scholarly journals Clinical utility of urinary soluble CD163 in evaluation of lupus nephritis patients

2022 ◽  
Vol 44 (2) ◽  
pp. 151-157
Author(s):  
Nada M. Gamal ◽  
Eman R. Badawy ◽  
Esraa A Talaat ◽  
Hamdy M. Ibrahim ◽  
Mona H. Abd Elsamea
Keyword(s):  
Lupus Nephritis ◽  
Clinical Utility ◽  
Soluble Cd163

scholarly journals Urinary Soluble CD163: a Novel Noninvasive Biomarker of Activity for Lupus Nephritis

2020 ◽  
Vol 31 (6) ◽  
pp. 1335-1347 ◽  
Author(s):  
Juan M. Mejia-Vilet ◽  
Xiaolan L. Zhang ◽  
Cristino Cruz ◽  
Mayra L. Cano-Verduzco ◽  
John P. Shapiro ◽  
...  
Keyword(s):  
United States ◽  
Lupus Nephritis ◽  
Activity Index ◽  
Response To Therapy ◽  
Clinical Severity ◽  
Renal Response ◽  
Soluble Cd163 ◽  
Active Lupus Nephritis ◽  
Histologic Activity Index ◽  
Active Lupus

BackgroundClinical distinction between patients with lupus nephritis who have active inflammation or chronic kidney damage is challenging. Studies have shown soluble CD163, which derives from cleavage of the CD163 M2c macrophage receptor and can be quantified in urine, correlates with active lupus nephritis.MethodsWe measured urine CD163 at lupus nephritis flares in patients from a Mexican cohort and cross-sectional and longitudinal United States cohorts. We also performed serial urine CD163 measurements during the treatment of flares in a subset of patients from the Mexican and longitudinal United States cohorts, and assessed response to therapy at 12 months. In addition, we evaluated urinary CD163 agreement with histologic activity in 19 patients from the Mexican cohort who had repeated kidney biopsies on follow-up.ResultsUrinary CD163 levels were significantly higher in patients with active lupus nephritis than in patients with active extrarenal SLE, inactive SLE, and other glomerular diseases, and correlated with disease clinical severity, histologic class, and the histologic activity index. Urinary CD163 increased from 6 months preflare to flare, diminishing progressively in complete and partial responders, whereas it remained elevated in nonresponders. Urinary CD163 <370 ng/mmol at 6 months predicted complete renal response at 12 months with >87% sensitivity and >87% specificity. Urinary CD163 <370 ng/mmol or >370 ng/mmol perfectly agreed (κ=1.0) with a histologic activity index ≤1 or >1 in repeated biopsies, respectively. Evaluation of urinary CD163 in patients with persistent proteinuria at 6 months improved the prediction of who would achieve complete renal response at 12 months.ConclusionsUrinary CD163 reflects histologic inflammation in lupus nephritis and is a promising activity biomarker that varies over time with lupus nephritis activity and treatment.

scholarly journals MicroRNAs in Lupus Nephritis–Role in Disease Pathogenesis and Clinical Applications

2021 ◽  
Vol 22 (19) ◽  
pp. 10737
Author(s):  
Benjamin Y. F. So ◽  
Desmond Y. H. Yap ◽  
Tak Mao Chan
Keyword(s):  
Lupus Nephritis ◽  
Immune Cells ◽  
Small Rnas ◽  
Clinical Utility ◽  
Clinical Applications ◽  
Renal Cells ◽  
Kidney Fibrosis ◽  
Protein Levels ◽  
Genetic Sequences

MicroRNAs (miRs) are non-coding small RNAs that act as epigenetic modulators to regulate the protein levels of target mRNAs without modifying the genetic sequences. The role of miRs in the pathogenesis of lupus nephritis (LN) is increasingly recognized and highly complex. Altered levels of different miRs are observed in the blood, urine and kidney tissues of murine LN models and LN patients. Accumulating evidence suggests that these miRs can modulate immune cells and various key inflammatory pathways, and their perturbations contribute to the aberrant immune response in LN. The dysregulation of miRs in different resident renal cells and urinary exosomes can also lead to abnormal renal cell proliferation, inflammation and kidney fibrosis in LN. While miRs may hold promise in various clinical applications in LN patients, there are still many potential limitations and safety concerns for their use. Further studies are worthwhile to examine the clinical utility of miRs in the diagnosis, disease activity monitoring, prognostication and treatment of LN.

scholarly journals Urinary soluble CD163 level reflects glomerular inflammation in human lupus nephritis

2016 ◽  
Vol 31 (12) ◽  
pp. 2023-2033 ◽  
Author(s):  
Nobuhide Endo ◽  
Naotake Tsuboi ◽  
Kazuhiro Furuhashi ◽  
Yiqin Shi ◽  
Qiuna Du ◽  
...  
Keyword(s):  
Lupus Nephritis ◽  
Soluble Cd163

Type V Bekesy Pattern: Interpretation and Clinical Utility

1967 ◽  
Vol 10 (4) ◽  
pp. 733-744 ◽  
Author(s):  
William F. Rintelmann ◽  
Earl R. Harford
Keyword(s):  
Clinical Utility ◽  
The Past ◽  
Type V ◽  
Clinical Cases

Recent studies indicate there is some disagreement concerning the interpretation and clinical utility of the Type V Bekesy pattern. Bekesy tracings obtained over the past six years from a sample of clinical cases were analyzed and a definition was established for the Type V pattern. This definition was applied to Bekesy tracings obtained from normal listeners, hypoacusics, and pseudohypoacusics. The Type V pattern was found frequently among pseudohypoacusics and only rarely among other individuals.

“I Can See What You’re Saying”: Clinical Utility of Spectral Moment Analysis

2011 ◽  
Vol 21 (2) ◽  
pp. 44-54
Author(s):  
Kerry Callahan Mandulak
Keyword(s):  
Speech Production ◽  
Speech Signal ◽  
Clinical Utility ◽  
Acoustic Analysis ◽  
Moment Analysis ◽  
Analysis Tool ◽  
Spectral Moment ◽  
Clinical Measure ◽  
Perceptual Analysis ◽  
Disordered Speech

Spectral moment analysis (SMA) is an acoustic analysis tool that shows promise for enhancing our understanding of normal and disordered speech production. It can augment auditory-perceptual analysis used to investigate differences across speakers and groups and can provide unique information regarding specific aspects of the speech signal. The purpose of this paper is to illustrate the utility of SMA as a clinical measure for both clinical speech production assessment and research applications documenting speech outcome measurements. Although acoustic analysis has become more readily available and accessible, clinicians need training with, and exposure to, acoustic analysis methods in order to integrate them into traditional methods used to assess speech production.

Lupus nephritis in a neuronal storage disease

1977 ◽  
Vol 137 (5) ◽  
pp. 693-694 ◽  
Author(s):  
D. A. Feinfeld
Keyword(s):  
Lupus Nephritis ◽  
Storage Disease ◽  
Neuronal Storage Disease
Sign in / Sign up

Export Citation Format

Share Document