Cis-bifenthrin inhibits cortisol and aldosterone biosynthesis in human adrenocortical H295R cells via cAMP signaling cascade

2021 ◽  
pp. 103784
Author(s):  
Ye Yang ◽  
Chunlei Wang ◽  
Hong Shen ◽  
Hongliang Fan ◽  
Jing Liu ◽  
...  
Keyword(s):  
Camp Signaling ◽  
Signaling Cascade ◽  
H295r Cells

scholarly journals Mapping genetic changes in the cAMP-signaling cascade in human atria

2021 ◽  
Vol 155 ◽  
pp. 10-20 ◽  
Author(s):  
Anne Garnier ◽  
Nadja I. Bork ◽  
Eric Jacquet ◽  
Svante Zipfel ◽  
Christian Muñoz-Guijosa ◽  
...  
Keyword(s):  
Camp Signaling ◽  
Signaling Cascade ◽  
Genetic Changes

scholarly journals Plasmodium falciparum sexual parasites regulate infected erythrocyte permeability

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Guillaume Bouyer ◽  
Daniela Barbieri ◽  
Florian Dupuy ◽  
Anthony Marteau ◽  
Abdoulaye Sissoko ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Infected Erythrocyte ◽  
Drug Uptake ◽  
Camp Signaling ◽  
Signaling Cascade ◽  
Asexual Parasite ◽  
Artemisinin Derivatives ◽  
Pde Inhibitors ◽  
Sexual Stages ◽  
Camp Levels

AbstractTo ensure the transport of nutrients necessary for their survival, Plasmodium falciparum parasites increase erythrocyte permeability to diverse solutes. These new permeation pathways (NPPs) have been extensively characterized in the pathogenic asexual parasite stages, however the existence of NPPs has never been investigated in gametocytes, the sexual stages responsible for transmission to mosquitoes. Here, we show that NPPs are still active in erythrocytes infected with immature gametocytes and that this activity declines along gametocyte maturation. Our results indicate that NPPs are regulated by cyclic AMP (cAMP) signaling cascade, and that the decrease in cAMP levels in mature stages results in a slowdown of NPP activity. We also show that NPPs facilitate the uptake of artemisinin derivatives and that phosphodiesterase (PDE) inhibitors can reactivate NPPs and increase drug uptake in mature gametocytes. These processes are predicted to play a key role in P. falciparum gametocyte biology and susceptibility to antimalarials.

cAMP Signaling Cascade: A Promising Role in Ethanol Tolerance and Dependence

2001 ◽  
Vol 25 (s1) ◽  
pp. 46S-48S ◽  
Author(s):  
Subhash C. Pandey ◽  
Toshikazu Saito ◽  
M. Yoshimura ◽  
H. Sohma ◽  
M. E. Gotz
Keyword(s):  
Ethanol Tolerance ◽  
Camp Signaling ◽  
Signaling Cascade

cAMP signaling cascade is reduced in hippocampal LTP of HPC-1/syntaxin 1A knock-out mice

2007 ◽  
Vol 58 ◽  
pp. S190
Author(s):  
Tatsuya Mishima ◽  
Tomonori Fujiwara ◽  
Takefumi Kofuji ◽  
Kimio Akagawa
Keyword(s):  
Camp Signaling ◽  
Signaling Cascade ◽  
Syntaxin 1A ◽  
Knock Out ◽  
Knock Out Mice
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