Investigating the relationship between MTHFR C677T polymorphism and deep venous thrombosis: A meta-analysis of genetic association studies

2013 ◽  
Vol 24 ◽  
pp. e43
Author(s):  
T. Koufakis ◽  
E. Zintzaras ◽  
I. Gabranis ◽  
D. Karangelis ◽  
S. Batalla ◽  
...  
Keyword(s):  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Genetic Association ◽  
Association Studies ◽  
Meta Analysis ◽  
Genetic Association Studies ◽  
Mthfr C677t ◽  
C677t Polymorphism ◽  
Mthfr C677t Polymorphism ◽  
The Relationship

scholarly journals Relation between Methylenetetrahydrofolate Reductase C677T and A1298C Polymorphisms and Migraine Susceptibility

2019 ◽  
Author(s):  
Vandana Rai ◽  
Pradeep Kumar
Keyword(s):  
Methylenetetrahydrofolate Reductase ◽  
Association Studies ◽  
Meta Analysis ◽  
Asian Population ◽  
Mthfr C677t ◽  
Mthfr Gene ◽  
Genetic Models ◽  
C677t Polymorphism ◽  
Case Control Studies ◽  
Mthfr C677t Polymorphism

AbstractMigraine is a neurological disorder which impairs the patient’s quality of life. Several association studies investigating the association between MTHFR gene C677T and A1298C polymorphisms and susceptibility to migraine were published. But the results were conflicting, so authors performed a meta-analysis of published case control studies. Four databases were searched for suitable studies up to December, 2018. Odds ratios (OR) with 95% confidence intervals (CI) was calculated adopting additive, homozygote, co-dominant, dominant, and recessive genetic models.Results of MTHFR C677T polymorphism studies meta-analysis showed significant association with migraine risk using allele contrast, homozygote, dominant and recessive genetic models (T vs. C: OR = 1.18, 95%CI = 1.00-1.26, p= 0.05; TT vs. CC: OR = 1.24, 95%CI = 1.0-1.5, p= 0.04; CT vs. CC: OR = 1.08, 95%CI = 0.97-1.07, p= 0.25; TT+CT vs. CC: OR = 1.15, 95%CI = 1.0-1.29, p= 0.04; TT vs. CT +CC: OR = 1.97, 95%CI = 1.28-3.42, p= 0.002). However, results of MTHFR A1298 polymorphism studies meta-analysis did not show any association with migraine. Subgroup analysis based on ethnicity and migraine types i. e migraine with aura (MA) and without aura (MO) were also performed. Results of present meta-analysis indicate overall association between MTHFR C677T polymorphism with migraine in total 24 studies, in Asian population and in MA cases but did not show any association with Caucasian population and MO cases.

scholarly journals MTHFR C677T polymorphism and osteoporotic fracture in postmenopausal women: a meta-analysis

2014 ◽  
Vol 13 (3) ◽  
pp. 7356-7364 ◽  
Author(s):  
J.Z. Guan ◽  
M. Wu ◽  
Y.Z. Xiao ◽  
J.S. Zhou ◽  
Z.D. Wang
Keyword(s):  
Postmenopausal Women ◽  
Osteoporotic Fracture ◽  
Meta Analysis ◽  
Mthfr C677t ◽  
C677t Polymorphism ◽  
Mthfr C677t Polymorphism

scholarly journals Gene-Gene and Gene-Environment Interactions in Meta-Analysis of Genetic Association Studies

PLoS ONE ◽  
2015 ◽  
Vol 10 (4) ◽  
pp. e0124967 ◽  
Author(s):  
Chin Lin ◽  
Chi-Ming Chu ◽  
John Lin ◽  
Hsin-Yi Yang ◽  
Sui-Lung Su
Keyword(s):  
Genetic Association ◽  
Association Studies ◽  
Meta Analysis ◽  
Genetic Association Studies ◽  
Gene Environment

MTHFR C677T polymorphism associated with breast cancer susceptibility: a meta-analysis involving 15,260 cases and 20,411 controls

2010 ◽  
Vol 123 (2) ◽  
pp. 549-555 ◽  
Author(s):  
Jian Zhang ◽  
Li-Xin Qiu ◽  
Zhong-Hua Wang ◽  
Xiang-Hua Wu ◽  
Xiao-Jian Liu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Susceptibility ◽  
Meta Analysis ◽  
Mthfr C677t ◽  
Breast Cancer Susceptibility ◽  
C677t Polymorphism ◽  
Mthfr C677t Polymorphism

Collagen type-I A2 gene polymorphisms and susceptibility to intracranial aneurysms: a meta-analysis of genetic association studies

2017 ◽  
Vol 128 (7) ◽  
pp. 640-653
Author(s):  
Alexandros G. Brotis ◽  
Anastasia Tasiou ◽  
Theofanis Giannis ◽  
Athanasios Paschalis ◽  
Kostas N. Fountas
Keyword(s):  
Genetic Association ◽  
Gene Polymorphisms ◽  
Intracranial Aneurysms ◽  
Collagen Type ◽  
Association Studies ◽  
Meta Analysis ◽  
Genetic Association Studies ◽  
Collagen Type I ◽  
Type I

scholarly journals A systematic review and meta-analysis of genetic association studies for the role of inflammation and the immune system in diabetic nephropathy

2017 ◽  
Vol 10 (3) ◽  
pp. 293-300 ◽  
Author(s):  
Maria Tziastoudi ◽  
Ioannis Stefanidis ◽  
Georgios M. Hadjigeorgiou ◽  
Konstantinos Stravodimos ◽  
Elias Zintzaras
Keyword(s):  
Systematic Review ◽  
Diabetic Nephropathy ◽  
Immune System ◽  
Genetic Association ◽  
Association Studies ◽  
Meta Analysis ◽  
Genetic Association Studies

scholarly journals Meta-analysis of genetic association studies under heterogeneity

2012 ◽  
Vol 20 (11) ◽  
pp. 1174-1181 ◽  
Author(s):  
Binod Neupane ◽  
Mark Loeb ◽  
Sonia S Anand ◽  
Joseph Beyene
Keyword(s):  
Genetic Association ◽  
Association Studies ◽  
Meta Analysis ◽  
Genetic Association Studies
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