Umbilical cord plasma concentrations of free morphine following single-dose diamorphine analgesia and their relationship to dose-delivery time interval, Apgar scores and neonatal respiration

2007 ◽  
Vol 133 (1) ◽  
pp. 30-33 ◽  
Author(s):  
N. Rawal ◽  
A.J. Tomlinson ◽  
G.J. Gibson ◽  
T.M.T. Sheehan
Keyword(s):  
Single Dose ◽  
Umbilical Cord ◽  
Plasma Concentrations ◽  
Time Interval ◽  
Delivery Time ◽  
Dose Delivery ◽  
Apgar Scores ◽  
Cord Plasma

N-terminal pro-C-type natriuretic peptide, but not C-type natriuretic peptide, is greatly elevated in the fetal circulation

2004 ◽  
Vol 106 (5) ◽  
pp. 535-540 ◽  
Author(s):  
Timothy C. R. PRICKETT ◽  
Risto J. KAAJA ◽  
M. Gary NICHOLLS ◽  
Eric A. ESPINER ◽  
A. Mark RICHARDS ◽  
...  
Keyword(s):  
Cord Blood ◽  
Natriuretic Peptide ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Plasma Concentrations ◽  
Maternal Plasma ◽  
Fetal Tissues ◽  
Cord Plasma ◽  
Significant Difference ◽  
Gestational Group

We have identified recently a new peptide, NT-proCNP(1–50) (N-terminal pro-C-type natriuretic peptide), in the circulation of humans and sheep. A previous report of an elevated fetal–maternal gradient in immunoreactive CNP raised the possibility that processing and metabolism of proCNP may differ in maternal and fetal tissues. We therefore collected matching peripheral maternal and umbilical cord plasma samples at delivery from women with normotensive and pre-eclamptic pregnancies to investigate the presence and concentrations of CNP and NT-proCNP using HPLC and RIA. Plasma concentrations of NT-proCNP in normotensive umbilical cord plasma were 10-fold higher than maternal venous levels (246±17 compared with 24.3±1.8 pmol/l; P<0.001) and much higher than corresponding levels of CNP (3.6±0.4 compared with 1.8±0.3 pmol/l in the fetal and maternal plasma respectively; P<0.001). Although there was no significant difference between normotensive and pre-eclamptic plasma CNP concentrations in either maternal or umbilical cord blood, NT-proCNP showed a significant statistical interaction (F=5.8, P=0.025) between the source (maternal or fetal) and gestational group (normotensive or pre-eclamptic). Maternal NT-proCNP levels were raised in the pre-eclampsia group, whereas the converse was observed in umbilical cord blood. In conclusion, the greatly elevated ratio of NT-proCNP/CNP in fetal compared with maternal plasma suggests that synthesis, as well as clearance, of CNP (but not NT-proCNP clearance) are markedly increased in fetal tissues.

scholarly journals Plasma Concentrations and Maternal-Umbilical Cord Plasma Ratios of the Six Most Prevalent Carotenoids across Five Groups of Birth Gestational Age

Antioxidants ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 1409
Author(s):  
Chelsey McConnell ◽  
Melissa Thoene ◽  
Matthew Van Ormer ◽  
Jeremy D. Furtado ◽  
Zeljka Korade ◽  
...  
Keyword(s):  
Umbilical Cord ◽  
Gestational Age ◽  
Plasma Concentrations ◽  
Newborn Infants ◽  
Maternal Plasma ◽  
P Value ◽  
Limited Information ◽  
Factors Associated ◽  
Cord Plasma ◽  
Β Carotene

Carotenoids are antioxidant nutrients with the potential to provide protection against oxidative stress. Plasma carotenoid concentrations are lower in newborn infants compared to their mothers; however, limited information is available regarding how concentrations differ by gestational age. The objective of this research is to assess maternal and umbilical cord plasma carotenoid concentrations and maternal-umbilical cord plasma ratios across five groups of birth gestational age. Mother-infant dyads were enrolled at delivery for collection of maternal and umbilical cord blood. Plasma carotenoids were analyzed by HPLC and LC-MS/MS. Birth gestational age was categorized into five groups, and the Kruskal–Wallis test compared carotenoid concentrations and maternal-umbilical cord plasma ratios between these groups. A p-value of < 0.05 was considered statistically significant. 370 mother-infant dyads were included, with most infants delivered at early term (20.3%) or term (64.6%). Though maternal plasma concentrations increased with birth gestational age, we observed less variability in umbilical cord plasma concentrations, thus the maternal-umbilical cord plasma ratio also increased with birth CGA groups for lutein + zeaxanthin (p = 0.008), β-cryptoxanthin (p = 0.027), α-carotene (p = 0.030); β-carotene approached significance (p = 0.056). Additional research is needed to determine if carotenoid concentrations were physiologic to varying gestational ages or if they were impacted by factors associated with preterm birth.

The Influence of Dose-Delivery time Interval on Neonatal Plasma Pethidine Levels

1983 ◽  
Vol 62 (6) ◽  
pp. 549-553 ◽  
Author(s):  
Terence A. Moreland ◽  
John E. H. Brice ◽  
Omar Mohamdee ◽  
Colin H. M. Walker
Keyword(s):  
Time Interval ◽  
Delivery Time ◽  
Dose Delivery

Umbilical cord plasma concentrations of deoxycorticosterone sulfate in anencephalic fetuses

1984 ◽  
Vol 150 (6) ◽  
pp. 754-757 ◽  
Author(s):  
C.R. Parker ◽  
B.R. Carr ◽  
C.A. Winkel ◽  
M.L. Casey ◽  
P.C. MacDonald
Keyword(s):  
Umbilical Cord ◽  
Plasma Concentrations ◽  
Cord Plasma

scholarly journals Clinical chorioamnionitis at term V: umbilical cord plasma cytokine profile in the context of a systemic maternal inflammatory response

2015 ◽  
Vol 0 (0) ◽  
Author(s):  
Roberto Romero ◽  
Piya Chaemsaithong ◽  
Nikolina Docheva ◽  
Steven J. Korzeniewski ◽  
Adi L. Tarca ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Amniotic Fluid ◽  
Umbilical Cord ◽  
Plasma Concentrations ◽  
Cytokine Profile ◽  
Ionization Mass ◽  
Cross Sectional ◽  
Plasma Cytokine ◽  
Microbial Invasion ◽  
Cord Plasma

AbstractMicrobial invasion of the fetus due to intra-amniotic infection can lead to a systemic inflammatory response characterized by elevated concentrations of cytokines in the umbilical cord plasma/serum. Clinical chorioamnionitis represents the maternal syndrome often associated with intra-amniotic infection, although other causes of this syndrome have been recently described. The objective of this study was to characterize the umbilical cord plasma cytokine profile in neonates born to mothers with clinical chorioamnionitis at term, according to the presence or absence of bacteria and/or intra-amniotic inflammation.A cross-sectional study was conducted, including patients with clinical chorioamnionitis at term (n=38; cases) and those with spontaneous term labor without clinical chorioamnionitis (n=77; controls). Women with clinical chorioamnionitis were classified according to the results of amniotic fluid culture, broad-range polymerase chain reaction coupled with electrospray ionization mass spectrometry (PCR/ESI-MS) and amniotic fluid interleukin (IL)-6 concentration into three groups: 1) no intra-amniotic inflammation; 2) intra-amniotic inflammation without detectable microorganisms; or 3) microbial-associated intra-amniotic inflammation. A fetal inflammatory response syndrome (FIRS) was defined as an umbilical cord plasma IL-6 concentration >11 pg/mL. The umbilical cord plasma concentrations of 29 cytokines were determined with sensitive and specific V-PLEX immunoassays. Nonparametric statistical methods were used for analysis, adjusting for a false discovery rate of 5%.1) Neonates born to mothers with clinical chorioamnionitis at term (consideredNeonates born to mothers with clinical chorioamnionitis at term had higher concentrations of umbilical cord plasma cytokines than those born to mothers without clinical chorioamnionitis. Even neonates exposed to clinical chorioamnionitis but not to intra-amniotic inflammation had elevated concentrations of multiple cytokines, suggesting that intrapartum fever alters the fetal immune response.

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