The role of spatial store and executive strategy in spatial working memory: a comparison between patients with obsessive–compulsive disorder and controls

2018 ◽  
Vol 24 (1) ◽  
pp. 14-27
Author(s):  
Giampaolo Perna ◽  
Paolo Cavedini ◽  
Alice Riva ◽  
Nunzia Valentina Di Chiaro ◽  
Mara Bellotti ◽  
...  
Keyword(s):  
Working Memory ◽  
Obsessive Compulsive Disorder ◽  
Spatial Working Memory ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

Differential role of visuospatial working memory in the propensity toward uncertainty in patients with obsessive–compulsive disorder and in healthy subjects

2013 ◽  
Vol 44 (10) ◽  
pp. 2113-2124 ◽  
Author(s):  
V. Lambrecq ◽  
J.-Y. Rotge ◽  
N. Jaafari ◽  
B. Aouizerate ◽  
N. Langbour ◽  
...  
Keyword(s):  
Working Memory ◽  
Obsessive Compulsive Disorder ◽  
Healthy Subjects ◽  
Memory Performance ◽  
Continuous Performance ◽  
Visuospatial Working Memory ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Temporal Direction

BackgroundObsessive–compulsive disorder (OCD) is associated with visuospatial working memory deficits. Intolerance of uncertainty is thought to be a core component of OCD symptoms. Recent findings argue for a possible relationship between abilities in visuospatial memory and uncertainty. However, this relationship remains unclear in both OCD patients and healthy subjects. To address this issue, we measured performance in visuospatial working memory and the propensity to express uncertainty during decision making. We assessed their relationship and the temporal direction of this relationship in both OCD patients and healthy subjects.MethodBaseline abilities in visuospatial working memory were measured with the Corsi block-tapping test. A delayed matching-to-sample task was used to identify explicit situations of certainty, uncertainty and ignorance and to assess continuous performance in visuospatial working memory. Behavioural variables were recorded over 360 consecutive trials in both groups.ResultsBaseline scores of visuospatial working memory did not predict the number of uncertain situations in OCD patients whereas they did in healthy subjects. Uncertain trials led to reduced abilities in visuospatial working memory to 65% of usual performance in OCD patients whereas they remained stable in healthy subjects.ConclusionsThe present findings show an opposite temporal direction in the relationship between abilities in working memory and uncertainty in OCD patients and healthy subjects. Poor working memory performance contributes to the propensity to feel uncertainty in healthy subjects whereas uncertainty contributes to decreased continuous performance in working memory in OCD patients.

Object alternation test—is it sensitive enough to detect cognitive dysfunction in obsessive–compulsive disorder?

2004 ◽  
Vol 19 (7) ◽  
pp. 441-443 ◽  
Author(s):  
Anne Katrin Kuelz ◽  
Dieter Riemann ◽  
Roland Zahn ◽  
Ulrich Voderholzer
Keyword(s):  
Working Memory ◽  
Obsessive Compulsive Disorder ◽  
Cognitive Dysfunction ◽  
Spatial Working Memory ◽  
Healthy Controls ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

AbstractA computerized version of the object alternation test (OAT) was employed in unmedicated obsessive–compulsive disorder (OCD) patients and matched healthy controls. OCD patients performed normally on the OAT but scored below controls on a task assessing visuo-spatial working memory. The results challenge the concept of the OAT as a sensitive instrument for orbitofrontal dysfunction in OCD.

scholarly journals A case-control association study of COMT rs4680 Polymorphism with Obsessive-Compulsive Disorder and Cognitive Functions: The role of sex

2020 ◽  
Author(s):  
sajedeh hamidian ◽  
Abbas Pourshahbaz ◽  
atefeh moradkhani ◽  
Behrooz Dolatshahi ◽  
Esmaeil Shahsavand Ananloo ◽  
...  
Keyword(s):  
Working Memory ◽  
Obsessive Compulsive Disorder ◽  
Cognitive Functions ◽  
Memory Performance ◽  
Total Sample ◽  
Control Group ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Genetic Components

Abstract Background Previous studies have emphasized the role of genetic components in obsessive-compulsive disorder (OCD) and cognitive functions. One of the most controversial markers in this area is the COMT rs4680 polymorphism. In the present study, we aimed to investigate the effect of rs4680 on susceptibility to OCD and cognitive functions with respect to the moderating role of sex. Methods The subjects included 127 patients with OCD and 145 healthy controls. Genotyping was carried out by ARMS-PCR. The subjects underwent cognitive evaluations using the Wechsler Memory Scale-III. Data were analyzed using SPSS 22 and R package software. Results The results showed a significantly higher frequency of the AA genotype in the OCD group than in the healthy control group. Cognitive assessments showed weaker Immediate Memory and General Memory performance in the patients with OCD than in the control group. No significant association was found between rs4680 and memory dimensions in the total sample, whereas analysis by sex revealed a significant association of rs4680 with Working Memory only in females. Conclusions The results of this study confirm previous findings about the association of the AA genotype with OCD. These findings also corroborate previous assumptions about impaired episodic memory in patients with OCD. Moreover, the association of rs4680 with Working Memory only in females endorses the hypothesis of the sexual dimorphism of the effects of this COMT gene polymorphism.

Spatial working memory in obsessive–compulsive disorder improves with clinical response: A functional MRI study

2007 ◽  
Vol 17 (1) ◽  
pp. 16-23 ◽  
Author(s):  
Nic J.A. van der Wee ◽  
Nick F. Ramsey ◽  
Harold J.G.M. van Megen ◽  
Damiaan Denys ◽  
Herman G.M. Westenberg ◽  
...  
Keyword(s):  
Working Memory ◽  
Clinical Response ◽  
Functional Mri ◽  
Obsessive Compulsive Disorder ◽  
Spatial Working Memory ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Mri Study

Reduced efficacy of the spatial working memory system in obsessive compulsive disorder

NeuroImage ◽  
2001 ◽  
Vol 13 (6) ◽  
pp. 1109
Author(s):  
Nic Van der Wee ◽  
Martijn Jansma ◽  
Harold van Megen ◽  
H. Westenberg ◽  
R.S. Kahn ◽  
...  
Keyword(s):  
Working Memory ◽  
Obsessive Compulsive Disorder ◽  
Spatial Working Memory ◽  
Memory System ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

scholarly journals Spatial working memory performance in people with obsessive–compulsive disorder, their unaffected first-degree relatives and healthy controls

BJPsych Open ◽  
2021 ◽  
Vol 7 (6) ◽  
Author(s):  
Stephan Heinzel ◽  
Katharina Bey ◽  
Rosa Grützmann ◽  
Julia Klawohn ◽  
Christian Kaufmann ◽  
...  
Keyword(s):  
Working Memory ◽  
Obsessive Compulsive Disorder ◽  
Spatial Working Memory ◽  
Memory Performance ◽  
Age Effects ◽  
Healthy Controls ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
First Degree Relatives ◽  
Healthy Control

Summary Studies have shown that people with obsessive–compulsive disorder (OCD) have impairments in spatial working memory (SWM) performance. However, it remains unclear whether this deficit represents a cognitive endophenotype preceding symptoms or a correlate of OCD. We investigated SWM in 69 people with OCD, 77 unaffected first-degree relatives of people with OCD and 106 healthy control participants. Taking age effects into account, SWM performance was best in healthy controls, intermediate in relatives and worst in OCD participants. However, since performance did not differ significantly between healthy controls and relatives, our study does not fully support SWM performance as a core cognitive endophenotype of OCD.

Pupil with Obsessive-Compulsive Disorder

2017 ◽  
Vol 7 (2) ◽  
pp. 7-25
Author(s):  
Karolina Diallo
Keyword(s):  
Obsessive Compulsive Disorder ◽  
School Performance ◽  
School Environment ◽  
Detrimental Effect ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
The Past ◽  
And Performance ◽  
The Impact

Pupil with Obsessive-Compulsive Disorder. Over the past twenty years childhood OCD has received more attention than any other anxiety disorder that occurs in the childhood. The increasing interest and research in this area have led to increasing number of diagnoses of OCD in children and adolescents, which affects both specialists and teachers. Depending on the severity of symptoms OCD has a detrimental effect upon child's school performance, which can lead almost to the impossibility to concentrate on school and associated duties. This article is devoted to the obsessive-compulsive disorder and its specifics in children, focusing on the impact of this disorder on behaviour, experience and performance of the child in the school environment. It mentions how important is the role of the teacher in whose class the pupil with this diagnosis is and it points out that it is necessary to increase teachers' competence to identify children with OCD symptoms, to take the disease into the account, to adapt the course of teaching and to introduce such measures that could help children reduce the anxiety and maintain (or increase) the school performance within and in accordance with the school regulations and curriculum.

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