Spatial working memory in obsessive–compulsive disorder improves with clinical response: A functional MRI study

AbstractA computerized version of the object alternation test (OAT) was employed in unmedicated obsessive–compulsive disorder (OCD) patients and matched healthy controls. OCD patients performed normally on the OAT but scored below controls on a task assessing visuo-spatial working memory. The results challenge the concept of the OAT as a sensitive instrument for orbitofrontal dysfunction in OCD.

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Spatial working memory deficits in obsessive compulsive disorder are associated with excessive engagement of the medial frontal cortex

NeuroImage ◽

10.1016/j.neuroimage.2003.05.001 ◽

2003 ◽

Vol 20 (4) ◽

pp. 2271-2280 ◽

Cited By ~ 80

Author(s):

N VANDERWEE ◽

N RAMSEY ◽

J JANSMA ◽

D DENYS ◽

H VANMEGEN ◽

...

Keyword(s):

Working Memory ◽

Frontal Cortex ◽

Obsessive Compulsive Disorder ◽

Spatial Working Memory ◽

Memory Deficits ◽

Medial Frontal Cortex ◽

Obsessive Compulsive ◽

Compulsive Disorder

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Intrinsic brain abnormalities in drug-naive patients with obsessive-compulsive disorder: A resting-state functional MRI study

Journal of Affective Disorders ◽

10.1016/j.jad.2018.11.080 ◽

2019 ◽

Vol 245 ◽

pp. 861-868 ◽

Cited By ~ 8

Author(s):

Xi Yang ◽

Xinyu Hu ◽

Wanjie Tang ◽

Bin Li ◽

Yanchun Yang ◽

...

Keyword(s):

Functional Mri ◽

Obsessive Compulsive Disorder ◽

Resting State ◽

Brain Abnormalities ◽

Obsessive Compulsive ◽

Compulsive Disorder ◽

Drug Naïve ◽

Mri Study

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Cerebral activation in children and adolescents with obsessive–compulsive disorder before and after treatment: A functional MRI study

Journal of Psychiatric Research ◽

10.1016/j.jpsychires.2007.12.007 ◽

2008 ◽

Vol 42 (13) ◽

pp. 1051-1059 ◽

Cited By ~ 46

Author(s):

Luisa Lázaro ◽

Xavier Caldú ◽

Carme Junqué ◽

Núria Bargalló ◽

Susana Andrés ◽

...

Keyword(s):

Children And Adolescents ◽

Functional Mri ◽

Obsessive Compulsive Disorder ◽

Obsessive Compulsive ◽

Cerebral Activation ◽

Compulsive Disorder ◽

Before And After ◽

Mri Study

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Duration effect of obsessive-compulsive disorder on cognitive function: a functional MRI study

Depression and Anxiety ◽

10.1002/da.20484 ◽

2009 ◽

Vol 26 (9) ◽

pp. 814-823 ◽

Cited By ~ 15

Author(s):

Tomohiro Nakao ◽

Akiko Nakagawa ◽

Takashi Yoshiura ◽

Eriko Nakatani ◽

Maiko Nabeyama ◽

...

Keyword(s):

Cognitive Function ◽

Functional Mri ◽

Obsessive Compulsive Disorder ◽

Obsessive Compulsive ◽

Compulsive Disorder ◽

Duration Effect ◽

Mri Study

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Reduced efficacy of the spatial working memory system in obsessive compulsive disorder

NeuroImage ◽

10.1016/s1053-8119(01)92436-x ◽

2001 ◽

Vol 13 (6) ◽

pp. 1109

Author(s):

Nic Van der Wee ◽

Martijn Jansma ◽

Harold van Megen ◽

H. Westenberg ◽

R.S. Kahn ◽

...

Keyword(s):

Working Memory ◽

Obsessive Compulsive Disorder ◽

Spatial Working Memory ◽

Memory System ◽

Obsessive Compulsive ◽

Compulsive Disorder

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Spatial working memory performance in people with obsessive–compulsive disorder, their unaffected first-degree relatives and healthy controls

BJPsych Open ◽

10.1192/bjo.2021.1052 ◽

2021 ◽

Vol 7 (6) ◽

Author(s):

Stephan Heinzel ◽

Katharina Bey ◽

Rosa Grützmann ◽

Julia Klawohn ◽

Christian Kaufmann ◽

...

Keyword(s):

Working Memory ◽

Obsessive Compulsive Disorder ◽

Spatial Working Memory ◽

Memory Performance ◽

Age Effects ◽

Healthy Controls ◽

Obsessive Compulsive ◽

Compulsive Disorder ◽

First Degree Relatives ◽

Healthy Control

Summary Studies have shown that people with obsessive–compulsive disorder (OCD) have impairments in spatial working memory (SWM) performance. However, it remains unclear whether this deficit represents a cognitive endophenotype preceding symptoms or a correlate of OCD. We investigated SWM in 69 people with OCD, 77 unaffected first-degree relatives of people with OCD and 106 healthy control participants. Taking age effects into account, SWM performance was best in healthy controls, intermediate in relatives and worst in OCD participants. However, since performance did not differ significantly between healthy controls and relatives, our study does not fully support SWM performance as a core cognitive endophenotype of OCD.

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