Contribution of regional 3D meniscus and cartilage morphometry by MRI to joint space width in fixed flexion knee radiography—A between-knee comparison in subjects with unilateral joint space narrowing

2013 ◽  
Vol 82 (12) ◽  
pp. e832-e839 ◽  
Author(s):  
K. Bloecker ◽  
W. Wirth ◽  
D.J. Hunter ◽  
J. Duryea ◽  
A. Guermazi ◽  
...  
Keyword(s):  
Joint Space Narrowing ◽  
Joint Space Width ◽  
Joint Space ◽  
Space Width ◽  
And Cartilage

scholarly journals Changes in Knee Joint Space Width in Treatment with a New Hyaluronic-Based Hydrogel

2017 ◽  
Vol 63 (3) ◽  
pp. 125-128
Author(s):  
Octav Marius Russu ◽  
Andrei Marian Feier ◽  
Tudor Sorin Pop ◽  
Marcela Todoran ◽  
István Gergely
Keyword(s):  
Hyaluronic Acid ◽  
Knee Joint ◽  
Knee Osteoarthritis ◽  
Joint Space Narrowing ◽  
Joint Space Width ◽  
Joint Space ◽  
One Year ◽  
A Minor ◽  
Space Width

AbstractObjective: Our purpose was to assess the effect of a new hyaluronic acid-based (Hymovis®) injections on joint space width narrowing in patients diagnosed with knee osteoarthritis.Methods: A prospective clinical trial was conducted in the Department of Orthopedics and Traumatology II from the Clinical County Hospital, Tîrgu Mureș, Romania. Thirty-five patients diagnosed with idiopathic knee osteoarthritis received two intraarticular injections with hyaluronic acid-based hydrogel (24 mg of hyaluronic acid/3 ml) at one-week interval. Anteroposterior radiographs were obtained before the injections, at six and twelve months after. Minimum joint space width was measured by two senior orthopaedics surgeons at each follow up. Each radiograph was measured again by the same evaluators two weeks apart.Results: Thirty-one patients were present at the final follow-up. A minor reduction in mean weight was noticed (from 82.2 kg ± 16.2 kg to 80.9 kg ± 16.0, p > 0.398) without any correlation with joint space width narrowing. There were no major changes at the first follow up (6 months) regarding joint space narrowing. A reduction in joint space width was observed however at 12 months varying from 4.4 mm (SD ± 1.64, range 1.8-7.1) at the first assessment to 4.3 mm (SD ± 1.26, range 0.0-6.8) at the final follow-up but with no statistical difference (p=0.237).Conclusion: No significant modification in joint space width at the final follow-up secondarily proved that two injections of Hymovis® may slow down narrowing in the knee joint space over a one-year period.

scholarly journals One-year change in radiographic joint space width in patients with unilateral joint space narrowing: Data from the osteoarthritis initiative

2010 ◽  
Vol 62 (7) ◽  
pp. 924-931 ◽  
Author(s):  
O. D. Benichou ◽  
D. J. Hunter ◽  
D. R. Nelson ◽  
A. Guermazi ◽  
F. Eckstein ◽  
...  
Keyword(s):  
Joint Space Narrowing ◽  
Joint Space Width ◽  
Joint Space ◽  
Osteoarthritis Initiative ◽  
One Year ◽  
Space Width

scholarly journals Mesenchymal Stem Cells Derived from Synovium and Fat Pad are Able to Treat Induced Ankle Osteoarthritis in Rats?

2020 ◽  
Vol 5 (4) ◽  
pp. 2473011420S0001
Author(s):  
Soheil Ashkani-Esfahani ◽  
Bart Lubberts ◽  
Rohan Bhimani ◽  
Christopher W. DiGiovanni
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Joint Space Width ◽  
Joint Space ◽  
Population Viability ◽  
Cell Distribution ◽  
Fat Pad ◽  
Matrix Cell ◽  
Space Width ◽  
And Cartilage

Category: Ankle Arthritis; Ankle; Basic Sciences/Biologics Introduction/Purpose: Osteoarthritis (OA) is a chronic disease and a significant cause of joint pain, tenderness, and limitation of motion. At present, no specific treatment is available and mesenchymal stem cells (MSCs) have shown promising potentials in this regard. Herein, we aimed to evaluate the repairing potentials of stem cells derived from synovium and fat pad in treatment of OA in ankle joint. Methods: Twenty-eight male rats (220+-20 g, aged 10-12 weeks), were randomly divided into four groups (n=7): C1: non- treated, C2: Hyalgan treated, E1: Adipose-tissue derived stem cell treated, and E2: synovial-membrane based stem cell treated groups. Collagenase type II enzyme was injected into the left ankle; after eight weeks, OA was developed. Then, stem cells were injected and rats were followed for three months. Afterwards, rats were euthanized and specimens and radiological images were provided. P-value<=0.05 was set as statistically significant. Results: Compared to C1, E1 and E2 groups showed significantly better results in all pathological criteria including surface, matrix, cell distribution, cell population viability, subchondral bone, and cartilage mineralization as well as joint space width and osteophytes developed in the joint (p<=0.001). Similarly, compared to C2 group, E1 and E2 had better scores regarding surface, matrix, cell distribution, and cell population viability (p<0.05). E2 showed considerably higher scores compared to C2 regarding subchondral bone and cartilage mineralization (p<0.05). Joint space width was similar between C2 and E groups. Conclusion: Treatment of OA of ankle with MSCs, particularly synovial-membrane derived stem cells, not only prevented but also healed OA to some extent in comparison to Hyalgan and non-treatment groups.

AB0822 WHICH CLINICAL FACTORS INFLUENCE MINERALIZATION OF THE METACARPAL BONES AND FINGER JOINT SPACE WIDTH IN PSORIATIC ARTHRITIS?

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1714.1-1715
Author(s):  
A. Pfeil ◽  
M. Heinz ◽  
D. Renz ◽  
J. Böttcher ◽  
G. Wolf ◽  
...  
Keyword(s):  
Joint Space Narrowing ◽  
Disease Duration ◽  
Joint Space Width ◽  
Joint Space ◽  
Finger Joint ◽  
Z Score ◽  
Mineral Density ◽  
Metacarpal Bones ◽  
Computer Aided ◽  
Space Width

Background:Metacarpal bone mineral density as measured by digital x-ray radiogrammetry (DXR-BMD) and finger joint space width quantified by computer-aided joint space analysis presented computer based and observer independent parameters for the evaluation of radiographic damage of the hand skeleton.Objectives:The aim of this study was to quantify clinical parameter which potential influence periarticular mineralisation of the metacarpal bones and finger joint space width in Psoriatic Arthritis (PsA)-patients.Methods:The study includes 201 PsA-patients. All patients received a radiograph of the hand. Bone mineral density was measured by DXR (Pronosco X-Posure System™, Version 2.0; Sectra; Sweden) and finger joint space width of all finger joints were evaluated by computer-aided joint space analysis (CAJSA, Radiogrammetry Kit, Version 1.3.6; Sectra; Sweden). The Z-Score was used as an age- and gender-independent parameter for the quantification finger joint space narrowing.Results:Regarding gender, the DXR-BMD was significant reduced with -0.028 g/cm2in women. An equivalent significant result was evaluated for finger joint space width (Z-ScoreMCP -1.07, Z-ScorePIP -0.81 and Z-ScoreDIP -0.76). The DXR-BMD was significantly lowert (-0.011 g/cm2) between the disease duration < 2 years (0.545±0.076 g/cm2) and >10 years (0.509±0.070 g/cm2). The Z-Score showed no significant change regarding the disease duration. Inflammatory activity as measured by c-reactive protein presented no impact on DXR-BMD and the Z-Score of all finger joints. Additionally, the use of corticosteroids was associated with a reduced DXR-BMD (-0.037 g/cm2) and an absence of finger joint space narrowing.Conclusion:The study highlights that the demineralisation of the metacarpal bones was associated with female gender, disease duration and the use of corticosteroids. Whereas, the prior mentioned parameters had no influence on finger joint space width. Consequently, periarticular demineralisation and finger joint space narrowing presented two different and independent radiological signs in PsA.References:N/ADisclosure of Interests:Alexander Pfeil Grant/research support from: This study Investigator Initiated Study “Automatic assessment of joint space narrowing in rheumatoid arthritis based on the Post-hoc analysis” (number: IIS-2016-110818) is a part of the of the Investigator Initiated Study “The quantification of inflammatory related periarticular bone loss in certolizumab pegol treated patients with rheumatoid arthritis” (number: IIS-2014-101458) which is supported by UCB Pharma GmbH, Monheim, Germany., Marcus Heinz: None declared, Diane Renz: None declared, Joachim Böttcher: None declared, Gunter Wolf: None declared, Peter Oelzner: None declared

scholarly journals Predictors of cartilage degeneration in patients with subchondral insufficiency fracture of the femoral head: a retrospective study

2020 ◽  
Author(s):  
Tomohiro Shimizu ◽  
Sunichi Yokota ◽  
Yosuke Kimura ◽  
Tsuyoshi Asano ◽  
Hirokazu Shimizu ◽  
...  
Keyword(s):  
Femoral Head ◽  
Joint Space Narrowing ◽  
Insufficiency Fracture ◽  
Joint Space Width ◽  
Joint Space ◽  
Band Pattern ◽  
Bone Metabolic Markers ◽  
Metabolic Markers ◽  
Subchondral Insufficiency Fracture ◽  
Space Width

Abstract Background: There is evidence that the cause of primary osteoarthritis (OA) is related to the changes in subchondral bone; however, the influence of subchondral insufficiency fracture (SIF) of the femoral head on the degeneration of the hip joint and the prognostic factors related to joint degeneration remain unclear. The objectives of this study were: 1) to investigate the natural history of joint space width after the occurrence of SIF and 2) to investigate the associations between joint space narrowing and bone metabolic markers as well as magnetic resonance imaging (MRI) among the patients with SIF.Methods: Between January 2010 and December 2019, 238 patients in whom band pattern of the femoral head were observed on MRI visited our hospital. Among these patients, 44 hips in 41 patients were diagnosed with SIF and eligible for this retrospective study. We evaluated the joint space width (JSW) of the hip on the radiograph obtained at the first and last visits, length of the band lesion on MRI, bone mineral density by dual-energy x-ray absorptiometry, and bone metabolism markers. Similarly, the factors associated with the necessity of surgery and the progression of the narrowing of the joint space were evaluated.Results: Fifteen of the 44 hips required total hip arthroplasty (THA). A significant decrease was observed in the JSW from the first visit to the final follow-up. Changes in the JSW were associated with the length of band patterns, serum type 1 procollagen-N-propeptide (P1NP), and tartrate-resistant acid phosphatase 5b (TRACP-5b) during diagnosis. Additionally, bone metabolic markers tended to be associated with the length of the band pattern. Conclusions: SIF could cause joint space narrowing and hip OA. In addition to MRI findings as prognostic predictors of SIF, as previously described, bone metabolic markers were equally associated with changes in JSW, suggesting that these parameters could be useful in predicting the prognosis of SIF. Considering that bone metabolic markers trended to be associated with the length of band pattern, they might reflect the local severity.

SAT0557 A Clinical Study To Examine Thresholds of Joint Space Width and Joint Space Area for Identification of Knee Osteoarthritis

2016 ◽  
Vol 75 (Suppl 2) ◽  
pp. 871.1-871
Author(s):  
R. Ljuhar ◽  
S. Nehrer ◽  
B. Norman ◽  
D. Ljuhar ◽  
T. Haftner ◽  
...  
Keyword(s):  
Clinical Study ◽  
Knee Osteoarthritis ◽  
Joint Space Width ◽  
Joint Space ◽  
Space Width
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