A novel partial agonist of GPBA reduces blood glucose level in a murine glucose tolerance test

2017 ◽  
Vol 814 ◽  
pp. 130-137 ◽  
Author(s):  
Rina Enomoto ◽  
Aya Kurosawa ◽  
Yoshiaki Nikaido ◽  
Misaki Mashiko ◽  
Toshihiko Saheki ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Glucose Tolerance ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Glucose Tolerance Test ◽  
Partial Agonist ◽  
Tolerance Test

scholarly journals Effect of Afghan Talkhak (Acroptilon Repens) Aqueous Extract on Blood Glucose Level in Diabetic Rats

2021 ◽  
Vol 12 (2) ◽  
pp. 275-279
Author(s):  
Banafsha Zainal Bayat ◽  
Kawsar Alami ◽  
Sayed Yousof Mousavi
Keyword(s):  
Blood Glucose ◽  
Glucose Tolerance ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Aqueous Extract ◽  
Glucose Tolerance Test ◽  
Tolerance Test ◽  
Diabetic Rats ◽  
Diabetic Group ◽  
Acroptilon Repens

The aim of this study is the evaluation of the effect of Afghan talkhak (Acroptilon Repens) root aqueous extract on blood glucose level of diabetic rats. Rats were randomly divided into 5 groups (1 Normal, 1 Diabetic and 3 extract groups). Experimental diabetes was induced by single-dose intraperitoneal (i.p.) injection of streptozotocin (55 mg/kg) in diabetic and extracts groups. 72 hour later, the induction of diabetes was approved and extract groups were received Acroptilon Repens aqueous extract (200, 300, 400 mg/kg) by i.p. administration for 15 days. The blood glucose level and body weight of all groups were measured on baseline, 0, 5, 10 and 15th days. The glucose tolerance test had performed on days 0 and 15. The results showed that aqueous extract of Afghan Acroptilon Repens in extract groups (200 and 300 mg/kg) could significantly decrease the blood glucose level, and improve the glucose tolerance, as compared with the diabetic group (P<0.0001). However, there was not a significant difference in the blood glucose level and glucose tolerance test among the group which received 400 mg/kg dose of Acroptilon Repens and the diabetic group (P>0.05). In conclusion, Acroptilon Repens root aqueous extract possessed antihyperglycemic activity. 

scholarly journals Lactobacillus rhamnosus Reduces Blood Glucose Level through Downregulation of Gluconeogenesis Gene Expression in Streptozotocin-Induced Diabetic Rats

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Eko Farida ◽  
Lilis Nuraida ◽  
Puspo E. Giriwono ◽  
Betty S. L. Jenie
Keyword(s):  
Blood Glucose ◽  
Glucose Tolerance ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Fasting Blood Glucose ◽  
Lactobacillus Rhamnosus ◽  
Tolerance Test ◽  
Diabetic Rats ◽  
The Body ◽  
Oral Glucose

Some lactic acid bacteria (LAB) are observed to be potential probiotics with functional properties such as lowering fasting blood glucose (FBG), as a promising hyperglycemia management. This study investigated the ability and mechanism of Lactobacillus rhamnosus BSL and Lactobacillus rhamnosus R23 on lowering FBG in diabetic rats induced by streptozotocin (STZ). The rats were orally administered with L. rhamnosus BSL and L. rhamnosus R23 by giving 1 mL cell suspension (109 CFU/mL) daily for 30 days. The body weight (BW) was recorded once in three days, and FBG was recorded once in six days. An oral glucose tolerance test (OGTT) was measured 1 week after injection with STZ and before sacrifice. Fecal samples were collected on days 0, 15, and 30 for LAB population and identification, performed by PCR detecting 16S rRNA. Oral administration of L. rhamnosus BSL and L. rhamnosus R23 decreased FBG and improved glucose tolerance via downregulation of glucose-6-phosphatase (G6pc) expression by 0.57- and 0.60-fold change, respectively (P<0.05). The lipid profiles, BUN, creatinine, SGOT, and SGPT were significantly (P<0.05) different between normal and diabetic rats, but they were not significantly (P>0.05) different among diabetic rats. Both strains were effective in increasing fecal LAB population. Molecular identification of the isolated LAB from fecal sample indicated that they were able to survive and pass through the digestive tract. These results suggested that both strains have the ability to manage blood glucose level and become a promising agent to manage hyperglycemia and diabetes.

The evaluation of the agreement between fasting glycemia at the first prenatal visit and the results of the glucose tolerance test in diagnostics of gestational diabetes mellitus

2014 ◽  
Vol 60 (5) ◽  
pp. 9-14 ◽  
Author(s):  
P V Popova ◽  
A V Dronova ◽  
E R Sadikova ◽  
M P Parkkinen ◽  
M V Bol’shakova ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Glucose Tolerance Test ◽  
Fasting Blood Glucose ◽  
Tolerance Test ◽  
Fasting Blood Glucose Level ◽  
Prenatal Visit ◽  
Fasting Glycemia ◽  
The Mean

Objective. To evaluate the importance of determining fasting glycemia at the first prenatal visit for timely diagnostics of gesta- tional diabetes mellitus (GDM). Material and methods. The study included 577 pregnant women examined with the use of the oral glucose tolerance test (OGTT) during weeks 24-28 of pregnancy. The results of the test were compared with the fasting glucose level at the first prenatal visit. Results. The mean fasting blood glucose level at the first prenatal visit was 4.70±0.61 mmol/l. In 25% of the patients, fasting glycemia at this time was 5.1 mmol/l or higher. Only in 36% of the women (52 of the145 ones) with the fasting blood glucose level ≥5.1 and <7 mmol/l at the first prenatal visit, the results of OGTT were consistent with the criteria for GDM. The mean fasting blood glucose level at the first prenatal visit (up to week 16) was significantly higher than on weeks 24-28 (4.71±0.61 and 4.53±0.69 mmol/l respectively, p<0.001). The ROC analysis failed to reveal the fasting blood glucose level that could be used to predict the development of gestational diabetes with a reliable sensitivity and specific- ity. Conclusion. Further population-based investigations are needed to elucidate the relationship between fasting glycemia in the first trimester of pregnancy and its unfavourable outcome.

scholarly journals SCREENING & EVALUATION OF ANTI-DIABETIC SPECTRUM OF WITHANIA COAGULANS

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Mayank Bansal ◽  
Sweta Kumari ◽  
Yogesh Kumar Sharma
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Glucose Tolerance ◽  
Glucose Level ◽  
Glucose Tolerance Test ◽  
Tolerance Test ◽  
Diabetic Rats ◽  
Antidiabetic Effect ◽  
Withania Coagulans

Diabetes mellitus is a metabolic disorder. This review article is planned to The anti-diabetic effect of Withania Coagulans have been successfully used in Ayurvedic and other traditional formulations and found to be efficient and inexpensive as compared to synthetic drugs. It also aims to test and verify the W. coagulans fruits, showed significant inhibition on postprandial rise in hyperglycemia post-sucrose load in normoglycemic rats as well as streptozotocin-induced diabetic rats. which is comparable to the standard antidiabetic drug Glibenclamide for medical care, The present study defines the systematic evaluation and the role of minerals in glycemic potential of aqueous extract of Withania coagulans fruits in order to develop an effective and safe alternative treatment for diabetes mellitus. These studies conducted to determine the antidiabetic effect of Withania coagulans and pancreatic histological features in streptozotocin induced diabetic rat. Results: The study is based on results of lowering in blood glucose levels of normal, sub, mild diabetic rats assessed during fasting blood glucose, glucose tolerance test studies. The dose of 1000mg/kg was identified as the most effective dose, which reduce the blood glucose level maximum by 35.2% at 5 hours in normal rats during blood glucose studies. Glucose tolerance test studies is normal, sub and mild diabetic rats showed the maximum reduction of 16.7, 29.8 and 38.5% at 4hour respectively. Long term study incase of severely diabetic rats showed reduction fasting glucose level respectively after 30 days of treatment. The present study confirming antidiabetic effect of aqueous extract of Withania Coagulans, helps in identifying the role of trace minerals like Mg and Ca responsible for antidiabetic potential of this potent indigenous shrub. Conclusion: The present research has presented comprehensive details of antidiabetic plants used in the treatment of diabetes mellitus. Most of these plant derived medicines. Keywords: Anti-Diabetic effect, Screening & Evaluation, Streptozocin, Glibenclamide, Diabetic rats.

scholarly journals Pharmacological potential of methanol extract of Anacardium occidentale stem bark on alloxan-induced diabetic rats

2018 ◽  
Vol 5 (7) ◽  
pp. 2440-2454
Author(s):  
D. A. Omoboyowa ◽  
F. O. Afolabi ◽  
T. C. Aribigbola
Keyword(s):  
Blood Glucose ◽  
Glucose Tolerance ◽  
Glucose Tolerance Test ◽  
Methanol Extract ◽  
Stem Bark ◽  
Tolerance Test ◽  
Diabetic Rats ◽  
Oral Glucose ◽  
Oral Glucose Tolerance ◽  
Β Cells

Background: The anti-hyperglycemic potential of methanol stem bark extract of Anacardium occidentale (MSBEAO) was investigated using an alloxan-induced diabetic rat model. Alloxan administration induces the generation of free radicals which can affect antioxidant status resulting in the disruption of the β-cells of the pancreas. Therefore, this study examines the antioxidant potential of the plant extract and the ameliorating effect on the pancreas of alloxan-induced diabetic rats. Methods: Diabetes was induced by intraperitoneal injection of 150 mg/kg body weight of alloxan monohydrate. MSBEAO, at a concentration of 100 or 200 mg/kg b.w. was orally administered to alloxan-induced diabetic rats and normal rats. The hypoglycemic effect, oral glucose tolerance test, and biochemical assay of alloxan-induced diabetic rats were assayed using standard procedures. Results: Preliminary phytochemical screening of the extract revealed the presence of alkaloids, tannins, saponins, terpenoids, carbohydrates, and phenols at moderate concentrations. The lethality dose (LD50) of the plant extract was found to be equal to or less than 5000 mg/kg b.w. The hypoglycemic effect of the extract on the non-diabetic rats revealed a significant (p<0.05) decrease in the blood glucose concentration of animals administered with 1 g/kg b.w. of the extract, compared to normal control rats administered with normal saline. In the oral glucose tolerance test, the methanol extract exerted the highest response, similar to glibenclamide after 15 and 30 minutes of administration, compared to the control rats. The methanol extract yielded the highest blood glucose lowering effects after 9 days of treatment (p<0.05), compared to diabetic rats administered with normal saline and 0.3 mg/kg b.w. of glibenclamide. Administration of the extract at 200 mg/kg b.w. showed improved pancreas architecture and regeneration of the β-cells, compared with the pancreas of animals in the other groups. Conclusion: The results of this study suggest that MSBEAO is a potentially effective agent for the management of diabetes which might result from the antioxidant-generating capacity of the stem bark.

scholarly journals GESTATIONAL DIABETES MELLITUS

2012 ◽  
Vol 19 (04) ◽  
pp. 462-468
Author(s):  
M. IKRAM ◽  
SYED HAIDER HASAN ALAM ◽  
SHAFQAT MUKHTAR ◽  
M. Saeed
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Gestational Diabetes ◽  
Glucose Tolerance ◽  
Gestational Diabetes Mellitus ◽  
Glucose Tolerance Test ◽  
Fasting Blood Glucose ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Oral Glucose Tolerance

Introduction: Gestational diabetes mellitus is common disorder in pregnancy. It is associated with adverse pregnancy outcome. There is no consensus regarding the optimal approach to screening of gestational diabetes mellitus. The present study has tried toobserve the value of fasting blood glucose in screening of gestational diabetes. Objective: To determine the frequency of patients in whomfasting blood glucose and 100gm glucose tolerance show agreement for screening of gestational diabetes mellitus at 24 -28 wks. Studydesign: Comparative cross sectional study. Settings: The study was conducted at Gynecology and Obstetrics department Shaikh ZayedFederal Post Graduate Institute Lahore. Duration of study with dates: 6 months from 12Nov 2010 to 11 May 2011. Material and method: Thestudy included 135 booked patients with positive family history of diabetes mellitus. All patients underwent fasting blood glucose at 24-28 weeksof gestation, regardless of results of fasting blood glucose on next visit they underwent 100g oral glucose tolerance test (OGTT). The agreementbetween fasting blood glucose and 100g oral glucose tolerance test was calculated in frequency and percentages. Results: The mean age ofwomen in studied population was 27.15±3.70.Out of 135 patients 86.7 %( 117) showed agreement between results of fasting blood glucose and100g OGTT while 13.31 %( 18) showed no agreement between both of the tests. Conclusions: Fasting blood glucose is a good screeningoption for gestational diabetes mellitus along with positive history. It provides a simple, cheap and more practical test for screening of gestationaldiabetes mellitus. However diagnostic confirmation with 100g OGTT should be done.

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