Corrigendum to ‘A proposed pediatric biopharmaceutical classification system for medications for chronic diseases in children’ [European Journal of Pharmaceutical Sciences 152 (2020) 105437]

Polyphenols are natural organic compounds produced by plants, acting as antioxidants by reacting with ROS. These compounds are widely consumed in daily diet and many studies report several benefits to human health thanks to their bioavailability in humans. However, the digestion process of phenolic compounds is still not completely clear. Moreover, bioavailability is dependent on the metabolic phase of these compounds. The LogP value can be managed as a simplified measure of the lipophilicity of a substance ingested within the human body, which affects resultant absorption. The biopharmaceutical classification system (BCS), a method used to classify drugs intended for gastrointestinal absorption, correlates the solubility and permeability of the drug with both the rate and extent of oral absorption. BCS may be helpful to measure the bioactive constituents of foods, such as polyphenols, in order to understand their nutraceutical potential. There are many literature studies that focus on permeability, absorption, and bioavailability of polyphenols and their resultant metabolic byproducts, but there is still confusion about their respective LogP values and BCS classification. This review will provide an overview of the information regarding 10 dietarypolyphenols (ferulic acid, chlorogenic acid, rutin, quercetin, apigenin, cirsimaritin, daidzein, resveratrol, ellagic acid, and curcumin) and their association with the BCS classification.

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Identifying Environmental Determinants Relevant to Health and Wellbeing in Remote Australian Indigenous Communities: A Scoping Review of Grey Literature

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18084167 ◽

2021 ◽

Vol 18 (8) ◽

pp. 4167

Author(s):

Amal Chakraborty ◽

Mark Daniel ◽

Natasha J. Howard ◽

Alwin Chong ◽

Nicola Slavin ◽

...

Keyword(s):

Public Health ◽

Chronic Diseases ◽

Scoping Review ◽

Classification System ◽

Grey Literature ◽

Indigenous Communities ◽

Environmental Indicators ◽

Health Concern ◽

Environmental Determinants ◽

Health And Wellbeing

The high prevalence of preventable infectious and chronic diseases in Australian Indigenous populations is a major public health concern. Existing research has rarely examined the role of built and socio-political environmental factors relating to remote Indigenous health and wellbeing. This research identified built and socio-political environmental indicators from publicly available grey literature documents locally-relevant to remote Indigenous communities in the Northern Territory (NT), Australia. Existing planning documents with evidence of community input were used to reduce the response burden on Indigenous communities. A scoping review of community-focused planning documents resulted in the identification of 1120 built and 2215 socio-political environmental indicators. Indicators were systematically classified using an Indigenous indicator classification system (IICS). Applying the IICS yielded indicators prominently featuring the “community infrastructure” domain within the built environment, and the “community capacity” domain within the socio-political environment. This research demonstrates the utility of utilizing existing planning documents and a culturally appropriate systematic classification system to consolidate environmental determinants that influence health and disease occurrence. The findings also support understanding of which features of community-level built and socio-political environments amenable to public health and social policy actions might be targeted to help reduce the prevalence of infectious and chronic diseases in Indigenous communities.

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Investigation of biopharmaceutical drug properties suitable for orally disintegrating tablets

ADMET & DMPK ◽

10.5599/admet.4.4.338 ◽

2016 ◽

Vol 4 (4) ◽

pp. 335 ◽

Cited By ~ 9

Author(s):

Asami Ono ◽

Takumi Tomono ◽

Takuo Ogihara ◽

Katsuhide Terada ◽

Kiyohiko Sugano

Keyword(s):

Classification System ◽

Immediate Release ◽

Basic Drugs ◽

Font Size ◽

Net Charge ◽

Solubility In Water ◽

Orally Disintegrating Tablets ◽

Significant Difference ◽

Dose Number ◽

Biopharmaceutical Classification System

<span style="color: black; font-family: 'Calibri','sans-serif'; font-size: 10pt; mso-fareast-font-family: 'Times New Roman'; mso-bidi-font-family: 'Times New Roman'; mso-ansi-language: EN-GB; mso-fareast-language: DE; mso-bidi-language: AR-SA;" lang="EN-GB">The purpose of this study was to evaluate the biopharmaceutical drug properties suitable for orally disintegrating tablets (ODTs). The net charge at pH 7.4, log D6.5, the highest dose strength, solubility in water, dose number, and elimination t1/2 of 57 ODT drugs and 113 drugs of immediate-release (IR) formulations were compared. These drugs were classified according to the Biopharmaceutical Classification System (BCS). A lower dose strength and a longer elimination t1/2 have been observed as characteristic properties of ODTs. The proportion of basic drugs was higher in the ODTs than in the IR. A significant difference was not observed between the ODT and the IR formulation for log D6.5, solubility in water, and dose number. The distributions of the ODT and IR formulations among each BCS class were similar, suggesting that an ODT can be developed regardless of the BCS class of a drug.

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ChemInform Abstract: Polymeric Amorphous Solid Dispersions: A Review of Amorphization, Crystallization, Stabilization, Solid-State Characterization, and Aqueous Solubilization of Biopharmaceutical Classification System Class II Drugs

ChemInform ◽

10.1002/chin.201642262 ◽

2016 ◽

Vol 47 (42) ◽

Author(s):

Shrawan Baghel ◽

Helen Cathcart ◽

Niall J. O'Reilly

Keyword(s):

Solid State ◽

Classification System ◽

Solid Dispersions ◽

Amorphous Solid ◽

Class Ii ◽

Amorphous Solid Dispersions ◽

Biopharmaceutical Classification System ◽

Solid State Characterization

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USE OF THE BIOPHARMACEUTICAL CLASSIFICATION SYSTEM FOR THE OPTIMIZATION OF THE DRUG QUALITY CONTROL IN THE UKRAINIAN MARKET

Hygiene of populated places ◽

10.32402/hygiene2019.69.261 ◽

2019 ◽

Vol 2019 (69) ◽

pp. 261-269

Author(s):

Ya.Yu. Nikolaieva ◽

◽

N.V. Ostanina ◽

M.G. Levin ◽

◽

...

Keyword(s):

Quality Control ◽

Classification System ◽

Drug Quality ◽

Biopharmaceutical Classification System ◽

Drug Quality Control

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Formulation and evaluation of liquisolid compacts of itraconazole to enhance its oral bioavailability

Therapeutic Delivery ◽

10.4155/tde-2019-0050 ◽

2020 ◽

Vol 11 (2) ◽

pp. 83-96

Author(s):

Hetal P Thakkar ◽

Deepika Vasava ◽

Arpita A Patel ◽

Rahul D Dhande

Keyword(s):

Antifungal Activity ◽

Classification System ◽

Oral Bioavailability ◽

Room Temperature ◽

Coating Material ◽

Drug Dissolution ◽

Dry Powder ◽

Liquisolid Compacts ◽

Biopharmaceutical Classification System ◽

Peg 600

Aim: Formulate and evaluate liquisolid compacts of Itraconazole, a biopharmaceutical classification system class II drug, which has poor bioavailability. Materials & methods: PEG 600 was used as a nonvolatile solvent, Alfacel PH 200 as a carrier and Aerosil 200 as a coating material. The Itraconazole solution upon mixing with a carrier and coating material resulted in a dry powder, which was compressed into tablets. Results & conclusion: The optimized formulation exhibited a significantly higher drug dissolution (90.73% in 90 min) compared with conventional tablets and marketed capsules. The antifungal activity was retained in the formulation. Higher values of Cmax and AUC0-24 of the formulation compared with the plain drug indicated enhancement in oral bioavailability. The formulation was stable at room temperature as well as in accelerated conditions.

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