Ameliorative effect of N-acetyl cysteine on alpha-cypermethrin-induced pulmonary toxicity in male rats

2013 ◽  
Vol 30 (1) ◽  
pp. 26-43 ◽  
Author(s):  
Manar Hamed Arafa ◽  
Dalia AbdElmoain Mohamed ◽  
Hebatallah Husseini Atteia
Keyword(s):  
Pulmonary Toxicity ◽  
Male Rats ◽  
Ameliorative Effect ◽  
Acetyl Cysteine

N ‐acetyl cysteine co‐treatment abates perfluorooctanoic acid‐induced reproductive toxicity in male rats

Andrologia ◽  
2021 ◽  
Author(s):  
Solomon E. Owumi ◽  
Ayomide P. Akomolafe ◽  
Innocent O. Imosemi ◽  
Oyeronke A. Odunola ◽  
Adegboyega K. Oyelere
Keyword(s):  
Reproductive Toxicity ◽  
Perfluorooctanoic Acid ◽  
Male Rats ◽  
Acetyl Cysteine

Ameliorative effect of Alpinia officinarum Hance extract on nonylphenol‐induced reproductive toxicity in male rats

Andrologia ◽  
2021 ◽  
Author(s):  
Marzieh Pirzadeh ◽  
Mohammad Barary ◽  
Seyed Mohammad Hosseini ◽  
Sohrab Kazemi ◽  
Ali Akbar Moghadamnia
Keyword(s):  
Reproductive Toxicity ◽  
Male Rats ◽  
Alpinia Officinarum ◽  
Ameliorative Effect

scholarly journals Neurotoxic Effect of Fipronil in Male Wistar Rats: Ameliorative Effect of L-Arginine and L-Carnitine

Biology ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 682
Author(s):  
Yasmina K. Mahmoud ◽  
Ahmed A. Ali ◽  
Heba M. A. Abdelrazek ◽  
Tahany Saleh Aldayel ◽  
Mohamed M. Abdel-Daim ◽  
...  
Keyword(s):  
Calcium Binding ◽  
Histopathological Examination ◽  
Memory Performance ◽  
Elevated Serum ◽  
Corticosterone Level ◽  
Male Rats ◽  
Spatial Learning And Memory ◽  
Serum Corticosterone ◽  
Group I ◽  
Ameliorative Effect

The ameliorative effect of L-arginine (LA) and L-carnitine (LC) against fipronil (FPN)-induced neurotoxicity was explored. In this case, 36 adult male rats were randomly divided into six groups: group I received distilled water, group II received 500 mg/kg LA, group III received 100 mg/kg LC, group IV received 4.85 mg/kg FPN, group V received 4.85 mg/kg FPN and 500 mg/kg LA and group VI received 4.85 mg/kg FPN and 100 mg/kg LC for 6 weeks. Cognitive performance was assessed using Barnes maze (BM). Serum corticosterone, brain total antioxidant capacity (TAC), malondialdehyde (MDA) and dopamine were measured. Histopathology and immunohistochemistry of ionized calcium-binding adaptor (Iba-1), doublecortin (DCX) and serotonin (S-2A) receptors were performed. Fipronil induced noticeable deterioration in spatial learning and memory performance. In addition, FPN significantly (p < 0.05) diminished brain antioxidant defense system and dopamine coincide with elevated serum corticosterone level. Histopathological examination revealed degenerative and necrotic changes. Furthermore, Iba-1 and DCX were significantly expressed in cortex and hippocampus whereas S-2A receptors were significantly lowered in FPN group. However, administration of LA or LC alleviated FPN-induced deteriorations. In conclusion, LA and LC could be prospective candidates for mitigation of FPN-induced neurotoxicity via their antioxidant, anti-inflammatory and neuropotentiating effects.

scholarly journals POTENTIAL ROLE OF ANNONA SQUAMOSA LINN EXTRACT AND N-ACETYL CYSTEINE IN MANAGEMENT OF RIFAMPICIN-INDUCED HEPATOXICITY IN RATS

2020 ◽  
pp. 117-123
Author(s):  
BOSY AZMY ABD EL MOTELP ◽  
HADER FAWZY DARWISH ◽  
SAMIHA MOHAMED ABD ELDAYEM ◽  
FATMA MOKHTAR FOUDA
Keyword(s):  
Total Protein ◽  
Liver Tissue ◽  
Inflammatory Marker ◽  
Normal Structure ◽  
Hepatoprotective Activity ◽  
Male Rats ◽  
Annona Squamosa ◽  
Apoptotic Marker ◽  
Acetyl Cysteine ◽  
Marker Level

Objective: Rifampicin (RIF) could be a recognized therapeutic and preventive agent against tuberculosis. Still, high rates of many side effects and symptoms related to hepatotoxicity have identified during treatment. So, the current study was aimed to evaluate the antioxidant and hepatoprotective activity of methanolic extract of Annona Squamosa Linn (MEAS) and N-Acetyl Cysteine (NAC) against RIF induced hepatic injury in male rats. Methods: The hepatoprotective effects of MEAS (500 mg/kg b.wt.) and NAC (100 mg/kg b.wt.) or co-treatment were assessed in a model of hepatotoxicity by RIF (300 mg/kg b. wt.) in male rats daily for 21 d. Moreover, bilirubin, total protein, albumin, ALT, AST, ALP, GGT, MDA, and GSH were estimated. In addition, the levels of IL-6, IL-10, 8(OH)dG, and Bcl2 were evaluated. Results: The oral administration of MEAS and NAC or their combination resulted in significant reductions in the levels of bilirubin, albumin, hepato-specific markers namely ALT, AST, ALP, GGT, and MDA as compared to the RIF group. Furthermore, MEAS and NAC or the combination of MEAS and NAC treatment significantly up-regulated the levels of total protein, glutathione reductase with concomitant decrease in inflammatory marker level IL-6 and apoptotic marker level 8(OH)dG as well as increment the level of anti-inflammatory marker IL-10 and anti-apoptotic marker Bcl2 as compared to the RIF group. Histological examination of the liver tissue indicated that co-treatment with MEAS and NAC completely abolished the inflammation and degeneration in hepatocytes and restore the liver tissue to its normal structure. Conclusion: The present findings demonstrated that a co-treatment of MEAS and NAC seems to be more productive and curative than alone MEAS or NAC treatment and strongly compensated the liver damage induced by RIF.

scholarly journals Therapeutic effects of Laser and L-carnitine against amiodarone-induced pulmonary toxicity in adult male rats

2017 ◽  
Vol 16 (7) ◽  
pp. 1565
Author(s):  
Walaa A.M. El-Nahrawy ◽  
Amr M.E. Zaher ◽  
Sara M.R. Ali
Keyword(s):  
Adult Male ◽  
Pulmonary Toxicity ◽  
Male Rats ◽  
Therapeutic Effects

The Ameliorative Effect of Cleome Droserifolia (Samwa) on Myocardial Injury Associated with Diabetes in Male Rats

2017 ◽  
Vol 69 (4) ◽  
pp. 2222-2231
Author(s):  
M. M. El-Komy ◽  
M. H. Serag ◽  
A. A. Emsalam
Keyword(s):  
Myocardial Injury ◽  
Male Rats ◽  
Ameliorative Effect

Ameliorative effect of gallic acid on doxorubicin-induced cardiac dysfunction in rats

2018 ◽  
Vol 29 (1) ◽  
pp. 19-27 ◽  
Author(s):  
Temiday O. Omóbòwálé ◽  
Ademola A. Oyagbemi ◽  
Ayorinde M. Folasire ◽  
Temitayo O. Ajibade ◽  
Ebunoluwa R. Asenuga ◽  
...  
Keyword(s):  
Gallic Acid ◽  
Antineoplastic Agent ◽  
Male Rats ◽  
Protective Effects ◽  
Cardiac Damage ◽  
Antioxidant Defence ◽  
Defence System ◽  
Wistar Strain ◽  
Antioxidant Defence System ◽  
Ameliorative Effect

AbstractBackground:The use of doxorubicin (DOX) as an antineoplastic agent has been greatly limited because of the myriad of toxic sequelae associated with it. The aim of this study was to assess the protective effects of gallic acid (GA) on DOX-induced cardiac toxicity in rats.Methods:Sixty male rats (Wistar strain) were used in this study. They were divided into six groups (A–F) each containing 10 animals. Group A was the control. Rats in Groups B, C, and D were treated with DOX at the dosage of 15 mg/kg body weight i.p. Prior to this treatment, rats in Groups C and D had been treated orally with GA for 7 days at the dosage of 60 and 120 mg/kg, respectively. Animals from Groups E and F received only 60 and 120 mg/kg GA, respectively, which were administered orally for 7 days.Results:The exposure of rats to DOX led to a significant (p<0.05) decrease in the cardiac antioxidant defence system and elevation of creatine kinase myocardial band and lactate dehydrogenase. The electrocardiography results showed a significant decrease in heart rate, QRS, and QT-segment prolongation. GA alone improved the antioxidant defence system.Conclusions:The GA pretreatment significantly alleviated GA-associated ECG abnormalities, restored the antioxidant status and prevented cardiac damage.

scholarly journals N-Acetyl cysteine mitigates histopathological changes and inflammatory genes expressions in the liver of cadmium exposed rats

2021 ◽  
Vol 36 (4) ◽  
pp. e2021024
Author(s):  
Jalal Aala ◽  
Asghar Beigi Harchegani ◽  
Hanieh Akhlaghi Monsef ◽  
Zhaleh Mohsenifar ◽  
Pirooz Ebrahimi ◽  
...  
Keyword(s):  
Single Dose ◽  
Liver Tissue ◽  
Protective Role ◽  
Male Rats ◽  
Caspase 1 ◽  
Total Antioxidant ◽  
Enhanced Expression ◽  
Continuous Dose ◽  
Acetyl Cysteine ◽  
Nrf2 Expression

This study aimed to consider the expression of Nrf2, NLRP3 and caspase 1 genes, as well as oxidative stress, and the protective role of N-acetyl cysteine (NAC) in the liver of rats treated with cadmium (Cd). Male rats were randomly divided into five groups including G1 (control), G2 (single dose of Cd), G3 (continuous dose of Cd), G4 (single dose of Cd + NAC), and G5 (continuous dose of Cd + NAC). Levels of malondialdehyde (MDA) and total antioxidant capacity (TAC) were measured. Expression of Nrf2, NLRP3 and caspase 1 genes was considered using RT-PCR. NAC treatments significantly improved TAC, but decreased MDA values in rats that exposed to continuous dose of Cd (p<0.05). Exposure to continuous dose of Cd caused a significant decrease in Nrf2 expression by 2.46-fold (p<0.001), but enhanced expression of NLRP3 and Caspase 1 genes by 3.13-fold and 3.16-fold), respectively (p<0.001). Compared to rats that treated to continuous dose of Cd, NAC supplementation enhanced the expression of Nrf2 by 1.67-fold (p<0.001) and reduced the expression of NLRP3 and Caspase 1 genes by 1.39-fold (p<0.001) and 1.58-fold (p<0.001), respectively. Down-regulation of Nrf2 and overexpression of NLRP3 and caspase 1 seems to be one of the main mechanisms of Cd toxicity on liver tissue. NAC protects liver tissue against Cd-induced oxidative injuries via enhancement of Nrf2 expression and reduction of NLRP3 and caspase 1 genes.

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