Corrigendum to “The novel peripherally active cannabinoid type 1 and serotonin type 3 receptor agonist AM9405 inhibits gastrointestinal motility and reduces abdominal pain in mouse models mimicking irritable bowel syndrome” [Eur. J. Pharmacol. (2018), 836 34–43]

2019 ◽  
Vol 862 ◽  
pp. 172656
Author(s):  
Maciej Salaga ◽  
Agata Binienda ◽  
Ritesh B. Tichkule ◽  
Ganesh A. Thakur ◽  
Alexandros Makriyannis ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Abdominal Pain ◽  
Mouse Models ◽  
Gastrointestinal Motility ◽  
Receptor Agonist ◽  
The Novel ◽  
Irritable Bowel ◽  
Type 3

Cytokine changes in colonic mucosa associated withBlastocystisspp. subtypes 1 and 3 in diarrhoea-predominant irritable bowel syndrome

Parasitology ◽  
2014 ◽  
Vol 141 (7) ◽  
pp. 957-969 ◽  
Author(s):  
JAVED YAKOOB ◽  
ZAIGHAM ABBAS ◽  
MUHAMMAD WAQAS USMAN ◽  
AISHA SULTANA ◽  
MUHAMMAD ISLAM ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Mononuclear Cells ◽  
Rectal Mucosa ◽  
Mean Value ◽  
Proinflammatory Response ◽  
Peripheral Blood Mononuclear ◽  
Irritable Bowel ◽  
Type 3 ◽  
And Control

SUMMARYWe determined cytokines (e.g. interleukin-8, 10, 12 and TNF-α) expression by peripheral blood mononuclear cells (PBMCs) and in rectal mucosa in diarrhoea-predominant irritable bowel syndrome (D-IBS) withBlastocystisspp. Eighty patients with D-IBS andBlastocystisspp. infection were classified as ‘cases’ and 80 with D-IBS withoutBlastocystisspp. infection were classified as ‘control’. Cases were subdivided into D-IBS andBlastocystissp. defined type 1 (subtype-specific primer SB83) and type 3 (SB227). Stool microscopy and culture were performed. Rectal biopsies were obtained for histology and cytokines by real-time PCR for mRNA expression of cytokines. PBMCs IL-8 was similar in different groups but in type 1, IL-8mRNA was increased compared with type 3 (P = 0·001) and control (P = 0·001). In type 1, IL-10 by PBMCs had a low mean value (14·5±1·6) compared with (16·7±1·5) type 3 and (16±2·3) in controls (P<0·001 andP<0·001, respectively). InBlastocystissp. type 1, low IL-10 was associated with lymphocyte and plasma cell infiltration (P = 0·015 andP = 0·002, respectively). InBlastocystissp. type 1 and type 3, IL-12 was associated with goblet cell depletion 23 (85%) (P<0·001) and 8 (29%) (P = 0·037), respectively. InBlastocystissp. type 1, low IL-10 was associated with a proinflammatory response characterized by IL-8.

Effectiveness of rifaximin in the treatment of abdominal pain at irritable bowel syndrome

2020 ◽  
Vol 0 (4) ◽  
pp. 22-28
Author(s):  
S. M. Tkach ◽  
A. E. Dorofeev ◽  
N. M. Mirzabaeva
Keyword(s):  
Irritable Bowel Syndrome ◽  
Abdominal Pain ◽  
Irritable Bowel
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