scholarly journals RhoA and Rho-kinase inhibitors modulate cervical resistance: The possible role of RhoA/Rho-kinase signalling pathway in cervical ripening and contractility

2019 ◽  
Vol 843 ◽  
pp. 27-33 ◽  
Author(s):  
Dóra Domokos ◽  
Eszter Ducza ◽  
Róbert Gáspár
Keyword(s):  
Kinase Inhibitors ◽  
Rho Kinase ◽  
Signalling Pathway ◽  
Cervical Ripening ◽  
Rho Kinase Inhibitors ◽  
Cervical Resistance

scholarly journals The Role of Rho Kinase in Sex-Dependent Vascular Dysfunction in Type 1 Diabetes

2010 ◽  
Vol 2010 ◽  
pp. 1-11 ◽  
Author(s):  
Daniel W. Nuno ◽  
Kathryn G. Lamping
Keyword(s):  
Kinase Inhibitors ◽  
Vascular Dysfunction ◽  
Rho Kinase ◽  
Term Treatment ◽  
Compensatory Mechanisms ◽  
Rho Kinase Inhibitors ◽  
Long Term Treatment

We hypothesized that rho/rho kinase plays a role in sex differences in vascular dysfunction of diabetics. Contractions to serotonin were greater in isolated aortic rings from nondiabetic males versus females and increased further in streptozotocin-induced diabetic males but not females. The increased contractions to serotonin in males were reduced by inhibitors of rho kinase (fasudil, Y27632 and H1152) despite no change in expression of rhoA or rho kinase. Contractions to U46619 were not altered by fasudil or Y27632 or the presence of diabetes. In contrast to acute effects of fasudil, chronic treatment with fasudil increased contractions to serotonin in aorta from both non-diabetic and diabetic males. In summary, serotonin-induced contractions were increased in aorta from diabetic males but not females. Although administration of rho kinase inhibitors acutely decreased contractions to serotonin, long-term treatment with fasudil increased contractions. Long-term fasudil treatment may increase compensatory mechanisms to enhance vasoconstrictions.

Potential Role of Rho Kinase Inhibitors in Combating Diabetes-Related Complications Including Diabetic Neuropathy-A Review

2013 ◽  
Vol 9 (3) ◽  
pp. 249-266 ◽  
Author(s):  
Ram Kumar Mishra ◽  
Reshma Alokam ◽  
Dharmarajan Sriram ◽  
Perumal Yogeeswari
Keyword(s):  
Diabetic Neuropathy ◽  
Potential Role ◽  
Kinase Inhibitors ◽  
Rho Kinase ◽  
Rho Kinase Inhibitors

Acute lung injury: The therapeutic role of Rho kinase inhibitors

2020 ◽  
Vol 155 ◽  
pp. 104736 ◽  
Author(s):  
Farshad Abedi ◽  
A. Wallace Hayes ◽  
Russel Reiter ◽  
Gholamreza Karimi
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Kinase Inhibitors ◽  
Rho Kinase ◽  
Therapeutic Role ◽  
Rho Kinase Inhibitors

Maturation of O2 sensing and signaling in the chicken ductus arteriosus

2009 ◽  
Vol 297 (4) ◽  
pp. L619-L630 ◽  
Author(s):  
Angel L. Cogolludo ◽  
Javier Moral-Sanz ◽  
Saskia van der Sterren ◽  
Giovanna Frazziano ◽  
Anne N. H. van Cleef ◽  
...  
Keyword(s):  
Kinase Inhibitors ◽  
Channel Blocker ◽  
Ductus Arteriosus ◽  
Rho Kinase ◽  
High Amplitude ◽  
Common Mechanism ◽  
Rho Kinase Inhibitors ◽  
Transport Chain ◽  
O2 Sensing

The increase in O2 tension after birth is a major factor stimulating ductus arteriosus (DA) constriction and closure. Here we studied the role of the mitochondrial electron transport chain (ETC) as sensor, H2O2 as mediator, and voltage-gated potassium (KV) channels and Rho kinase as effectors of O2-induced contraction in the chicken DA during fetal development. Switching from 0% to 21% O2 contracted the pulmonary side of the mature DA (mature pDA) but had no effect in immature pDA and relaxed the aortic side of the mature DA (mature aDA). This contraction of the pDA was attenuated by inhibitors of the mitochondrial ETC and by the H2O2 scavenger polyethylene glycol (PEG)-catalase. Moreover, O2 increased reactive oxygen species (ROS) production, measured with the fluorescent probes dihydroethidium and 2′,7′-dichlorofluorescein, only in mature pDA. The H2O2 analog t-butyl-hydroperoxide mimicked the responses to O2 in the three vessels. In contrast to immature pDA cells, mature pDA cells exhibited high-amplitude O2-sensitive potassium currents. The KV channel blocker 4-aminopyridine prevented the current inhibition elicited by O2. The L-type Ca2+ (CaL) channel blocker nifedipine and the Rho kinase inhibitors Y-27632 and hydroxyfasudil induced a similar relaxation when mature pDA were stimulated with O2 or H2O2. Moreover, the sensitivity to these drugs increased with maturation. Our results indicate the presence of a common mechanism for O2 sensing/signaling in mammalian and nonmammalian DA and favor the idea that, rather than a single mechanism, a parallel maturation of the sensor and effectors is critical for O2 sensitivity appearance during development.

scholarly journals Biomechanical studies of the iris and the trabecular meshwork

2015 ◽  
Vol 8 (1) ◽  
pp. 69-78
Author(s):  
Sergey Yur'yevich Petrov ◽  
Nataliya Nikolaevna Podgornaya ◽  
Anna Eduardovna Aslamazova ◽  
Dar'ya Maksimovna Safonova
Keyword(s):  
Trabecular Meshwork ◽  
Kinase Inhibitors ◽  
Rho Kinase ◽  
Biomechanical Properties ◽  
Angle Closure ◽  
Anatomical Structures ◽  
New Class ◽  
Rho Kinase Inhibitors ◽  
Ocular Biomechanics

The article presents a literature review of the latest research in the field of ocular biomechanics with an accent on the role of biomechanical properties of anatomical structures in the development of ocular pathologies. Close attention is paid to biomechanical properties of the iris, the study of its structure and functioning in representatives of different races, as well as its role in anterior eye chamber angle closure and the pathogenesis of angle-closure glaucoma. Experimental and clinical researches of trabecular meshwork biomechanics and modern outlooks on its structure characteristics are described. The review provides information on theoretical developments and practical implications of the development of a new class of local hypotensive drugs that influence the trabecular meshwork tonus (Rho-kinase inhibitors).

Probing Cellular Outcomes Using Heterobivalent Constructs

2019 ◽  
Author(s):  
Rohit Bhadoria ◽  
Kefeng Ping ◽  
Christer Lohk ◽  
Ivar Järving ◽  
Pavel Starkov
Keyword(s):  
Cell Viability ◽  
Small Molecules ◽  
Cellular Uptake ◽  
Kinase Inhibitors ◽  
Rho Kinase ◽  
Intracellular Delivery ◽  
Rho Kinase Inhibitors

<div> <div> <div> <p>Conjugation techniques are central to improving intracellular delivery of bioactive small molecules. However, tracking and assessing the overall biological outcome of these constructs remains poorly understood. We addressed this issue by having developed a focused library of heterobivalent constructs based on Rho kinase inhibitors to probe various scenarios. By comparing induction of a phenotype of interest vs. cell viability vs. cellular uptake, we demonstrate that such conjugates indeed lead to divergent cellular outcomes. </p> </div> </div> </div>

scholarly journals Neovascular Macular Degeneration: A Review of Etiology, Risk Factors, and Recent Advances in Research and Therapy

2021 ◽  
Vol 22 (3) ◽  
pp. 1170
Author(s):  
Arunbalaji Pugazhendhi ◽  
Margaret Hubbell ◽  
Pooja Jairam ◽  
Balamurali Ambati
Keyword(s):  
Risk Factors ◽  
Macular Degeneration ◽  
Kinase Inhibitors ◽  
Rho Kinase ◽  
The Elderly ◽  
Age Related Macular Degeneration ◽  
Gene Therapies ◽  
Rho Kinase Inhibitors ◽  
Age Related ◽  
Endothelial Growth Factor

Neovascular age-related macular degeneration (exudative or wet AMD) is a prevalent, progressive retinal degenerative macular disease that is characterized by neovascularization of the choroid, mainly affecting the elderly population causing gradual vision impairment. Risk factors such as age, race, genetics, iris color, smoking, drinking, BMI, and diet all play a part in nvAMD’s progression, with anti-vascular endothelial growth factor (anti-VEGF) therapy being the mainstay of treatment. Current therapeutic advancements slow the progression of the disease but do not cure or reverse its course. Newer therapies such as gene therapies, Rho-kinase inhibitors, and levodopa offer potential new targets for treatment.

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