A randomized study comparing triptorelin or expectant management following conservative laparoscopic surgery for symptomatic stage III–IV endometriosis

Objective To compare the efficacy of postoperative adjuvant treatment (gonadotropin-releasing hormone agonists [GnRHas] and oral contraceptives [OCs]) and expectant treatment in preventing recurrent dysmenorrhea following conservative laparoscopic surgery for deep infiltrating endometriosis (DIE) with dysmenorrhea. Methods A prospective cohort study was conducted in Shanghai, China. In total, 147 patients with dysmenorrhea who underwent conservative laparoscopic surgery for DIE were enrolled. Following surgery, patients received either postoperative adjuvant therapy (GnRHa or OCs) for 6 months or expectant treatment according to a shared medical decision-making approach. The primary outcome was the postoperative recurrence of dysmenorrhea. The secondary outcomes included reproductive outcomes and drug-induced side effects. Results The generalized estimating equation analysis illustrated that the visual analog scale for dysmenorrhea was significantly higher in the adjuvant treatment group than in the expectant treatment group. Kaplan–Meier analysis and the log-rank test demonstrated that the cumulative recurrence rate was higher in the expectant treatment group than in the adjuvant treatment group, but no difference was noted between the two hormonal treatments. Similar cumulative 24-month clinical pregnancy rates were observed among the three groups. Conclusions Compared with expectant management, postoperative medical treatment more effectively relieved symptoms and prevented the recurrence of dysmenorrhea.

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A prospective randomized study of adjuvant chemotherapy in completely resected stage III-N2 non small cell lung cancer

Chinese Journal of Cancer Research ◽

10.1007/s11670-007-0189-z ◽

2007 ◽

Vol 19 (3) ◽

pp. 189-194 ◽

Cited By ~ 3

Author(s):

Si-yu Wang ◽

Wei Ou ◽

Yong-bin Lin ◽

Ying Liang ◽

Xiong Ye ◽

...

Keyword(s):

Lung Cancer ◽

Adjuvant Chemotherapy ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Randomized Study ◽

Small Cell ◽

Stage Iii ◽

Prospective Randomized Study ◽

Small Cell Lung ◽

Resected Stage

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Dienogest is as effective as triptorelin in the treatment of endometriosis after laparoscopic surgery: results of a prospective, multicenter, randomized study

Fertility and Sterility ◽

10.1016/s0015-0282(01)03270-8 ◽

2002 ◽

Vol 77 (4) ◽

pp. 684-692 ◽

Cited By ~ 98

Author(s):

Michel Cosson ◽

Denis Querleu ◽

Jacques Donnez ◽

Patrick Madelenat ◽

Philippe Konincks ◽

...

Keyword(s):

Laparoscopic Surgery ◽

Randomized Study

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The role of radiation therapy in the management of stage III follicular lymphomas.

Journal of Clinical Oncology ◽

10.1200/jco.1984.2.7.841 ◽

1984 ◽

Vol 2 (7) ◽

pp. 841-848 ◽

Cited By ~ 52

Author(s):

S B Paryani ◽

R T Hoppe ◽

R S Cox ◽

T V Colby ◽

H S Kaplan

Keyword(s):

Radiation Therapy ◽

Adjuvant Chemotherapy ◽

Randomized Study ◽

Maximum Size ◽

Large Cell ◽

Stage Iii ◽

Whole Body ◽

Actuarial Survival ◽

Significant Difference ◽

Follicular Lymphomas

Between 1961 and 1982, 66 patients with stage III follicular small cleaved (FSC) and follicular mixed small cleaved and large cell (FM) lymphoma were treated at Stanford University. Treatment consisted of total-lymphoid irradiation (TLI) to a total dose of about 4,000 rad in 61 patients or whole-body irradiation (WBI) followed by boost irradiation to sites of involvement in five patients. In addition, 13 patients treated with TLI received adjuvant chemotherapy, consisting of six cycles of cyclophosphamide, vincristine, and prednisone (CVP). Median follow-up was 9.6 years. Kaplan-Meier actuarial survival at five, ten, and 15 years was 78%, 50%, and 37%, respectively. Freedom from relapse at five and ten years was 60% and 40% with no relapses after ten years. In a prospective randomized study of 16 patients who all underwent staging laparotomy comparing TLI with or without adjuvant chemotherapy with CVP, there was no significant difference in either survival or freedom from relapse between the two groups. Patients with limited stage III disease (without B symptoms, less than five sites of involvement, and maximum size of disease less than 10 cm) had an excellent prognosis with a 15-year survival and freedom from relapse of 100% and 88%, respectively. Radiation therapy may be a potentially curative modality in patients with stage III follicular lymphomas.

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