporation into Red Blood Cells by Very Low Birth Weight Infants

1992 ◽  
Vol 15 (3) ◽  
pp. 270-278 ◽  
Author(s):  
Richard A. Ehrenkranz ◽  
Patricia A. Gettner ◽  
Catherine M. Nelli ◽  
Elaine A. Sherwonit ◽  
Joanne E. Williams ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Very Low Birth Weight ◽  
Iron Absorption ◽  
Low Birth Weight Infants

scholarly journals Application of near-infrared spectroscopy in extremely and very low birth weight infants for red blood cells transfusion

2020 ◽  
Vol 19 (3) ◽  
pp. 18-25
Author(s):  
D. R. Sharafutdinova ◽  
E. N. Balashova ◽  
O. V. Ionov ◽  
A. R. Kirtbaya ◽  
J. M. Golubtsova ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Red Blood Cells ◽  
Near Infrared Spectroscopy ◽  
Blood Cells ◽  
Near Infrared ◽  
Very Low Birth Weight ◽  
Low Birth Weight Infants ◽  
Non Invasive

Near-infrared spectroscopy (NIRS), or cerebral oximetry, is a non-invasive method for assessing the oxidative status (saturation of hemoglobin with oxygen) mainly in the blood of cerebral venous vessels, which is increasingly used in clinical practice, in particular in neonatology. This method allows us to evaluate not only tissue perfusion, but also to determine the differences between the indicators of cerebral and peripheral oxygenation. Few studies have described improvements in tissue oxygenation indicators determined by NIRS after red blood cells transfusion in premature newborns. In our study we registered the oximetry indicators before and after red blood cells transfusion in extremely and very low birth weight infants (n = 55). This clinical study was approved by the Biomedical Research Ethics Committee (Protocol No. 19 dated 17 November 2016) and the Scientific Council of the Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of Ministry of Healthcare of the Russian Federation (Protocol No. 19 dated 29 November 2016). Our study demonstrated a statistically significant increase in CrSO2 , SrSO2 , RrSO2 and SCOR and a decrease in C-FTOE, S-FTOE after a blood transfusion. The study also showed that a decrease in NIRS values (SCOR ≤ 0.76, C-FTOE ≥ 0.29, CrSO2 ≤ 64%, SrSO2 ≤ 54%, and RrSO2 ≤ 56%) can serve as an additional non-invasive measure of anemia and its progression; it helps detect a decrease in cerebral oxygenation at an early, preclinical stage of disease, and can also be used as an additional indicator of the need for red blood cell transfusions. 

Posttransfusion recovery of stored red blood cells in very low birth weight infants using a hemoglobin balance model

Transfusion ◽  
2004 ◽  
Vol 44 (7) ◽  
pp. 1019-1024 ◽  
Author(s):  
Anne Grete Bechensteen ◽  
Sunny Chapel ◽  
Peter Veng-Pedersen ◽  
John A. Widness
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Very Low Birth Weight ◽  
Balance Model ◽  
Low Birth Weight Infants

Increased Risk for Bronchitis after Discharge in Non-vaccinated Very Low Birth Weight Infants

2015 ◽  
Vol 227 (02) ◽  
pp. 80-83
Author(s):  
G. Stichtenoth ◽  
C. Härtel ◽  
J. Spiegler ◽  
M. Dördelmann ◽  
J. Möller ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Very Low Birth Weight ◽  
Low Birth Weight Infants ◽  
Increased Risk

scholarly journals Prevalence of hearing impairment and language and cognition delay in very low birth weight babies and their risk factors

2021 ◽  
Vol 12 (12) ◽  
pp. 62-67
Author(s):  
Saugata Chaudhuri ◽  
Suchandra Mukherjee ◽  
Tanmoy Kumar Bose ◽  
Turna Roy Chowdhury
Keyword(s):  
Risk Factors ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Hearing Impairment ◽  
Very Low Birth Weight ◽  
Cost Effective ◽  
Cognitive Outcome ◽  
Low Birth Weight Infants ◽  
Vlbw Infants ◽  
Increased Risk

Background: Very low birth weight infants are at increased risk of language, cognition delay and also hearing impairment disorder. Identification is essential for early intervention. Aims and Objectives: To estimate the burden of language, cognition delay and hearing impairment at 24 months of corrected gestation and to test the association of examination at 6 months and 12 months with the language and cognitive outcome of very low birth weight (VLBW) infants at 24 months and to identify the perinatal and neonatal risk factors for atypical outcome. Materials and Methods: It is a prospective cohort study. Consecutive 120 VLBW infants were enrolled in a single centre level III neonatal unit of a teaching hospital. Hearing assessment was done before discharge and 3 monthly. Language and cognitive assessment was done by DASII Scale neu at 6 months and BSIDIII Scale at 12 months and 24 months at neurodevelopmental clinic. Language assessment was further done by REELS-3 Subscale at 24 months. All assessment ages were corrected for prematurity. Results: At 24 months 7.8% infants developed Language delay and 4.7% had cognition delay. Four infants developed cerebral palsy at 24 months. Shock in neonatal period had significant association with suboptimal Hearing, Language and Cognitive outcome at 12 months of corrected gestation. Conclusion: Early anticipation and early identification of abnormal hearing, language and cognitive outcome of VLBW infants can be used as simple and cost-effective measures for preventing long-term morbidity at resource limited countries.

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