Impact on the well-being perceived by caregivers of children and adolescents with type 1 diabetes following the use of interstitial glucose measurement systems

Automated insulin delivery by means of a glucose-responsive closed-loop system has often been cited as the ‘holy grail’ of type 1 diabetes management. Reflecting the technological advances in interstitial glucose measurements and wider use of continuous glucose monitoring, recent research in closed-loop glucose control has focused on the subcutaneous route for glucose measurements and insulin delivery. The primary aim of such systems is to keep blood glucose within the target range while minimising the risk of hypoglycaemia with minimal input from the user. This article examines recent developments in the field of interstitial glucose measurement, limitations of the current generation of devices and implications on the performance of closed-loop systems. Clinical results and the advantages and disadvantages of different closed-loop configurations are summarised. Potential future advances in closed-loop systems are highlighted.

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The associations between mental health, health-related quality of life and insulin pump therapy among children and adolescents with type 1 diabetes

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem-2018-0130 ◽

2018 ◽

Vol 31 (10) ◽

pp. 1065-1072 ◽

Cited By ~ 2

Author(s):

Brigitta Munkácsi ◽

Gábor Papp ◽

Enikő Felszeghy ◽

Karolina Eszter Kovács ◽

Beáta Erika Nagy

Keyword(s):

Mental Health ◽

Type 1 Diabetes ◽

Children And Adolescents ◽

Mental Health Problems ◽

Well Being ◽

Health Problems ◽

Insulin Pump Therapy ◽

Control Group ◽

Subjective Well Being

Abstract Background Diabetes has previously been linked to mental health problems in children and adolescents, but more recent studies have yielded mixed findings. The aim of the current study was to compare symptoms of mental health problems in children and adolescents with and without type 1 diabetes (T1DM). Methods Life quality, subjective well-being, self-rated health, depression and somatic symptoms in children and adolescents with diabetes (n=130) were measured and compared to the results of a socio-demographically joined control group (n=177) which consists of healthy children and adolescents. Results A significant difference could be observed between the groups in well-being and depressive symptoms as according to the results, the research sample namely the children with T1DM could be described with significantly higher subjective well-being and mood, but with less physical symptoms and lower level of depression as those in the control group. Conclusions These findings suggest that T1DM is not associated with an increased risk of psychosocial problems, and confirm that even a severe disease of a child can lead to personal growth.

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Progress with Closed-loop Systems in Type 1 Diabetes

US Endocrinology ◽

10.17925/use.2010.06.1.58 ◽

2010 ◽

Vol 06 (01) ◽

pp. 58

Author(s):

Lalantha Leelarathna ◽

Roman Hovorka ◽

◽

Keyword(s):

Type 1 Diabetes ◽

Closed Loop ◽

Diabetes Management ◽

Insulin Delivery ◽

Glucose Measurement ◽

Target Range ◽

Advantages And Disadvantages ◽

Closed Loop Systems ◽

Interstitial Glucose

Automated insulin delivery by means of a glucose-responsive closed-loop system has often been cited as the ‘holy grail’ of type 1 diabetes management. Reflecting the technological advances in interstitial glucose measurements and wider use of continuous glucose monitoring, recent research in closed-loop glucose control has focused on the subcutaneous route for glucose measurements and insulin delivery. The primary aim of such systems is to keep blood glucose within the target range while minimizing the risk of hypoglycemia with minimal input from the user. This article examines recent developments in the field of interstitial glucose measurement, limitations of the current generation of devices and implications on the performance of closed-loop systems. Clinical results and the advantages and disadvantages of different closed-loop configurations are summarized. Potential future advances in closed-loop systems are highlighted.

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Performance of the Eversense versus the Free Style Libre Flash glucose monitor during exercise and normal daily activities in subjects with type 1 diabetes mellitus

BMJ Open Diabetes Research & Care ◽

10.1136/bmjdrc-2020-001193 ◽

2020 ◽

Vol 8 (1) ◽

pp. e001193 ◽

Cited By ~ 1

Author(s):

Marion Fokkert ◽

Peter R van Dijk ◽

Mireille A Edens ◽

Alberto Díez Hernández ◽

Robbert Slingerland ◽

...

Keyword(s):

Type 1 Diabetes ◽

Glucose Oxidase ◽

Continuous Glucose Monitoring ◽

Glucose Monitoring ◽

Daily Activities ◽

Glucose Measurement ◽

Beneficial Effects ◽

Intensive Exercise ◽

Interstitial Glucose

IntroductionAccurate blood glucose measurements are important in persons with diabetes during normal daily activities (NDA), even more so during exercise. We aimed to investigate the performance of fluorescence sensor-based and glucose oxidase-based interstitial glucose measurement during (intensive) exercise and NDA.Research design and methodsProspective, observational study in 23 persons with type 1 diabetes when mountain biking for 6 days, followed by 6 days of NDA. Readings of the Eversense (fluorescence-based continuous glucose monitoring (CGM); subcutaneously implanted) and of the Free Style Libre (FSL; glucose oxidase-based flash glucose monitoring (FGM); transcutaneously placed) were compared with capillary glucose levels (Free Style Libre Precision NeoPro strip (FSLCstrip)).ResultsMean average differences (MAD) and mean average relative differences (MARD) were significantly different when comparing exercise with NDA (reference FSLCstrip); Eversense MAD 25±19 vs 17±6 mg/dL (p<0.001); MARD 17±6 vs 13%±6% (p<0.01) and FSL MAD 32±17 vs 18±8 mg/dL (p<0.01); MARD 20±7 vs 12%±5% (p<0.001).When analyzing the data according to the Integrated Continuous Glucose Monitoring Approvals (class II–510(K) guidelines), the overall performance of interstitial glucose readings within 20% of the FSLCstrip during exercise compared with NDA was 69% vs 81% for the Eversense and 59% vs 83% for the FSL, respectively. Within 15% of the FSLCstrip was 59% vs 70% for the Eversense and 46% vs 71% for the FSL.ConclusionsDuring exercise, both fluorescence and glucose oxidase-based interstitial glucose measurements (using Eversense and FSL sensors) were less accurate compared with measurements during NDA. Even when acknowledging the beneficial effects of CGM or FGM, users should be aware of the risk of diminished accuracy of interstitial glucose readings during (intensive) exercise.

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Diabetes Summer Camp in children and adolescents with type 1 diabetes: Effects on well-being and quality of life

Endocrinología Diabetes y Nutrición (English ed ) ◽

10.1016/j.endien.2019.08.008 ◽

2020 ◽

Vol 67 (5) ◽

pp. 326-332

Author(s):

María Teresa Anarte ◽

Mónica Carreira ◽

Ana Leiva Gea ◽

Esperanza Varela ◽

Marta Mateo-Anarte ◽

...

Keyword(s):

Quality Of Life ◽

Type 1 Diabetes ◽

Children And Adolescents ◽

Summer Camp ◽

Well Being

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Diabetes Summer Camp in children and adolescents with type 1 diabetes: Effects on well-being and quality of life

Endocrinología Diabetes y Nutrición ◽

10.1016/j.endinu.2019.08.002 ◽

2020 ◽

Vol 67 (5) ◽

pp. 326-332 ◽

Cited By ~ 1

Author(s):

María Teresa Anarte ◽

Mónica Carreira ◽

Ana Leiva Gea ◽

Esperanza Varela ◽

Marta Mateo-Anarte ◽

...

Keyword(s):

Quality Of Life ◽

Type 1 Diabetes ◽

Children And Adolescents ◽

Summer Camp ◽

Well Being

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Fear of hypoglycemia, anxiety, and subjective well-being in parents of children and adolescents with type 1 diabetes

Journal of Health Psychology ◽

10.1177/1359105316650931 ◽

2016 ◽

Vol 24 (2) ◽

pp. 209-218 ◽

Cited By ~ 13

Author(s):

Tanja Pate ◽

Simona Klemenčič ◽

Tadej Battelino ◽

Nataša Bratina

Keyword(s):

Type 1 Diabetes ◽

Children And Adolescents ◽

Diabetes Management ◽

Severe Hypoglycemia ◽

Well Being ◽

Subjective Well Being ◽

Paired Samples ◽

Fear Of Hypoglycemia ◽

Fear And Anxiety

This study explored the association between parental fear of hypoglycemia, anxiety, and subjective well-being in parents of children and adolescents with type 1 diabetes. A total of 120 mothers and 79 fathers participated. Mothers’ and fathers’ fear of hypoglycemia was significantly associated with anxiety and negative affect as well as with worse glycemic control in child. Paired-samples t-test showed that mothers were more involved in diabetes management and reported more fear and anxiety compared to fathers, but they did not differ in worries about hypoglycemia. The findings suggest screening for fear of hypoglycemia and subjective well-being in all parents regardless of whether their child experienced severe hypoglycemia.

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