scholarly journals Mechanisms for tissue-specific accumulation and phase I/II transformation of 6:2 fluorotelomer phosphate diester in earthworm (M. guillelmi)

2021 ◽  
Vol 151 ◽  
pp. 106451
Author(s):  
Yumin Zhu ◽  
Yibo Jia ◽  
Menglin Liu ◽  
Liping Yang ◽  
Shujun Yi ◽  
...  
Keyword(s):  
Phase I ◽  
Tissue Specific ◽  
Phosphate Diester ◽  
Specific Accumulation

Tissue-specific accumulation of carotenoids in carrot roots

Planta ◽  
2006 ◽  
Vol 224 (5) ◽  
pp. 1028-1037 ◽  
Author(s):  
Malgorzata Baranska ◽  
Rafal Baranski ◽  
Hartwig Schulz ◽  
Thomas Nothnagel
Keyword(s):  
Tissue Specific ◽  
Specific Accumulation

scholarly journals Synaptic and epidermal accumulations of human acetylcholinesterase are encoded by alternative 3'-terminal exons.

1995 ◽  
Vol 15 (6) ◽  
pp. 2993-3002 ◽  
Author(s):  
S Seidman ◽  
M Sternfeld ◽  
R Ben Aziz-Aloya ◽  
R Timberg ◽  
D Kaufer-Nachum ◽  
...  
Keyword(s):  
Neuromuscular Junctions ◽  
Gene Transcript ◽  
Dna Encoding ◽  
Tissue Specific ◽  
Evolutionarily Conserved ◽  
Low Salt ◽  
Catalytically Active ◽  
Specific Accumulation ◽  
The Brain ◽  
Muscle Ache

Tissue-specific heterogeneity among mammalian acetylcholinesterases (AChE) has been associated with 3' alternative splicing of the primary AChE gene transcript. We have previously demonstrated that human AChE DNA encoding the brain and muscle AChE form and bearing the 3' exon E6 (ACHE-E6) induces accumulation of catalytically active AChE in myotomes and neuromuscular junctions (NMJs) of 2- and 3-day-old Xenopus embryos. Here, we explore the possibility that the 3'-terminal exons of two alternative human AChE cDNA constructs include evolutionarily conserved tissue-recognizable elements. To this end, DNAs encoding alternative human AChE mRNAs were microinjected into cleaving embryos of Xenopus laevis. In contrast to the myotomal expression demonstrated by ACHE-E6, DNA carrying intron 14 and alternative exon E5 (ACHE-I4/E5) promoted punctuated staining of epidermal cells and secretion of AChE into the external medium. Moreover, ACHE-E6-injected embryos displayed enhanced NMJ development, whereas ACHE-I4/E5-derived enzyme was conspicuously absent from muscles and NMJs and its expression in embryos had no apparent effect on NMJ development. In addition, cell-associated AChE from embryos injected with ACHE-I4/E5 DNA was biochemically distinct from that encoded by the muscle-expressible ACHE-E6, displaying higher electrophoretic mobility and greater solubility in low-salt buffer. These findings suggest that alternative 3'-terminal exons dictate tissue-specific accumulation and a particular biological role(s) of AChE, associate the 3' exon E6 with NMJ development, and indicate the existence of a putative secretory AChE form derived from the alternative I4/E5 AChE mRNA.

Transfer and tissue-specific accumulation of components in embryos of Caenorhabditis elegans and dolichura: in vivo analysis with a low-cost signal

Development ◽  
1992 ◽  
Vol 114 (2) ◽  
pp. 317-330 ◽  
Author(s):  
O. Bossinger ◽  
E. Schierenberg
Keyword(s):  
Caenorhabditis Elegans ◽  
Low Cost ◽  
Free Living ◽  
Tissue Specific ◽  
C Elegans ◽  
Specific Accumulation ◽  
In Vivo Analysis

The pattern of autofluorescence in the two free-living namatodes Rhabditis dolichura and Caenorhabditis compared. In C. elegans, during later embryogenesis cells develop a typical bluish autofluorescence as illumination, while in Rh. dolichura a strong already present in the unfertilized egg. Using a new,

Assessing hexavalent chromium tissue-specific accumulation patterns and induced physiological responses to probe chromium toxicity in Coturnix japonica quail

Chemosphere ◽  
2021 ◽  
Vol 266 ◽  
pp. 129005
Author(s):  
Damir Suljević ◽  
Jasmina Sulejmanović ◽  
Muhamed Fočak ◽  
Erna Halilović ◽  
Džemila Pupalović ◽  
...  
Keyword(s):  
Hexavalent Chromium ◽  
Physiological Responses ◽  
Coturnix Japonica ◽  
Chromium Toxicity ◽  
Tissue Specific ◽  
Specific Accumulation

scholarly journals Time-Dependent and Tissue-Specific Accumulation of mtDNA and Respiratory Chain Defects in Chronic Doxorubicin Cardiomyopathy

Circulation ◽  
2003 ◽  
Vol 108 (19) ◽  
pp. 2423-2429 ◽  
Author(s):  
Dirk Lebrecht ◽  
Bernhard Setzer ◽  
Uwe-Peter Ketelsen ◽  
Jörg Haberstroh ◽  
Ulrich A. Walker
Keyword(s):  
Respiratory Chain ◽  
Time Dependent ◽  
Tissue Specific ◽  
Specific Accumulation ◽  
Chain Defects ◽  
Respiratory Chain Defects ◽  
Doxorubicin Cardiomyopathy

Bean leaf abscission: Tissue-specific accumulation of a cellulase mRNA

Planta ◽  
1991 ◽  
Vol 186 (1) ◽  
Author(s):  
MarkL. Tucker ◽  
SusanL. Baird ◽  
Roy Sexton
Keyword(s):  
Leaf Abscission ◽  
Tissue Specific ◽  
Specific Accumulation

scholarly journals A Comparative Metabolomics Analysis Reveals the Tissue-Specific Phenolic Profiling in Two Acanthopanax Species

Molecules ◽  
2018 ◽  
Vol 23 (8) ◽  
pp. 2078 ◽  
Author(s):  
Ke-Xin Wu ◽  
Jia Liu ◽  
Yang Liu ◽  
Xiao-Rui Guo ◽  
Li-Qiang Mu ◽  
...  
Keyword(s):  
High Performance ◽  
Acanthopanax Senticosus ◽  
Liquid Chromatograph ◽  
Active Compounds ◽  
Tissue Specific ◽  
Eleutheroside B ◽  
Specific Accumulation ◽  
Comparative Metabolomics ◽  
Acanthopanax Sessiliflorus ◽  
Acanthopanax Species

Acanthopanax senticosus (Rupr. Maxim.) Harms (ASH) and Acanthopanax sessiliflorus (Rupr. Maxim.) Seem (ASS), are members of the Araliaceae family, and both are used in Asian countries. These herbals have drawn much attention in recent years due to their strong biological activity, with innocuity and little side effects. However, the common and distinct mode of compound profiles between ASH and ASS is still unclear. In this study, a high performance liquid chromatograph-mass spectrometry (HPLC-MS) method was developed to simultaneously quantify the seven major active compounds, including protocatechuate, eleutheroside B, eleutheroside E, isofraxidin, hyperoside, kaempferol and oleanolic acid. Then the targeted metabolomics were conducted to identify 19 phenolic compounds, with tight relation to the above mentioned active compounds, including nine C6C3C6-type, six C6C3-type and four C6C1-type in the two Acanthopanax species studied here. The results showed that the seven active compounds presented a similar trend of changes in different tissues, with more abundant accumulation in roots and stems for both plants. From the view of plant species, the ASH plants possess higher abundance of compounds, especially in the tissues of roots and stems. For phenolics, the 19 phenols detected here could be clearly grouped into five main clusters based on their tissue-specific accumulation patterns. Roots are the tissue for the most abundance of their accumulations. C6C3C6-type compounds are the most widely existing type in both plants. In conclusion, the tissue- and species-specificity in accumulation of seven active compounds and phenolics were revealed in two Acanthopanax species.

Sign in / Sign up

Export Citation Format

Share Document