Distal Tibial Tuberosity Focal Dome Osteotomy Combined With Intra-Articular Condylar Osteotomy (Focal Dome Condylar Osteotomy) for Medial Osteoarthritis of the Knee Joint

Abstract Background The assessment of improvement or maintenance of joint health in healthy subjects is a great challenge. The aim of the study was the evaluation of a joint stress test to assess joint discomfort in subjects with activity-related knee joint discomfort (ArJD). Results Forty-five subjects were recruited to perform the single-leg-step-down (SLSD) test (15 subjects per group). Subjects with ArJD of the knee (age 22–62 years) were compared to healthy subjects (age 24–59 years) with no knee joint discomfort during daily life sporting activity and to subjects with mild-to-moderate osteoarthritis of the knee joint (OA, Kellgren score 2–3, age 42–64 years). The subjects performed the SLSD test with two different protocols: (I) standardization for knee joint discomfort; (II) standardization for load on the knee joint. In addition, range of motion (ROM), reach test, acute pain at rest and after a single-leg squat and knee injury, and osteoarthritis outcome score (KOOS) were assessed. In OA and ArJD subjects, knee joint discomfort could be reproducibly induced in a short time interval of less than 10 min (200 steps). In healthy subjects, no pain was recorded. A clear differentiation between study groups was observed with the SLSD test (maximal step number) as well as KOOS questionnaire, ROM, and reach test. In addition, a moderate to good intra-class correlation was shown for the investigated outcomes. Conclusions These results suggest the SLSD test is a reliable tool for the assessment of knee joint health function in ArJD and OA subjects to study the improvements in their activities. Further, this model can be used as a stress model in intervention studies to study the impact of stress on knee joint health function.

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Predictors of response to intra-articular steroid injections in patients with osteoarthritis of the knee joint

Clinical Rheumatology ◽

10.1007/s10067-016-3365-z ◽

2016 ◽

Vol 35 (10) ◽

pp. 2541-2547 ◽

Cited By ~ 11

Author(s):

Nibah Fatimah ◽

Babur Salim ◽

Ejaz-ul-Haq Raja ◽

Amjad Nasim

Keyword(s):

Knee Joint ◽

Osteoarthritis Of The Knee ◽

Steroid Injections ◽

Predictors Of Response

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Experience of Domed High Tibial Osteotomy in Osteoarthritis of the Knee joint

Orthopedics & Traumatology ◽

10.5035/nishiseisai.31.768 ◽

1983 ◽

Vol 31 (4) ◽

pp. 768-773

Author(s):

M. Oryoji ◽

Y. Takeda ◽

M. Kijima ◽

K. Yoshinaga ◽

K. Tomari

Keyword(s):

Knee Joint ◽

High Tibial Osteotomy ◽

Osteoarthritis Of The Knee ◽

Tibial Osteotomy

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Hope, Hype, Hurdles & Future Perspective for PRP, PRP versus Hyaluronic Acid Injection in Osteoarthritis of Knee: A Review Article.

Biologic Orthopedics Journal ◽

10.22374/boj.v2i1.6 ◽

2020 ◽

Vol 2 (1) ◽

pp. e1-e12

Author(s):

Ashok Kumar ◽

Anikait Ghosh Kadamb ◽

Krish Ghosh Kadamb

Keyword(s):

Hyaluronic Acid ◽

Knee Joint ◽

Platelet Rich Plasma ◽

Future Perspective ◽

Osteoarthritis Of The Knee ◽

Stiff Knee ◽

Injection Interval ◽

One Year

BackgroundComparative studies of platelet-rich plasma (PRP) and hyaluronic acid show variable results. PurposeA review was conducted to understand the current role of PRP and its efficacy versus hyaluronic acid in osteoarthritis (OA) of the knee joint. MethodsOut of 170 identified studies, 14 studies involving 1575 patients with 637 males and 938 females were selected based on PRISMA flow chart guidelines and were analyzed for the study. ResultsA standard PRP regimen consisting of 2–3 intra-articular injections (IA) of 4–6 mL of leucocyte poor PRP at 1–2 weekly intervals provides a better result than HA during the first 3–6 months, and which may continue up to one year. PRP and HA may have synergistic effect; pain and swelling are the two most com-mon complications with PRP, the incidence is more with leucocyte rich PRP (LP-PRP) and intra-osseous PRP treatment.ConclusionPRP provides hope and is more effective than hyaluronic acid in pain relief and improving the quality of life in mild to moderate osteoarthritis of the knee joint. However, hype, that is effective in all, irrespective of grades of OA, mal-aligned or stiff knee, ligamentous laxity, and can avoid joint replacement is a big hindrance in establishing it as a preferred treatment in OA knee. The author follows the above-mentioned PRP regimen; and recommends to combine leucocyte poor PRP with HA for IA injections & with LP-PRP injections along with the two most common painful points (medial collateral ligament, pesanisernius) in a highly painful OA knee. PRP may not address extra-articular causes of knee pain (mal-alignment, muscle wasting, tendinosis), should be corrected for optimum outcome. Contact sports, running, exercises putting pressure on knee and NSAID should be avoided during PRP treatment. Also, more randomized controlled trials are required to further standardize the PRP preparation, administration, injection interval & proper documentation of efficacy and complications in the regenerative registry.

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MORPHOLOGICAL CHANGES IN THE TISSUES OF THE RABBIT KNEE JOINT DUE TO EXPERIMENTAL OSTEOARTHRITIS AFTER THE USE OF MESENCHYMAL STEM CELLS

Folia Pomeranae Universitatis Technologiae Stetinensis Agricultura Alimentaria Piscaria et Zootechnica ◽

10.21005/aapz2021.58.2.02 ◽

2021 ◽

Vol 359 (58) ◽

pp. 13-24

Author(s):

Nikolai MALYUK ◽

◽

Yuliia DEMIANTSEVA ◽

Yuriy KHARKEVYCH ◽

Roman BOKOTKO ◽

...

Keyword(s):

Stem Cells ◽

Mesenchymal Stem Cells ◽

Articular Cartilage ◽

Knee Joint ◽

Traditional Method ◽

Control Group ◽

Osteoarthritis Of The Knee ◽

Allogeneic Bone ◽

Experimental Osteoarthritis ◽

Experimental Group

The purpose of the study was to investigate the regenerative processes in the knee joint of rabbits with experimental osteoarthritis after using of allogeneic bone marrow stem cells and a traditional treatment with the non-steroidal anti-inflammatory drug Meloxicam. For the experiment were used 27 male California rabbits (males). Three groups of animals were formed: a control group; the first experimental group treated by the traditional method; the second experimental group treated with allogeneic mesenchymal stem cells (MSC). Animals in the three groups were subjected to osteoarthritis of the knee joint by double injection of 3.44% retinol acetate into the joint cavity at a dose of 1 ml at intervals of 7 days. Tissue from the affected site was sampled for histological examination at 7, 14 and 28 days. The histological sections were stained with haematoxylin-eosin and examined under a microscope. It has been established that intra-articular administration of 3.5 × 106 cells of allogeneic MSCs in experimental osteoarthritis contributes to the restoration of the superficial layer of cartilage, as evidenced by the formation of columns of chondrocytes in the middle layer of articular cartilage and the appearance of isogenic groups of cartilage cells with basophilic cytoplasm in the matrix, uniform articular surface. The use of the traditional method of treating rabbits using the drug Meloxicam is accompanied by incomplete chondrogenesis: part of the chondrocytes is localized in typical chambers, in some cases chondrocyte chambers did not differentiate; articular cartilage had unequal thickness, cell placement was uneven.

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Research Progress on Acupuncture Treatment of Knee Osteoarthritis

Asian Journal of Complementary and Alternative Medicine ◽

10.53043/2347-3894.acam90019 ◽

2021 ◽

Vol 9 (4) ◽

pp. 106-110

Author(s):

Zhang Yueyu ◽

Song Aiqun ◽

Peng Ying

Keyword(s):

Acupuncture Therapy ◽

Knee Joint ◽

Knee Osteoarthritis ◽

Joint Pain ◽

Acupuncture Treatment ◽

Treatment Plan ◽

Joint Inflammation ◽

Research Progress ◽

Osteoarthritis Of The Knee ◽

Joint Function

Osteoarthritis of the knee is a common clinical degenerative disease, which occurs in middle-aged and elderly people. Acupuncture therapy has a significant effect in the treatment of knee osteoarthritis, and is gradually accepted by more and more patients. Observing the treatment of knee osteoarthritis by different acupuncture and moxibustion therapies, we can find that acupuncture treatment of knee osteoarthritis has the advantages of relieving knee joint pain, improving knee joint function, absorbing knee joint inflammation, and promoting the recovery of damaged soft tissue. The treatment of osteoarthritis provides a more effective treatment plan.

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