Early identification of epileptic encephalopathy with continuous spikes-and-waves during sleep: A case-control study

Background: Newborns with Hypoxic Ischemic Encephalopathy (HIE) are at risk of neuro-developmental disabilities. Early identification of their neuro-developmental impairments (NDI), immediate intervention and reassessment might be a useful method to measure and prevent major disability. This study was performed to identify impairment in different developmental domains among the babies admitted with moderate to severe degree HIE, and evaluate their outcomes after intervention with developmental therapy and stimulation.Methodology: The exploratory case control study was conducted during April 2008 till February 2012. We enrolled 81 full-term babies admitted to the special care neonate unite with HIE as case. The control group included age and sex matched 81 babies who did not have HIE. Neurodevelopmental assessment was performed using age specific rapid neurodevelopmental assessment tool (RNDA) by trained developmental therapists (DT). Intervention with developmental therapy and stimulation was provided for every child. Those who had assessment at least twice, (at entry and after 1 year age) were included for this study.Results: Male were predominating (66.7%). Mean age was 18 and 19 days on the 1st ; 17 and18 months on last assessment day in case and control group respectively. NDI was identified in 89% and 35% in case and control group respectively. On last assessment, 42% developed disability (permanent functional deficit), 35.8% achieved age appropriate developmental skills, 20% were lost to follow up, and 2 children died among the case group. These were 16% (13/81), 72% and 12% respectively among the control group. Significant correlation was found between the 1st and last assessment result among the case and control group.Conclusion: Early identification of NDI using a valid assessment tool and immediate intervention could probably reduce the disability in babies with HIE. A long time evaluation of this cohort would provide valuable information.Bangladesh J Child Health 2015; VOL 39 (1) :6-13

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Des-Gamma-Carboxyprothrombin for Early Identification and Prognosis of Hepatocellular Carcinoma - A Case Control Study from Western Nepal

Asian Pacific Journal of Cancer Prevention ◽

10.7314/apjcp.2012.13.11.5773 ◽

2012 ◽

Vol 13 (11) ◽

pp. 5773-5775 ◽

Cited By ~ 4

Author(s):

Ankush Mittal ◽

Satrudhan Pd Gupta ◽

Brijesh Sathian ◽

Jayadevan Sreedharan ◽

Bibek Poudel ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Early Identification ◽

Case Control Study ◽

Case Control ◽

Control Study

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Combination of inflammatory and vascular markers in the febrile phase of dengue is associated with more severe outcomes

eLife ◽

10.7554/elife.67460 ◽

2021 ◽

Vol 10 ◽

Author(s):

Nguyen Lam Vuong ◽

Phung Khanh Lam ◽

Damien Keng Yen Ming ◽

Huynh Thi Le Duyen ◽

Nguyet Minh Nguyen ◽

...

Keyword(s):

Early Identification ◽

Patient Management ◽

Case Control Study ◽

Case Control ◽

Severe Dengue ◽

Clinical Use ◽

Country Study ◽

Vascular Markers ◽

Nested Case Control ◽

Control Study

Background: Early identification of severe dengue patients is important regarding patient management and resource allocation. We investigated the association of ten biomarkers (VCAM-1, SDC-1, Ang-2, IL-8, IP-10, IL-1RA, sCD163, sTREM-1, ferritin, CRP) with the development of severe/moderate dengue (S/MD). Methods: We performed a nested case-control study from a multi-country study. A total of 281 S/MD and 556 uncomplicated dengue cases were included. Results: On days 1-3 from symptom onset, higher levels of any biomarker increased the risk of developing S/MD. When assessing together, SDC-1 and IL-1RA were stable, while IP-10 changed the association from positive to negative; others showed weaker associations. The best combinations associated with S/MD comprised IL-1RA, Ang-2, IL-8, ferritin, IP-10, and SDC-1 for children, and SDC-1, IL-8, ferritin, sTREM-1, IL-1RA, IP-10, and sCD163 for adults. Conclusions: Our findings assist the development of biomarker panels for clinical use and could improve triage and risk prediction in dengue patients.

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Combination of inflammatory and vascular markers in the febrile phase of dengue is associated with more severe outcomes

10.1101/2021.03.13.21253501 ◽

2021 ◽

Author(s):

Nguyen Lam Vuong ◽

Phung Khanh Lam ◽

Damien Keng Yen Ming ◽

Huynh Thi Le Duyen ◽

Nguyet Minh Nguyen ◽

...

Keyword(s):

Early Identification ◽

Patient Management ◽

Case Control Study ◽

Case Control ◽

Severe Dengue ◽

Clinical Use ◽

Country Study ◽

Vascular Markers ◽

Nested Case Control ◽

Control Study

AbstractBackgroundEarly identification of severe dengue patients is important regarding patient management and resource allocation. We investigated the association of ten biomarkers (VCAM-1, SDC-1, Ang-2, IL-8, IP-10, IL-1RA, sCD163, sTREM-1, ferritin, CRP) with the development of severe/moderate dengue (S/MD).MethodsWe performed a nested case-control study from a multi-country study. A total of 281 S/MD and 556 uncomplicated dengue cases were included.ResultsOn days 1-3 from symptom onset, higher levels of any biomarker increased the risk of developing S/MD. When assessing together, SDC-1 and IL-1RA were stable, while IP-10 changed the association from positive to negative; others showed weaker associations. The best combinations associated with S/MD comprised IL-1RA, Ang-2, IL-8, ferritin, IP-10, and SDC-1 for children, and SDC-1, IL-8, ferritin, sTREM-1, IL-1RA, IP-10, and sCD163 for adults.ConclusionsOur findings assist the development of biomarker panels for clinical use and could improve triage and risk prediction in dengue patients.Summary of the main pointHigher levels of any of VCAM-1, SDC-1, Ang-2, IL-8, IP-10, IL-1RA, sCD163, sTREM-1, ferritin, and CRP on illness days 1-3 increased the risk of developing severe/moderate dengue. The relationships differed between children and adults and some changed when assessed together.

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