N-Acetyl cysteine abates hepatorenal toxicities induced by perfluorooctanoic acid exposure in male rats

2021 ◽  
pp. 103667
Author(s):  
Solomon Owumi ◽  
Taofeek Bello ◽  
Adegboyega K. Oyelere
Keyword(s):  
Perfluorooctanoic Acid ◽  
Acid Exposure ◽  
Male Rats ◽  
Acetyl Cysteine

N ‐acetyl cysteine co‐treatment abates perfluorooctanoic acid‐induced reproductive toxicity in male rats

Andrologia ◽  
2021 ◽  
Author(s):  
Solomon E. Owumi ◽  
Ayomide P. Akomolafe ◽  
Innocent O. Imosemi ◽  
Oyeronke A. Odunola ◽  
Adegboyega K. Oyelere
Keyword(s):  
Reproductive Toxicity ◽  
Perfluorooctanoic Acid ◽  
Male Rats ◽  
Acetyl Cysteine

Prenatal perfluorooctanoic acid exposure is associated with early onset atopic dermatitis in 5-year-old children

Chemosphere ◽  
2019 ◽  
Vol 231 ◽  
pp. 25-31 ◽  
Author(s):  
Hui-Ju Wen ◽  
Shu-Li Wang ◽  
Yu-Chen Chuang ◽  
Pau-Chung Chen ◽  
Yue Leon Guo
Keyword(s):  
Atopic Dermatitis ◽  
Early Onset ◽  
Perfluorooctanoic Acid ◽  
Acid Exposure

scholarly journals POTENTIAL ROLE OF ANNONA SQUAMOSA LINN EXTRACT AND N-ACETYL CYSTEINE IN MANAGEMENT OF RIFAMPICIN-INDUCED HEPATOXICITY IN RATS

2020 ◽  
pp. 117-123
Author(s):  
BOSY AZMY ABD EL MOTELP ◽  
HADER FAWZY DARWISH ◽  
SAMIHA MOHAMED ABD ELDAYEM ◽  
FATMA MOKHTAR FOUDA
Keyword(s):  
Total Protein ◽  
Liver Tissue ◽  
Inflammatory Marker ◽  
Normal Structure ◽  
Hepatoprotective Activity ◽  
Male Rats ◽  
Annona Squamosa ◽  
Apoptotic Marker ◽  
Acetyl Cysteine ◽  
Marker Level

Objective: Rifampicin (RIF) could be a recognized therapeutic and preventive agent against tuberculosis. Still, high rates of many side effects and symptoms related to hepatotoxicity have identified during treatment. So, the current study was aimed to evaluate the antioxidant and hepatoprotective activity of methanolic extract of Annona Squamosa Linn (MEAS) and N-Acetyl Cysteine (NAC) against RIF induced hepatic injury in male rats. Methods: The hepatoprotective effects of MEAS (500 mg/kg b.wt.) and NAC (100 mg/kg b.wt.) or co-treatment were assessed in a model of hepatotoxicity by RIF (300 mg/kg b. wt.) in male rats daily for 21 d. Moreover, bilirubin, total protein, albumin, ALT, AST, ALP, GGT, MDA, and GSH were estimated. In addition, the levels of IL-6, IL-10, 8(OH)dG, and Bcl2 were evaluated. Results: The oral administration of MEAS and NAC or their combination resulted in significant reductions in the levels of bilirubin, albumin, hepato-specific markers namely ALT, AST, ALP, GGT, and MDA as compared to the RIF group. Furthermore, MEAS and NAC or the combination of MEAS and NAC treatment significantly up-regulated the levels of total protein, glutathione reductase with concomitant decrease in inflammatory marker level IL-6 and apoptotic marker level 8(OH)dG as well as increment the level of anti-inflammatory marker IL-10 and anti-apoptotic marker Bcl2 as compared to the RIF group. Histological examination of the liver tissue indicated that co-treatment with MEAS and NAC completely abolished the inflammation and degeneration in hepatocytes and restore the liver tissue to its normal structure. Conclusion: The present findings demonstrated that a co-treatment of MEAS and NAC seems to be more productive and curative than alone MEAS or NAC treatment and strongly compensated the liver damage induced by RIF.

Impact of boric acid exposure at different concentrations on testicular DNA and male rats fertility

2013 ◽  
Vol 23 (5) ◽  
pp. 360-367 ◽  
Author(s):  
Mai H. El-Dakdoky ◽  
Hanan M. F. Abd El-Wahab
Keyword(s):  
Boric Acid ◽  
Acid Exposure ◽  
Male Rats

Ameliorative effect of N-acetyl cysteine on alpha-cypermethrin-induced pulmonary toxicity in male rats

2013 ◽  
Vol 30 (1) ◽  
pp. 26-43 ◽  
Author(s):  
Manar Hamed Arafa ◽  
Dalia AbdElmoain Mohamed ◽  
Hebatallah Husseini Atteia
Keyword(s):  
Pulmonary Toxicity ◽  
Male Rats ◽  
Ameliorative Effect ◽  
Acetyl Cysteine

scholarly journals Perfluorooctanoic acid exposure triggers oxidative stress in the mouse pancreas

2014 ◽  
Vol 1 ◽  
pp. 513-521 ◽  
Author(s):  
Lisa M. Kamendulis ◽  
Qiangen Wu ◽  
George E. Sandusky ◽  
Barbara A. Hocevar
Keyword(s):  
Oxidative Stress ◽  
Perfluorooctanoic Acid ◽  
Acid Exposure ◽  
Mouse Pancreas

Perfluorooctanoic acid exposure disturbs glucose metabolism in mouse liver

2017 ◽  
Vol 335 ◽  
pp. 41-48 ◽  
Author(s):  
Fei Zheng ◽  
Nan Sheng ◽  
Hongxia Zhang ◽  
Shengmin Yan ◽  
Jianhai Zhang ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Mouse Liver ◽  
Perfluorooctanoic Acid ◽  
Acid Exposure

Relation between perfluorooctanoic acid exposure and strokes in a large cohort living near a chemical plant

2013 ◽  
Vol 127 ◽  
pp. 22-28 ◽  
Author(s):  
Chris Simpson ◽  
Andrea Winquist ◽  
Cathy Lally ◽  
Kyle Steenland
Keyword(s):  
Perfluorooctanoic Acid ◽  
Chemical Plant ◽  
Large Cohort ◽  
Acid Exposure
Sign in / Sign up

Export Citation Format

Share Document