The effect of concrete fatigue on the cyclic behaviour of composite dowels - derivation of a design approach based on experimental findings

2022 ◽  
Vol 253 ◽  
pp. 113743
Author(s):  
Georgios Christou ◽  
Christopher Schmidt ◽  
Josef Hegger ◽  
Martin Classen
Keyword(s):  
Design Approach ◽  
Cyclic Behaviour ◽  
Experimental Findings

When are our experimental findings better than a guess?

2013 ◽  
Author(s):  
Clintin Davis-Stober ◽  
Jason Dana
Keyword(s):  
Experimental Findings ◽  
Better Than

Radiopharmacology: Hazard or/and Benefit

1984 ◽  
Vol 23 (02) ◽  
pp. 87-91 ◽  
Author(s):  
K. Flemming
Keyword(s):  
Ionizing Radiation ◽  
Late Effects ◽  
Radiation Risk ◽  
Dose Effect ◽  
Radiation Hazard ◽  
Radiation Doses ◽  
Low Doses ◽  
Medical Radiology ◽  
Experimental Findings ◽  
In The Beginning

SummaryIn the beginning of medical radiology, only the benefit of ionizing radiation was obvious, and radiation was handled and applied generously. After late effects had become known, the radiation exposure was reduced to doses following which no such effects were found. Thus, it was assumed that one could obtain an optimal medical benefit without inducing any hazard. Later, due to experimental findings, hypotheses arose (linear dose-effect response, no time factor) which led to the opinion that even low and lowest radiation doses were relevant for the induction of late effects. A radiation fear grew, which was unintentionally strengthened by radiation protection decrees: even for low doses a radiation risk could be calculated. Therefore, it was believed that there could still exist a radiation hazard, and the radiation benefit remained in question. If, however, all presently known facts are considered, one must conclude that large radiation doses are hazardous and low doses are inefficient, whereas lowest doses have a biopositive effect. Ionizing radiation, therefore, may cause both, hazard as well as benefit. Which of the two effects prevails is determined by the level of dose.

Automation of Two-Stage Factor VIII Assay

1978 ◽  
Vol 39 (02) ◽  
pp. 455-465 ◽  
Author(s):  
Yvonne Stirling ◽  
D J Howarth ◽  
Marguerite Vickers ◽  
W R S North ◽  
T W Meade
Keyword(s):  
Factor Viii ◽  
Optical Density ◽  
Electric Circuit ◽  
Clotting Time ◽  
Two Stage ◽  
Laboratory Error ◽  
Premature Closure ◽  
Factor Viii Concentrates ◽  
Experimental Findings ◽  
Automated Methods

SummaryTwo automated methods for two-stage factor VIII assays have been compared with one another, and evaluated in practice. The Depex method records the clotting time when an electric circuit is completed by the formation of a fibrin thread across a hook-type electrode; the Electra method is based on an optical density technique of clot detection. The two methods gave comparable results for measured levels of factor VIII when haemophilic or “normal” plasmas were assayed. Results from the two methods in practice also suggest that both are valid at low and “normal” factor VIII levels. The Electra method is also probably suitable for assays of concentrates; however, the Depex method appears to give falsely high values in these circumstances, and experimental findings suggest that the reason may be that increased viscosity due to the high fibrinogen levels in factor VIII concentrates causes premature closure of the circuit between the two ends of the Depex electrode. The main advantage of the Depex method is that, provided 3 or 4 machines are available, a given number of assays can be completed more quickly than on Electra. The main advantages of Electra are that it is probably subject to less laboratory error than Depex, and that it is suitable for assaying concentrates as well as haemophilic and “normal” plasmas.

In Vitro Studies on the Mechanism of the Antifibrino-lytic Action of E-Aminocaproic Acid (EACA)

1968 ◽  
Vol 19 (03/04) ◽  
pp. 584-592 ◽  
Author(s):  
Hanna Lukasiewicz ◽  
S Niewiarowski
Keyword(s):  
Aminocaproic Acid ◽  
Test Tube ◽  
In Vitro Studies ◽  
Lytic Action ◽  
Human Plasminogen ◽  
Experimental Findings ◽  
Fibrin Clots

Summary and Conclusion1. It has been found that EACA does not inhibit activation of human plasminogen into plasmin by SK and UK in a concentration of 5 × 10–2 M. The activation of bovine plasminogen by SK and UK is inhibited by this concentration of EACA but not by a lower one.2. EACA in concentrations of 1,5 × 10–1 – 10–4 M does not inhibit casein proteolysis by plasmin. The proteolysis of fibrinogen and fibrin measured by the release of TCA soluble tyrosine is inhibited by EACA in concentrations of 1,5 × 10–1 – 10–2 M.3. The lysis of non-stabilized clots by plasmin measured in a test tube was inhibited by an EACA concentration of 5 × 10–3 – 5 × 10–4 M. The lysis of stabilized clots by plasmin was inhibited by an EACA concentration of 10–5 M.4. On the basis of experimental findings and data given in literature the authors postulate that the mechanism of the antifibrinolytic effects of EACA consists mainly in a modification of plasmin action on fibrin. These effects are dependent on the structure of the fibrin clots.

Towards a Tangible Philosophy through Design

2019 ◽  
Vol 2 (1) ◽  
Author(s):  
Jelle VAN DIJK ◽  
Jonne VAN BELLE ◽  
Wouter EGGINK
Keyword(s):  
Digital Age ◽  
Promising Method ◽  
Design Approach ◽  
The World ◽  
First Results

The combined philosophy and design approach called Philosophy-through-Design (PtD) is proposed using an exemplary project about being-in-the-world in the digital age. PtD is a practical way to do philosophy through designing interventions, and involves various people in the exploration of philosophical concepts. It stems from the overlapping questions found in philosophy and design regarding human-technology interaction. By intertwining both, they benefit from describing, understanding and proposing human-technology interactions to unfold new questions and perspectives. In the exemplary project, being-in-the-world refers to a way of being that is embodied, active, open-ended and situational, based on the phenomenological and embodied theories of Tim Ingold. This concept questions what it means to be human in the digital age and how our lives with technology are built. The first results show the process of weaving together observation, creation and reflection, which presents Philosophy-through-Design as a promising method for designers to practice a tangible philosophy.

Loss of Control in Alcoholism; An Investigation of the Hypothesis, with Experimental Findings

1973 ◽  
Vol 34 (4) ◽  
pp. 1146-1161 ◽  
Author(s):  
Alfonso Paredes ◽  
William R. Hood ◽  
Harry Seymour ◽  
Maury Gollob
Keyword(s):  
Loss Of Control ◽  
Experimental Findings

Design of Prestressed Flexural Sections by the Unified Design Approach

PCI Journal ◽  
1999 ◽  
Vol 44 (5) ◽  
pp. 72-81 ◽  
Author(s):  
Javeed A. Munshi
Keyword(s):  
Design Approach ◽  
Unified Design

Rancangan Lowongan Kerja Online Menggunakan Metode User Centered Design (Studi Kasus: Business Placement Center STMIK AMIKOM Yogyakarta)

2016 ◽  
Vol 3 (1) ◽  
pp. 62
Author(s):  
Rhomita Sari ◽  
Ema Utami ◽  
Armadyah Amborowati
Keyword(s):  
Research Methodology ◽  
Design Approach ◽  
User Centered Design ◽  
Analysis And Design ◽  
Job Vacancy ◽  
Placement Center ◽  
User Centered

Business Placement Center membantu mengelola website alumni dalam memenuhi kebutuhan alumni salah satunya memberikan informasi mengenai lowongan pekerjaan. Website Alumni Amikom sudah memberikan informasi mengenai lowongan pekerjaan. Namun website alumni masih perlu ditambahkan fitur-fitur menu penunjang dalam mempermudah pencarian informasi pekerjaan yang sesuai keinginan pengguna. Penggunaan metode User Centered Design untuk mempermudah pengguna dalam menggunakan fasilitas yang ada pada website ketika mencari informasi lowongan pekerjaan dan pengguna berperan penting dalam setiap proses UCD. Dengan pendekatan User Centered Design diharapkan dapat menghasilkan tampilan dan fungsionalitas yang maksimal pada rancangan sistem yang dibangun sehingga sesuai dengan kebutuhan pengguna. Metode penelitian yang dilakukan yaitu observasi, wawancara dan kuesioner untuk mengetahui kebutuhan pengguna. Analisis dan perancangan menggunakan pendekatan User Centered Design dan implementasi perancangan sistem. Hasil penelitiannya adalah pengguna merasa nyaman dengan tampilan antarmuka website yang sudah dibangun, informasi yang disajikan mudah dipahami dan fitur-fitur menu sudah berhasil berjalansesuai fungsi.Business Placement Center help manage the website for the needs of alumnus one of them is to provide information on a vacancy. The alumnus website’s provides information about job vacancy. The website still need the support to facilitate the searching all the features the work in accordance with what the use. The method of user centered design to make it easy for users in the use of the existing facilities at the website while searching for information a vacancy and users play an important role in any proses UCD. User Centered Design approach is expected to produce the interface and functionality maximal built in the system so that in accordance with the need of users. Research methodology was by observation, interviews and quesionnaires to find out the need of users. Analysis and design using UCD approach and implementation of the system. The results of research is users feel comfortable with a display interface of website which have been built, the information is easily understood and menu features has been successfully run a function.

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