Ratio of marked and excised sentinel lymph nodes and scintigraphic appearance time in melanoma patients with negative sentinel lymph node

Introduction: Multinucleated giant cells (MGC) are a rare finding when evaluating axillary sentinel lymph nodes. Some are described as foreign body-type MGC accompanied by foamy macrophages. They have been rarely reported in nodes from patients in which a previous breast biopsy was performed. The tissue damage induced by biopsy results in secondary changes including fat necrosis and hemorrhage that can migrate to axillary nodes. In this report, we illustrate a lipogranulomatous reaction in cytologic samples obtained during a sentinel lymph node examination of a woman previously biopsied because of breast carcinoma. We have found no previous cytologic descriptions and consider it an interesting finding that should be known to avoid diagnostic misinterpretations. Case: A 51-year-old woman underwent mastectomy of the right breast with a sentinel lymph node biopsy at our medical center. One month before, a control mammography revealed suspicious microcalcifications and a vacuum-assisted breast biopsy resulted in a diagnosis of high-grade intraductal carcinoma with comedonecrosis. Surgery with a sentinel lymph node biopsy was performed. The sentinel node was processed as an intraoperative consultation. Frozen sections and air-dried Diff-Quik stained samples were obtained. They showed abundant lymphocytes with MGC and tumoral cells. MGC showed ample cytoplasm with evident vacuoles of variable size. Occasional hemosiderin-laden macrophages were also present. The complete histologic analysis and immunohistochemical studies revealed no malignant cells. Histologic analysis showed, in subcapsular location, occasional MGC phagocyting lipid droplets. Hemosiderin-laden macrophages were a common finding. Conclusion: Lipogranulomas may appear at axillary sentinel lymph nodes because of fat necrosis induced by previous breast biopsy. The most important consideration is not confounding MGC with epithelial cell clusters. This can occur with not well-processed samples, especially if unmounted.

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84P Predictive factors for non-sentinel lymph node involvement in patients with breast cancer and 1-2 positive sentinel lymph nodes treated with breast conservation

Annals of Oncology ◽

10.1093/annonc/mdv519.33 ◽

2015 ◽

Vol 26 ◽

pp. ix16

Author(s):

Y. Tanaka ◽

T. Fujita ◽

Y. Sagara ◽

S. Nishida ◽

S. Shiba ◽

...

Keyword(s):

Breast Cancer ◽

Lymph Node ◽

Sentinel Lymph Node ◽

Lymph Nodes ◽

Predictive Factors ◽

Breast Conservation ◽

Lymph Node Involvement ◽

Sentinel Lymph Nodes ◽

Node Involvement

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Do axillary sentinel lymph node micrometastases predict involvement of the non-sentinel lymph nodes in breast cancer?

International Journal of Surgery ◽

10.1016/j.ijsu.2013.06.128 ◽

2013 ◽

Vol 11 (8) ◽

pp. 610

Author(s):

Ashley Topps ◽

Emma de Sousa ◽

Katherine McNamara ◽

Katherine Miller ◽

Mohammed Absar

Keyword(s):

Breast Cancer ◽

Lymph Node ◽

Sentinel Lymph Node ◽

Lymph Nodes ◽

Sentinel Lymph Nodes ◽

Lymph Node Micrometastases

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Identification of the sentinel lymph node using hemosiderin in locally advanced breast cancer

Revista do Colégio Brasileiro de Cirurgiões ◽

10.1590/0100-69912017006013 ◽

2017 ◽

Vol 44 (6) ◽

pp. 612-618

Author(s):

PAULO HENRIQUE WALTER DE AGUIAR ◽

RANNIERE GURGEL FURTADO DE AQUINO ◽

MAYARA MAIA ALVES ◽

JULIO MARCUS SOUSA CORREIA ◽

AYANE LAYNE DE SOUSA OLIVEIRA ◽

...

Keyword(s):

Breast Cancer ◽

Lymph Node ◽

Sentinel Lymph Node ◽

Lymph Nodes ◽

Advanced Breast Cancer ◽

Locally Advanced Breast Cancer ◽

Locally Advanced ◽

Sentinel Lymph Nodes ◽

Advanced Breast ◽

Identification Rate

ABSTRACT Objective: to verify the agreement rate in the identification of sentinel lymph node using an autologous marker rich in hemosiderin and 99 Technetium (Tc99) in patients with locally advanced breast cancer. Methods: clinical trial phase 1, prospective, non-randomized, of 18 patients with breast cancer and clinically negative axilla stages T2=4cm, T3 and T4. Patients were submitted to sub-areolar injection of hemosiderin 48 hours prior to sentinel biopsy surgery, and the identification rate was compared at intraoperative period to the gold standard marker Tc99. Agreement between methods was determined by Kappa index. Results: identification rate of sentinel lymph node was 88.9%, with a medium of two sentinel lymph nodes per patients. The study identified sentinel lymph nodes stained by hemosiderin in 83.3% patients (n=15), and, compared to Tc99 identification, the agreement rate was 94.4%. Conclusion: autologous marker rich in hemosiderin was effective to identify sentinel lymph nodes in locally advanced breast cancer patients.

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Novel quinoline-based near-infrared fluorescent bioimaging probe, KSNP117, for sentinel lymph node mapping

Journal of Materials Chemistry B ◽

10.1039/d1tb00568e ◽

2021 ◽

Author(s):

Ahmed A. Elbatrawy ◽

Da Sol Lee ◽

Sang Bong Lee ◽

Hui-Jeon Jeon ◽

Sijoon Lee ◽

...

Keyword(s):

Lymph Node ◽

Sentinel Lymph Node ◽

Lymph Nodes ◽

Near Infrared ◽

High Sensitivity ◽

Sentinel Lymph Node Mapping ◽

Sentinel Lymph Nodes ◽

Fluorescent Imaging ◽

Imaging Agents ◽

Lymph Node Mapping

Near-infrared (NIR) fluorescent imaging agents with biocompatibility and high sensitivity are urgently required for the accurate detection of sentinel lymph nodes (SLNs). Herein, we report the design of a novel...

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Clinical application of the sentinel lymph node technique in early ovarian cancer: a pilot study

International Journal of Gynecological Cancer ◽

10.1136/ijgc-2018-000049 ◽

2018 ◽

Vol 29 (2) ◽

pp. 377-381 ◽

Cited By ~ 11

Author(s):

V Lago ◽

P Bello ◽

B Montero ◽

L Matute ◽

P Padilla-Iserte ◽

...

Keyword(s):

Ovarian Cancer ◽

Lymph Node ◽

Pilot Study ◽

Sentinel Lymph Node ◽

Lymph Nodes ◽

Near Infrared ◽

Early Stage ◽

Gamma Probe ◽

Sentinel Lymph Nodes ◽

Near Infrared Fluorescence Imaging

IntroductionThere is limited evidence favoring the use of the sentinel lymph node technique in ovarian cancer, and no standardized approach has been studied. The objective of the present pilot study is to determine the feasibility of the sentinel lymph node technique by applying a clinical algorithm.MethodsPatients with confirmed ovarian cancer were included. 99mTc and indocyanine green were injected into the ovarian and infundubulo-pelvic ligament stump. A gamma probe and near-infrared fluorescence imaging were used for sentinel lymph node detection.ResultsThe sentinel lymph node technique was performed in ten patients with a detection rate in the pelvic and/or para-aortic region of 100%. The tracer distribution rates of sentinel lymph nodes in the pelvic and para-aortic regions were 87.5% and 70%, respectively.ConclusionThe detection of sentinel lymph nodes in early-stage ovarian cancer appears to be achievable. Based on these results, a clinical trial entitled SENTOV (SENtinel lymph node Technique in OVarian cancer) will be performed.

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