scholarly journals Diagnostic value of N-terminal pro-brain natriuretic peptide levels in pediatric patients with ventricular septal defect

2012 ◽  
Vol 64 (4) ◽  
pp. 241-246 ◽  
Author(s):  
Sahar Elsharawy ◽  
Bashir Hassan ◽  
Saed Morsy ◽  
Naglaa Khalifa
Keyword(s):  
Ventricular Septal Defect ◽  
Brain Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Pediatric Patients ◽  
Septal Defect ◽  
Diagnostic Value

Brain Natriuretic Peptide Levels Before and After Ventricular Septal Defect Repair

2007 ◽  
Vol 84 (6) ◽  
pp. 2066-2069 ◽  
Author(s):  
Richard D. Mainwaring ◽  
Carol Parise ◽  
Stanley B. Wright ◽  
Andrew L. Juris ◽  
Robert A. Achtel ◽  
...  
Keyword(s):  
Ventricular Septal Defect ◽  
Brain Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Septal Defect ◽  
Before And After ◽  
Defect Repair

Does N-terminal pro-brain natriuretic peptide correlate with measured shunt fraction in children with septal defects?

2015 ◽  
Vol 26 (3) ◽  
pp. 469-476
Author(s):  
Abdullah Ozyurt ◽  
Ali Baykan ◽  
Mustafa Argun ◽  
Ozge Pamukcu ◽  
Kazim Uzum ◽  
...  
Keyword(s):  
Ventricular Septal Defect ◽  
Brain Natriuretic Peptide ◽  
Atrial Septal Defect ◽  
Natriuretic Peptide ◽  
Significant Positive Correlation ◽  
Septal Defect ◽  
Ventricular Septal Defects ◽  
Positive Correlation ◽  
Haemodynamic Parameters ◽  
Septal Defects

AbstractBackgroundThe aim of this study was to investigate the potential role of N-terminal pro-brain natriuretic peptide in the assessment of shunt severity and invasive haemodynamic parameters in children with atrial septal defects and ventricular septal defects.MethodsThis is a prospective, controlled (n:62), observational study. Correlation analysis was performed between N-terminal pro-brain natriuretic peptide levels and various invasive haemodynamic measurements in 127 children (ventricular septal defect: 64; atrial septal defect: 63). A ratio of pulmonary to systemic blood flow (Qp/Qs⩾1.5) was considered to indicate a significant shunt.ResultsStatistically significant relationship was found between the mean N-terminal pro-brain natriuretic peptide values of the patients, with Qp/Qs⩾1.5 in both defect types and control group. For ventricular septal defect, N-terminal pro-brain natriuretic peptide level⩾113.5 pg/ml was associated with high specificity and sensitivity for determining the significant shunt. In addition, the cut-off point for determining the significant shunt for atrial septal defect was 57.9 pg/ml. Significant positive correlation was found between all invasive haemodynamic parameters and N-terminal pro-brain natriuretic peptide levels in patients with ventricular septal defects. Whereas significant positive correlation was found only between mean pulmonary artery pressure, right ventricular end-diastolic pressure, and systemic pressure to pulmonary pressure ratio and N-terminal pro-brain natriuretic peptide levels in patients with atrial septal defects.ConclusionOur study demonstrated that the N-terminal pro-brain natriuretic peptide measurements could be used as a supporting parameter in determining significance of the shunt.

The usefulness of brain natriuretic peptide in simple congenital heart disease – a systematic review

2012 ◽  
Vol 23 (3) ◽  
pp. 315-324 ◽  
Author(s):  
Jannet A. Eindhoven ◽  
Annemien E. van den Bosch ◽  
Eric Boersma ◽  
Jolien W. Roos-Hesselink
Keyword(s):  
Systematic Review ◽  
Congenital Heart Disease ◽  
Heart Disease ◽  
Ventricular Septal Defect ◽  
Brain Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Prognostic Value ◽  
Congenital Heart ◽  
Septal Defect

AbstractBrain natriuretic peptide and N-terminal pro-brain natriuretic peptide are two well-established markers for cardiac failure in acquired heart disease. Nevertheless, the clinical utility of these markers in patients with congenital heart disease remains unclear. Therefore, the aim of this study was to evaluate the diagnostic and prognostic value of these markers in patients with congenital heart disease. A PubMed and EMBASE literature search was executed with focus on the most common simple congenital heart defects, atrial septal defect and ventricular septal defect. Data on brain natriuretic peptide measurement, cardiac function parameters, and follow-up were collected. In patients with atrial or ventricular septal defect, brain natriuretic peptide levels were mildly increased when compared with healthy age-matched controls. Shunt severity and pulmonary artery pressure correlated strongly with natriuretic peptide levels. A clear association between brain natriuretic peptide and functional class was demonstrated. After closure of the defect, a rise in brain natriuretic peptide levels in the first hours to days was observed. After longer follow-up, natriuretic peptide levels decreased and became comparable to pre-procedural values. In conclusion, this systematic review shows that brain natriuretic peptide levels are mildly increased in patients with unrepaired and repaired atrial or ventricular septal defect. Brain natriuretic peptide measurement might be a useful additional tool in the diagnostic work-up of patients with atrial or ventricular septal defect. Further investigation in a larger, prospective study with long-term follow-up is warranted to elucidate the true prognostic value of natriuretic peptides in patients with simple congenital heart disease.

scholarly journals Changes in Serum Natriuretic Peptide Levels after Percutaneous Closure of Small to Moderate Ventricular Septal Defects

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Yuksel Kaya ◽  
Ramazan Akdemir ◽  
Huseyin Gunduz ◽  
Sani Murat ◽  
Orhan Bulut ◽  
...  
Keyword(s):  
Ventricular Septal Defect ◽  
Brain Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Septal Defect ◽  
Percutaneous Closure ◽  
Specific Marker ◽  
Ventricular Septal Defects ◽  
Significant Adverse Event ◽  
Septal Defects ◽  
Ventricular Septal Defect Closure

Background. B-type natriuretic peptide has been shown to be a very sensitive and specific marker of heart failure. In this study, we aimed to investigate the effect of percutaneous closure of ventricular septal defects with Amplatzer septal occluders on brain natriuretic peptide levels.Methods. Between 2008 and 2011, 23 patients underwent successfully percutaneous ventricular septal defect closure in 4 cardiology centers. Brain natriuretic peptide levels were measured in nine patients (4 male, mean ages were ) who underwent percutaneous closure with Amplatzer occluders for membranous or muscular ventricular septal defects were enrolled in the study. Brain natriuretic peptide levels were measured one day before and one month after the closure. Patients were evaluated clinically and by echocardiography one month after the procedure.Results. Percutaneous closures of ventricular septal defects were successfully performed in all patients. There was not any significant adverse event in patients group during followup. Decrease in brain natriuretic peptide levels after closure were statistically significant ( versus , ).Conclusion. Brain Natriuretic Peptide levels are elevated in patients with ventricular septal defects as compared to controls. Percutaneous closure of Ventricular Septal Defect with Amplatzer occluders decreases the BNP levels.

scholarly journals Diagnostic Value of Plasma Levels of Brain Natriuretic Peptide in Arrhythmogenic Right Ventricular Dysplasia

Circulation ◽  
1998 ◽  
Vol 98 (22) ◽  
pp. 2433-2440 ◽  
Author(s):  
Kiyotaka Matsuo ◽  
Toshio Nishikimi ◽  
Chikao Yutani ◽  
Takashi Kurita ◽  
Wataru Shimizu ◽  
...  
Keyword(s):  
Brain Natriuretic Peptide ◽  
Right Ventricular ◽  
Natriuretic Peptide ◽  
Plasma Levels ◽  
Arrhythmogenic Right Ventricular Dysplasia ◽  
Diagnostic Value ◽  
Right Ventricular Dysplasia

scholarly journals Acute cardiac dyspnea in the emergency department: diagnostic value of N-terminal prohormone of brain natriuretic peptide and galectin-3

2018 ◽  
Vol 47 (1) ◽  
pp. 159-172 ◽  
Author(s):  
Alexandra Stoica ◽  
Victoriţa Şorodoc ◽  
Cătălina Lionte ◽  
Irina M. Jaba ◽  
Irina Costache ◽  
...  
Keyword(s):  
Emergency Department ◽  
High Risk ◽  
Brain Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Clinical Manifestations ◽  
Diagnostic Value ◽  
Left Ventricular ◽  
Diagnostic Methods ◽  
Left Ventricular Ejection ◽  
Galectin 3

Objective This study was performed to determine whether a dual-biomarker approach using N-terminal prohormone of brain natriuretic peptide (NT-proBNP) and galectin-3 optimizes the diagnosis and risk stratification of acute cardiac dyspnea. Atypical clinical manifestations and overlapping pathologies require objective and effective diagnostic methods to avoid treatment delays. Methods This prospective observational study included 208 patients who presented to the emergency department for acute dyspnea. NT-proBNP and galectin-3 were measured upon admission. The patients were divided into two groups according to the etiology of their clinical manifestations: cardiac and non-cardiac dyspnea. The patients’ New York Heart Association functional class, left ventricular ejection fraction, and discharge status were assessed. Results Diagnostic criteria for acute heart failure were fulfilled in 61.1% of the patients. NT-proBNP and galectin-3 were strongly and significantly correlated. Receiver operating characteristic analysis revealed similar areas under the curve for both markers in the entire group of patients as well as in the high-risk subsets of patients. Conclusions The diagnostic performance of NT-proBNP and galectin-3 is comparable for both the total population and high-risk subsets. Galectin-3 adds diagnostic value to the conventional NT-proBNP in patients with acute cardiac dyspnea, and its utility is of major interest in uncertain clinical situations.

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