Ethylene vinyl acetate (EVA) as a new drug carrier for 3D printed medical drug delivery devices

2016 ◽  
Vol 90 ◽  
pp. 53-63 ◽  
Author(s):  
Natalja Genina ◽  
Jenny Holländer ◽  
Harri Jukarainen ◽  
Ermei Mäkilä ◽  
Jarno Salonen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Vinyl Acetate ◽  
Drug Carrier ◽  
Ethylene Vinyl Acetate ◽  
New Drug ◽  
3D Printed ◽  
Drug Delivery Devices ◽  
Medical Drug

Anti-VEGFR2 Antibody-modified Micelle for Triggered Drug Delivery and Effective Therapy of Choroidal Neovascularization

2019 ◽  
Vol 16 (3) ◽  
pp. 258-265
Author(s):  
Kei Takahashi ◽  
Tomomi Masuda ◽  
Mitsunori Harada ◽  
Tadashi Inoue ◽  
Shinsuke Nakamura ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Choroidal Neovascularization ◽  
Pigment Epithelium ◽  
Drug Carrier ◽  
Retinal Pigment ◽  
Laser Coagulation ◽  
Antiangiogenic Agents ◽  
Drug Carrier System ◽  
Novel Drug ◽  
Drug Delivery Devices

Objective: This study aimed to examine whether DC101 (anti-VEGFR2 antibody)- modified micelles have applications as novel drug delivery devices, which allow small molecule antiangiogenic agents to deliver to angiogenic sites on a murine laser-induced choroidal neovascularization (CNV) model. Materials and Method: CNV was induced by photocoagulation on the unilateral eye of each mouse under anesthesia. Immediately after laser coagulation, E7974-loaded DC101-modified micelles and motesanib-loaded DC101-modified micelles were intravitreally administrated. Two weeks after photocoagulation, CNV was visualized using fluorescein-conjugated dextran (MW=2,000 kDa), and the CNV area was measured in retinal pigment epithelium (RPE)-choroidal flat mounts. Results: Intravitreal administration of both DC101-modified micelles loaded with E7974 at 2 µM and motesanib at 2 µM significantly reduced CNV area in the murine laser-induced CNV model at a clearly lower concentration than the effective dose of each agent. Conclusion: These results suggest that DC101-modified micelle might be effective drug carrier system for treating CNV and other ocular angiogenic diseases.

scholarly journals Non-Ionic Surfactant Vesicles (Niosomes) as New Drug Delivery Systems

2017 ◽  
pp. 154-184
Author(s):  
Abbas Pardakhty
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Drug Carrier ◽  
Lipid Vesicles ◽  
Ionic Surfactant ◽  
Not Given ◽  
Routes Of Administration ◽  
New Drug ◽  
Surfactant Vesicles ◽  
Drug Carrier System

Lipid vesicular systems composed of hydrated amphihiles with or without bilayer inducing agents such as cholesterol. On the basis of used amphiphilic molecule different nomenclature are used as liposomes, ufasomes and niosomes. Nonionic surfactants with mono-, di- or trialkyl chains form niosomes which are lipid vesicles with more chemical stability in comparison with phospholipids of liposomes. Both hydrophobic and hydrophilic chemicals can be encapsulated in niosomes as a new drug delivery system. This drug carrier system could have administered via injection, oral, pulmonary, vaginal, rectal, ophthalmic, nasal or transdermal routes with penetration enhancing potential. This chapter presents a detailed explain about niosome forming components, methods of preparation and routes of administration. Many examples for drug delivery potential of niosomes are also available in this review. Vaccine adjuvant and genetic substances vector capabilities are not given here.

Non-Ionic Surfactant Vesicles (Niosomes) as New Drug Delivery Systems

2017 ◽  
pp. 89-119 ◽  
Author(s):  
Abbas Pardakhty
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Drug Carrier ◽  
Lipid Vesicles ◽  
Ionic Surfactant ◽  
Not Given ◽  
Routes Of Administration ◽  
New Drug ◽  
Surfactant Vesicles ◽  
Drug Carrier System

Lipid vesicular systems composed of hydrated amphihiles with or without bilayer inducing agents such as cholesterol. On the basis of used amphiphilic molecule different nomenclature are used as liposomes, ufasomes and niosomes. Nonionic surfactants with mono-, di- or trialkyl chains form niosomes which are lipid vesicles with more chemical stability in comparison with phospholipids of liposomes. Both hydrophobic and hydrophilic chemicals can be encapsulated in niosomes as a new drug delivery system. This drug carrier system could have administered via injection, oral, pulmonary, vaginal, rectal, ophthalmic, nasal or transdermal routes with penetration enhancing potential. This chapter presents a detailed explain about niosome forming components, methods of preparation and routes of administration. Many examples for drug delivery potential of niosomes are also available in this review. Vaccine adjuvant and genetic substances vector capabilities are not given here.

3D printed drug delivery devices: perspectives and technical challenges

2017 ◽  
Vol 14 (9) ◽  
pp. 685-696 ◽  
Author(s):  
Mirja Palo ◽  
Jenny Holländer ◽  
Jaakko Suominen ◽  
Jouko Yliruusi ◽  
Niklas Sandler
Keyword(s):  
Drug Delivery ◽  
3D Printed ◽  
Technical Challenges ◽  
Drug Delivery Devices

Drug Carrier Systems Based on Cyclodextrin Supramolecular Assemblies and Polymers: Present and Perspectives

2017 ◽  
Vol 23 (3) ◽  
pp. 411-432 ◽  
Author(s):  
Gustavo Gonzalez-Gaitano ◽  
Jose Ramon Isasi ◽  
Itziar Velaz ◽  
Arantza Zornoza
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Drug Carrier ◽  
Drug Carriers ◽  
Pharmaceutical Applications ◽  
Recent Developments ◽  
Covalently Linked ◽  
Drug Delivery Devices ◽  
Carrier Systems ◽  
Drug Carrier Systems

The pharmaceutical applications of cyclodextrins (CDs), cyclic oligosaccharides capable of including hydrophobic molecules inside their cavities, have been known for decades. Besides the solubilising and encapsulating abilities of natural and modified CDs due to the formation of inclusion complexes, there is an increasing interest in organized macrostructures based on CDs as potential drug delivery devices and gene carrier systems. The present review discusses first the case of drug carriers based on monomeric modified CDs (amphiphilic and CD core-star polymers), in which self-assembly plays a major role. Polyrotaxanes, i.e., CDs threaded onto a polymer chain, are then reviewed in relation to their pharmaceutical applications. Finally, covalently linked CDs, either by grafting or crosslinking, are analyzed, including more complex structures formed by assembling CDcontaining networks or chains. We have tried along this review to cover the most recent developments on these structures for drug delivery in a “beyond the cyclodextrin” approach. The review will be helpful, both for readers who want to be introduced into the world of these remarkable structures, or for specialists who are doing research in this field.

Progress on Chitosan Nanoparticles as Drug Delivery Carriers

2013 ◽  
Vol 684 ◽  
pp. 53-56 ◽  
Author(s):  
Zhi Hua Xing
Keyword(s):  
Drug Delivery ◽  
Drug Carrier ◽  
Chitosan Nanoparticles ◽  
Development Prospect ◽  
Dna Transfection ◽  
New Drug ◽  
Organ Targeting

To review the progress on chitosan nanoparticles as drug delivery carriers, the application of chitosan nanoparticles in the fields of organ targeting, DNA transfection, and non-injection administration are summarized according to recent references. The results showed that chitosan nanoparticles as a new drug carrier have important value of research and extensively development prospect.

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