Doxorubicin-loaded oligonucleotide conjugated gold nanoparticles: A promising in vivo drug delivery system for colorectal cancer therapy

2017 ◽  
Vol 142 ◽  
pp. 416-423 ◽  
Author(s):  
Chang-Seuk Lee ◽  
Hyungjoo Kim ◽  
Joonhee Yu ◽  
Su Hwan Yu ◽  
Seona Ban ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Drug Delivery ◽  
Gold Nanoparticles ◽  
Cancer Therapy ◽  
Drug Delivery System ◽  
Delivery System

scholarly journals Novel concept of the smart NIR-light–controlled drug release of black phosphorus nanostructure for cancer therapy

2018 ◽  
Vol 115 (3) ◽  
pp. 501-506 ◽  
Author(s):  
Meng Qiu ◽  
Dou Wang ◽  
Weiyuan Liang ◽  
Liping Liu ◽  
Yin Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Near Infrared ◽  
Black Phosphorus ◽  
Deep Penetration ◽  
Nir Light

A biodegradable drug delivery system (DDS) is one the most promising therapeutic strategies for cancer therapy. Here, we propose a unique concept of light activation of black phosphorus (BP) at hydrogel nanostructures for cancer therapy. A photosensitizer converts light into heat that softens and melts drug-loaded hydrogel-based nanostructures. Drug release rates can be accurately controlled by light intensity, exposure duration, BP concentration, and hydrogel composition. Owing to sufficiently deep penetration of near-infrared (NIR) light through tissues, our BP-based system shows high therapeutic efficacy for treatment of s.c. cancers. Importantly, our drug delivery system is completely harmless and degradable in vivo. Together, our work proposes a unique concept for precision cancer therapy by external light excitation to release cancer drugs. If these findings are successfully translated into the clinic, millions of patients with cancer will benefit from our work.

99mTc-citrate-gold nanoparticles as a tumor tracer: synthesis, characterization, radiolabeling and in-vivo studies

2020 ◽  
Vol 108 (10) ◽  
pp. 809-819 ◽  
Author(s):  
Basma M. Essa ◽  
Ahmed A. El-Mohty ◽  
Maher A. El-Hashash ◽  
Tamer M. Sakr
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticles ◽  
Drug Delivery System ◽  
Delivery System ◽  
Solid Tumor ◽  
Tumor Imaging ◽  
In Vivo Studies ◽  
Post Injection ◽  
Tumor Bearing

AbstractTargeted drug delivery system can reduce the side effects of high drug concentration by improving drug pharmacokinetics at lower doses. Citrate-gold nanoparticles (AuNPs) as a drug delivery system were synthesized via green nanotechnology technique to be used as a new imaging platform for tumor targeting. Citrate-AuNPs were synthesized with core size of 10 nm. Citrate-AuNPs were labeled with technetium-99m (99mTc) with radiochemical yield of 95.20 ± 2.70% with good in-vitro stability in both saline and human serum and well in-vivo studied in both normal and solid tumor bearing mice. The in-vivo biodistribution study of [99mTc]Tc-citrate-AuNPs in solid tumor bearing mice (as preliminary study) showed a high accumulation in tumor site with tumor/muscle of 4.35 ± 0.22 after 30 min post injection. The direct intratumoral (I.T) injection of [99mTc]Tc-citrate-AuNPs showed that this complex was retained in the tumor up to 77.86 ± 1.90 % at 5 min and still around 50.00 ± 1.42 % after 30 min post injection (p.i.). The newly presented nano-platform could be presented as a new potential radiopharmaceutical tumor imaging probe.

scholarly journals Genetic engineering of a probiotic-based drug delivery system for colorectal cancer therapy

2020 ◽  
Vol 4 (2) ◽  
Author(s):  
Byung Chull An ◽  
Yongku Ryu ◽  
Oksik Choi ◽  
Sunwoong Hong ◽  
Jin Young Heo ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Drug Delivery ◽  
Cancer Therapy ◽  
Genetic Engineering ◽  
Drug Delivery System ◽  
Delivery System

Gx1-conjugated endostar nanoparticle: a new drug delivery system for anti-colorectal cancer in vivo

2014 ◽  
Author(s):  
Qian Zhang ◽  
Yang Du ◽  
Yaqian Li ◽  
Xiaolong Liang ◽  
Xin Yang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
New Drug

scholarly journals Application of Marine-Based Gold Nanomaterials in Cancer Therapy: A Mini-Review

2021 ◽  
Author(s):  
Neda Baghban ◽  
Arezoo Khoradmehr ◽  
Iraj Nabipour ◽  
Amin Tamadon
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticles ◽  
Cancer Therapy ◽  
Drug Delivery System ◽  
Delivery System ◽  
Medical Sciences ◽  
Gold Nanocomposites ◽  
Marine Natural Compound ◽  
Gold Nanomaterials ◽  
Near Future

Cancer is one of the health concerns in modern societies. The application of nanotechnology in medical sciences has created new possibilities for the diagnosis, imaging and the treatment of tumors in humans. The present article reviews the application of marine-based gold nanoparticles in diagnosing and treating cancer. The main data were collected from research article on the application of different marine-based gold nanoparticles in detecting and imaging cancer cells as well as in drug delivery system in treatment of cancer. Chitosan is the most used marine natural compound used to fabricate gold nanocomposites and the most reported application of this type of nano-composites is related to drug delivery system. Despite the excellent anticancer potential of different marine natural products, less studies have been conducted on the use of their compositions with gold nanoparticles in cancer therapy than other materials. Moreover, most reports available in this filed are related to their application as a drug delivery system not anticancer drug. In general, there are still challenges and limitations to the use of nanoparticles in medicine, it is hoped that in the near future nanoparticles will create a dramatic revolution not only in oncology but also in medicine.

Saponin loaded montmorillonite-human serum albumin nanocomposites as drug delivery system in colorectal cancer therapy

2018 ◽  
Vol 166 ◽  
pp. 214-222 ◽  
Author(s):  
Oznur Akbal ◽  
Tayfun Vural ◽  
Soheil Malekghasemi ◽  
Betül Bozdoğan ◽  
Emir Baki Denkbaş
Keyword(s):  
Colorectal Cancer ◽  
Drug Delivery ◽  
Cancer Therapy ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Drug Delivery System ◽  
Delivery System
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