scholarly journals Two Pronged Approach for Prevention and Therapy of Covid-19 (Sars-CoV-2) by a Multi-targeted herbal Drug, a component of Ayurvedic decoction

2020 ◽  
pp. 101268
Author(s):  
Richa Shukla ◽  
Sangeeta Singh ◽  
Anirudh Singh ◽  
Krishna Misra
Keyword(s):  
Herbal Drug ◽  
Prevention And Therapy

Study of quality assurance in prevention and therapy of pressure sores by measurement of overlay pressure with test persons on different prophylaxis systems

Pflege ◽  
2000 ◽  
Vol 13 (5) ◽  
pp. 297-305 ◽  
Author(s):  
Stefan Roales-Welsch ◽  
Antaszek ◽  
Hense ◽  
Pfeiffer ◽  
Freyenhagen ◽  
...  
Keyword(s):  
Quality Assurance ◽  
Pressure Sores ◽  
Os Coccygis ◽  
Prevention And Therapy

In dieser Studie zur Qualitätssicherung in der Prophylaxe und Therapie des Dekubitus durch Auflagedruckmessungen bei Probanden auf sechs Weichlagerungs- und fünf Wechseldrucksystemen war die Zielsetzung, eine Ist-Analyse der am Klinikum eingesetzten Antidekubitushilfsmittel durchzuführen. Außerdem galt es herauszufinden, ob die angewandte Methode der pneumatischen Druckmessung mit Probanden auch im Versorgungsalltag verwendbar ist. Können verlässliche und valide Messdaten erwartet werden, wenn man bei betroffenen Patienten Messungen durchführt? Zur Beantwortung dieser Fragen wurden bei 23/19 Probanden, auch in Seitenlage, durch das Platzieren von Messmatten zwischen Körper und unterschiedliche Antidekubitussysteme Messungen durchgeführt. Bei den Weichlagerungssystemen kann an allen Messorten eine signifikante Druckreduzierung (p < 0,05), am Os coccygis eine hochsignifikante Druckreduzierung (p < 0,01) nachgewiesen werden. Bei den Wechseldrucksystemen liegt der Mittelwert der maximalen Druckbelastung über 12 min bei unterschiedlicher Amplitude (75,47 mmHg–5 mmHg) und verschiedener Frequenz (1,5 min–10 min) zwischen 56,39 mmHg und 38,94 mmHg.

The effects of the multi-herbal drug STW5 on intestinal inflammation and motility

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
L Marx ◽  
D Grundmann ◽  
D Schreiber ◽  
D Simon ◽  
A Braun ◽  
...  
Keyword(s):  
Intestinal Inflammation ◽  
Herbal Drug

Abdominal Aortic Aneurysm (AAA): Is There a Role for the Prevention and Therapy Using Antioxidants?

2018 ◽  
Vol 19 (11) ◽  
pp. 1256-1264 ◽  
Author(s):  
Joël Pincemail ◽  
Jean-Olivier Defraigne ◽  
Audrey Courtois ◽  
Adelin Albert ◽  
Jean-Paul Cheramy-Bien ◽  
...  
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Abdominal Aortic ◽  
Prevention And Therapy

Comparing Effectiveness of a Combined Herbal Drug Based on Echium Amoenum with Citalopram in the Treatment of Major Depressive Disorder

2019 ◽  
Vol 16 (2) ◽  
pp. 232-238 ◽  
Author(s):  
Majid Anushiravani ◽  
Ali A. Manteghi ◽  
Ali Taghipur ◽  
Mahdi Eslami
Keyword(s):  
Randomized Controlled Trial ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Controlled Trial ◽  
Herbal Drug ◽  
Medical Sciences ◽  
Major Depressive ◽  
Dsm 5 ◽  
Randomized Controlled ◽  
Echium Amoenum

Background: According to new studies, only 60% of depressed patients respond to pharmaceutical treatment while suffering from their side effects. Natural products as adjuvant or alternative therapies should be examined to find safer and more effective ways to cope with depression. Objective: To find out the potential benefits of a combined herbal drug based on Echium amoenum compared with citalopram in the treatment of Major Depressive Disorder. Design and Setting: In psychiatry clinics of Mashhad University of Medical Sciences, 50 patients who met the criteria for Major Depressive Disorder based on DSM-5 were studied in a parallel randomized controlled trial. Design and Setting: In psychiatry clinics of Mashhad University of Medical Sciences, 50 patients who met the criteria for Major Depressive Disorder based on DSM-5 were studied in a parallel randomized controlled trial. Intervention: Subjects were randomly assigned to receive Echium amoenum compound syrup (EACS) or citalopram tablet for 8 weeks. Outcome Measures: The efficacy of treatments and recurrence of disease were surveyed and compared according to Hamilton depression rating scale at weeks 0, 4, 8, 12. Results: Patients in both groups of citalopram and EACS showed remarkable reduction in scores of Hamilton questionnaire. At the eighth week of treatment, the mean scores in EACS group were significantly lower than citalopram group (p-value = 0.03). 52% of patients suffered from various complications in citalopram group while just 12% of patients in EACS group reported few complications. Conclusion: Clinical efficacy of this herbal drug was significantly higher than citalopram, and complications were also less and lower in EACS group. Further studies with larger groups and para-clinical assessments such as serologic tests and QEEG would improve our understanding of the impacts and mechanisms of EACS.

A Review of Recent Patents (2016-2019) on Plant Food Supplements with Potential Application in the Treatment of Neurodegenerative and Metabolic Disorders

2020 ◽  
Vol 11 (2) ◽  
pp. 145-153 ◽  
Author(s):  
Rosalba Leuci ◽  
Leonardo Brunetti ◽  
Antonio Laghezza ◽  
Paolo Tortorella ◽  
Fulvio Loiodice ◽  
...  
Keyword(s):  
Metabolic Disorders ◽  
Food Supplements ◽  
Plant Food ◽  
Fortified Foods ◽  
Patent Review ◽  
Novel Strategy ◽  
Lifestyle Related Diseases ◽  
Near Future ◽  
Prevention And Therapy

In the near future, it is expected that the prevalence of illnesses related to the increasing life expectancies and quality of life, such as neurodegenerative diseases and cardiovascular diseases related to metabolic disorders, will soar to unprecedented levels, leading to high socioeconomic costs. To address this rising threat, natural products are emerging as a novel strategy for the prevention and therapy of these ages- and lifestyle-related diseases, thanks to their high marketability and few side effects. In this patent review, we summarize selected patents for food supplements, functional and fortified foods, filed from 2016 to 2019, categorizing them based on the biological activity of their components.

scholarly journals Modulation of Nrf2 and NF-κB Signaling Pathways by Naturally Occurring Compounds in Relation to Cancer Prevention and Therapy. Are Combinations Better Than Single Compounds?

2021 ◽  
Vol 22 (15) ◽  
pp. 8223
Author(s):  
Violetta Krajka-Kuźniak ◽  
Wanda Baer-Dubowska
Keyword(s):  
Cancer Prevention ◽  
Signaling Pathways ◽  
Current Knowledge ◽  
Cancer Chemoprevention ◽  
Antioxidant Response ◽  
Natural Food ◽  
Related Factor ◽  
Nuclear Factor ◽  
Edible Plant ◽  
Prevention And Therapy

Nrf2 (nuclear factor erythroid 2-related factor 2) and NF-κB (nuclear factor–kappa B) signaling pathways play a central role in suppressing or inducing inflammation and angiogenesis processes. Therefore, they are involved in many steps of carcinogenesis through cooperation with multiple signaling molecules and pathways. Targeting both transcription factors simultaneously may be considered an equally important strategy for cancer chemoprevention and therapy. Several hundreds of phytochemicals, mainly edible plant and vegetable components, were shown to activate Nrf2 and mediate antioxidant response. A similar number of phytochemicals was revealed to affect NF-κB. While activation of Nrf2 and inhibition of NF-κB may protect normal cells against cancer initiation and promotion, enhanced expression and activation in cancer cells may lead to resistance to conventional chemo- or radiotherapy. Most phytochemicals, through different mechanisms, activate Nrf2, but others, such as luteolin, can act as inhibitors of both Nrf2 and NF-κB. Despite many experimental data confirming the above mechanisms currently, limited evidence exists demonstrating such activity in humans. Combinations of phytochemicals resembling that in a natural food matrix but allowing higher concentrations may improve their modulating effect on Nrf2 and NF-κB and ultimately cancer prevention and therapy. This review presents the current knowledge on the effect of selected phytochemicals and their combinations on Nrf2 and NF-κB activities in the above context.

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