scholarly journals Renal Prognosis in Children with Tubulointerstitial Nephritis and Uveitis Syndrome

2021 ◽  
Author(s):  
Agnès Chevalier ◽  
Claire Duflos ◽  
Stephanie Clave ◽  
Olivia Boyer ◽  
Julien Hogan ◽  
...  
Keyword(s):  
Tubulointerstitial Nephritis ◽  
Renal Prognosis

scholarly journals Clinical Features and Outcomes of Immune Checkpoint Inhibitor–Associated AKI: A Multicenter Study

2020 ◽  
Vol 31 (2) ◽  
pp. 435-446 ◽  
Author(s):  
Frank B. Cortazar ◽  
Zoe A. Kibbelaar ◽  
Ilya G. Glezerman ◽  
Ala Abudayyeh ◽  
Omar Mamlouk ◽  
...  
Keyword(s):  
Adverse Events ◽  
Clinical Features ◽  
Multicenter Study ◽  
Immune Checkpoint ◽  
Immune Checkpoint Inhibitor ◽  
Tubulointerstitial Nephritis ◽  
Checkpoint Inhibitor ◽  
Fold Increase ◽  
Increased Risk ◽  
Renal Prognosis

BackgroundDespite increasing recognition of the importance of immune checkpoint inhibitor–associated AKI, data on this complication of immunotherapy are sparse.MethodsWe conducted a multicenter study of 138 patients with immune checkpoint inhibitor–associated AKI, defined as a ≥2-fold increase in serum creatinine or new dialysis requirement directly attributed to an immune checkpoint inhibitor. We also collected data on 276 control patients who received these drugs but did not develop AKI.ResultsLower baseline eGFR, proton pump inhibitor use, and combination immune checkpoint inhibitor therapy were each independently associated with an increased risk of immune checkpoint inhibitor–associated AKI. Median (interquartile range) time from immune checkpoint inhibitor initiation to AKI was 14 (6–37) weeks. Most patients had subnephrotic proteinuria, and approximately half had pyuria. Extrarenal immune-related adverse events occurred in 43% of patients; 69% were concurrently receiving a potential tubulointerstitial nephritis–causing medication. Tubulointerstitial nephritis was the dominant lesion in 93% of the 60 patients biopsied. Most patients (86%) were treated with steroids. Complete, partial, or no kidney recovery occurred in 40%, 45%, and 15% of patients, respectively. Concomitant extrarenal immune-related adverse events were associated with worse renal prognosis, whereas concomitant tubulointerstitial nephritis–causing medications and treatment with steroids were each associated with improved renal prognosis. Failure to achieve kidney recovery after immune checkpoint inhibitor–associated AKI was independently associated with higher mortality. Immune checkpoint inhibitor rechallenge occurred in 22% of patients, of whom 23% developed recurrent associated AKI.ConclusionsThis multicenter study identifies insights into the risk factors, clinical features, histopathologic findings, and renal and overall outcomes in patients with immune checkpoint inhibitor–associated AKI.

Case Review of lgG4-Related Disease Patient with Combined Tubulointerstitial Nephritis and Membranous Nephropathy Coexisting with Cholangiocarcinoma: Case Report

2020 ◽  
Vol 103 (11) ◽  
pp. 1230-1235
Keyword(s):  
Renal Failure ◽  
Membranous Nephropathy ◽  
Tubulointerstitial Nephritis ◽  
Disease Patient ◽  
Case Review ◽  
Related Disease ◽  
Phospholipase A2 Receptor ◽  
Wide Range ◽  
Serum Igg4 ◽  
Secondary Membranous Nephropathy

Immunoglobulin G4-related disease (IgG4-RD) has recently been recognized as an autoimmune disorder involving multiple organs. The kidney is a represented organ with a wide range of renal manifestations. The authors report a case of an 83-year-old Thai male with combined IgG4 tubulointerstitial nephritis and membranous nephropathy coexisting with cholangiocarcinoma. The patient presented with proteinuria, acute renal failure, eosinophilia, hypocomplementemia, and high serum IgG4 concentration. The diagnosis was IgG 4-related tubulointerstitial nephritis and membranous nephropathy on renal biopsy, with negative immunohistochemistry for anti-phospholipase A2 receptor antibodies. Magnetic resonance imaging (MRI) abdomen showed two wedge shaped arterial enhancing lesions of liver. Liver biopsy revealed adenocarcinoma, compatible with cholangiocarcinoma. Proteinuria and renal failure were resolved with initial steroid treatment. Meanwhile, IgG4-related membranous nephropathy should be considered in the differential diagnosis for patients with proteinuria. Potentially, IgG4-RD may be rarely associated with carcinoma development. However, further studies are recommended to ratify and confirm the association between IgG4-RD and incidence of malignancies. Keywords: IgG4-related disease, Membranous nephropathy, Secondary membranous nephropathy, Tubulointerstitial nephritis, Cholangiocarcinoma

Tubulointerstitial nephritis associated with a novel mitochondrial point mutation

2001 ◽  
Vol 59 (3) ◽  
pp. 846-854
Author(s):  
Chin-Yuan Tzen ◽  
Jeng-Daw Tsai ◽  
Tsu-Yen Wu ◽  
Be-Fon Chen ◽  
Mong-Liang Chen ◽  
...  
Keyword(s):  
Point Mutation ◽  
Tubulointerstitial Nephritis

Acute tubulointerstitial nephritis in children and chronic kidney disease

2019 ◽  
Vol 26 (5) ◽  
pp. 290-294 ◽  
Author(s):  
S. Clavé ◽  
C. Rousset-Rouvière ◽  
L. Daniel ◽  
M. Tsimaratos
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Tubulointerstitial Nephritis ◽  
Acute Tubulointerstitial Nephritis

scholarly journals POS-474 TUBULOINTERSTITIAL NEPHRITIS AND UVEITIS : A CASE SERIES

2021 ◽  
Vol 6 (4) ◽  
pp. S205
Author(s):  
T. JHIDRI ◽  
M. Ben Salem ◽  
A. Letaief ◽  
M. Hamouda ◽  
M. Ben salah ◽  
...  
Keyword(s):  
Tubulointerstitial Nephritis ◽  
Case Series
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