scholarly journals Synthesis and preliminary mechanistic evaluation of 5-(p-tolyl)-1-(quinolin-2-yl)pyrazole-3-carboxylic acid amides with potent antiproliferative activity on human cancer cell lines

2014 ◽  
Vol 87 ◽  
pp. 140-149 ◽  
Author(s):  
Şeyma Cankara Pirol ◽  
Burcu Çalışkan ◽  
İrem Durmaz ◽  
Rengül Atalay ◽  
Erden Banoglu
Keyword(s):  
Carboxylic Acid ◽  
Cell Lines ◽  
Cancer Cell ◽  
Antiproliferative Activity ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
Carboxylic Acid Amides

An IMDAF approach to annellated 1,4:5,8-diepoxynaphthalenes and their metathesis reaction leading to novel scaffolds displaying an antiproliferative activity toward cancer cells

2021 ◽  
Author(s):  
Elizaveta A. Kvyatkovskaya ◽  
Kseniya K. Borisova ◽  
Polina P. Epifanova ◽  
Aleksey A. Senin ◽  
Victor N. Khrustalev ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Cell Lines ◽  
Cancer Cell ◽  
Antiproliferative Activity ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Metathesis Reaction ◽  
Human Cancer Cell Lines ◽  
Antiproliferative Agent

A 3,5a-epoxyfuro[2,3,4-de]isoquinoline scaffold, the product of ROCM of 1,4:5,8-diepoxynaphthalenes, is a promising antiproliferative agent toward breast and prostate human cancer cell lines.

scholarly journals Synthetic Sphingolipids with 1,2-Pyridazine Appendages Improve Antiproliferative Activity in Human Cancer Cell Lines

2020 ◽  
Vol 11 (5) ◽  
pp. 686-690 ◽  
Author(s):  
Sylvestre P. J. T. Bachollet ◽  
Vito Vece ◽  
Alison N. McCracken ◽  
Brendan T. Finicle ◽  
Elizabeth Selwan ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Antiproliferative Activity ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines

Antiproliferative effect of synthetic cyclic imides (methylphtalimides, carboxylic acid phtalimides and itaconimides) against human cancer cell lines

2016 ◽  
Vol 71 (11-12) ◽  
pp. 423-427 ◽  
Author(s):  
Dorimar Stiz ◽  
Adriana Campos ◽  
Ana Lúcia Tasca Gois Ruiz ◽  
João Ernesto de Carvalho ◽  
Rogério Corrêa ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Tumor Cell Line ◽  
Cancer Cell Lines ◽  
Antiproliferative Effect ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
Cyclic Imides

Abstract This work describes the antiproliferative potential of 14 cyclic imides (methylphtalimides, carboxylic acid phtalimides and itaconimides) against several human cancer cell lines. The antiproliferative effect was evaluated using the sulforhodamine B assay. Although some compounds from methylphtalimide and carboxylic acid phtalimide classes exhibited a selective antiproliferative activity, the itaconimides (11–14) exhibited the best results, especially compound 14, which presented a TGI (concentration that produces total growth inhibition) value of 0.0043 μM against glioma (U251), being inactive against the non-tumor cell line (HaCat). Absorption, distribution, metabolism and excretion in silico evaluations suggest that these compounds are promising candidates.

Antiproliferative activity of Hungarian Asteraceae species against human cancer cell lines. Part II

2009 ◽  
Vol 23 (8) ◽  
pp. 1109-1115 ◽  
Author(s):  
Boglárka Csupor-Löffler ◽  
Zsuzsanna Hajdú ◽  
Borbála Réthy ◽  
István Zupkó ◽  
Imre Máthé ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Antiproliferative Activity ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines

Synthesis of 4-(4-Methylidene-4H-3,1-Benzothiazin-2-yl)benzene-1,3-Diols and Their Antiproliferative Activity Against Human Cancer Cell Lines

2016 ◽  
Vol 42 (1) ◽  
pp. 104-110
Author(s):  
J. Matysiak ◽  
A. Skrzypek ◽  
A. Niewiadomy ◽  
M. M. Karpińska ◽  
J. Wietrzyk ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Antiproliferative Activity ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines

Pyrazole–oxadiazole conjugates: synthesis, antiproliferative activity and inhibition of tubulin polymerization

2014 ◽  
Vol 12 (40) ◽  
pp. 7993-8007 ◽  
Author(s):  
Ahmed Kamal ◽  
Anver Basha Shaik ◽  
Sowjanya Polepalli ◽  
Vangala Santosh Reddy ◽  
G. Bharath Kumar ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Antiproliferative Activity ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Tubulin Polymerization ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines

A library of pyrazole–oxadiazole conjugates were synthesized and investigated for their antiproliferative activity in human cancer cell lines.

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