P.030 Loneliness and dependence on central nervous system depressant drugs in older patients

Synthesis of the 4-chlorobenzoylthiourea compound was carried out by acylating thiourea with 4-chlorobenzoyl chloride. The 4-chlorobenzoylthiourea compound will increase the lipophilic and the electronic properties other than the lead compounds of benzoylthiourea in order to, by expectation, raise the central nervous system depressant as well. The lipophilic would affect the ability of the compounds in penetrating biological membranes, which is highly dependent on the solubility of the drug within lipid/water. Log P is the most common method used in determining the parameter value. This experiment was to mix two dissolvents (octanol and water) which are immissible. The both levels of the compounds were carefully observed by a spectrophotometer UV-Vis. From the test, the result of log P value of the 4-chlorobenzoylthiourea compound was 2.32, while the theoretical log P value of the compounds, by using the π Hansch-Fujita method is 1.62 and the f Rekker-Mannhold method is 2.225. Consequently, the result of the test shows that there is a significant difference between the progress experiment and both theoretical log P methods. Moreover, in the test of the central nervous system depressant through the potentiation test to thiopental using mice indicates that the 4-chlorobenzoylthiourea compound have potentiation effects to thiopental compared to the lead compounds of benzoylthiourea.

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Central nervous system active compounds. VI. Reissert compounds as precursors of 1-(3-phthalidy1)isoquinolines

Australian Journal of Chemistry ◽

10.1071/ch9810151 ◽

1981 ◽

Vol 34 (1) ◽

pp. 151 ◽

Cited By ~ 9

Author(s):

TV Hung ◽

BA Mooney ◽

RH Prager ◽

AD Ward

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Phase Transfer ◽

Active Compounds ◽

Central Nervous System Depressant ◽

Reissert Compounds

The reactions of isoquinoline and phthalazine Reissert compounds with phthalaldehydic acids and their derivatives have been investigated as a means of synthesizing 1-(3-phthalidyl)isoquinolines. Of a variety of conditions tried those involving phase transfer were found, in general, to be the most suitable. The products, which are analogues of the convulsant alkaloid bicuculline, showed weak central nervous system depressant activity.

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5-(2-Aminoethyl)-2-oxazolidinones with central nervous system depressant and antiinflammatory activity

Journal of Medicinal Chemistry ◽

10.1021/jm00268a013 ◽

1973 ◽

Vol 16 (10) ◽

pp. 1129-1132 ◽

Cited By ~ 7

Author(s):

William J. Welstead ◽

Grover C. Helsley ◽

C. Roy Taylor ◽

Lennox B. Turnbull ◽

John P. Da Vanzo ◽

...

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Antiinflammatory Activity ◽

Central Nervous System Depressant

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Central nervous system depressant activity of Diospyros peregrina bark

Oriental Pharmacy and Experimental Medicine ◽

10.3742/opem.2004.4.4.249 ◽

2004 ◽

Vol 4 (4) ◽

pp. 249-252 ◽

Cited By ~ 6

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Central Nervous System Depressant

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Lavandulae aetheroleum Oil: A Review on Phytochemical Screening, Medicinal Applications, and Pharmacological Effects

Biointerface Research in Applied Chemistry ◽

10.33263/briac113.98369847 ◽

2020 ◽

Vol 11 (3) ◽

pp. 9836-9847

Keyword(s):

Central Nervous System ◽

Clinical Pharmacology ◽

Nervous System ◽

Chemical Constituents ◽

Cardiovascular Effects ◽

Pharmacological Effects ◽

Lavandula Angustifolia ◽

Experimental Pharmacology ◽

Central Nervous System Depressant ◽

Anti Inflammatory

Lavandulae aetheroleum, the oil, was obtained by vapor condensation from the flower of Lavandula angustifolia Mill. or Lavandula intermedia Loisel (Lamiaceae) plant. Other names of Lavandulae aetheroleum oil are Al birri, common or English lavender. The Lavandula angustifolia Mill. or Lavandula intermedia Loisel plant is spreading in the Mediterranean, southern Europe, Bulgaria, Russia, and USA. The Lavandula angustifolia Mill. or Lavandula intermedia Loisel plant, is an odor shrub with 1-2 m in height. The oil is a clear, colorless, or pale yellow. The gas chromatography studies reported the following percentage of the major chemical constituents in the oil: linalyl acetate (25-46%), linalool (20-45%), terpinen-4-ol (1.2-6.0%), lavendulyl acetate (> 1.0%), 1,8-cineole (1,8-cineol, cineol, cineole, eucalyptol) (< 2.5%), 3-octanone (< 2.5%), camphor (< 1.2%), limonene (< 1.0%), and α-terpineol (< 2.0%). Medicinal applications of the oil include the treatment of restlessness, anxiety, cardiovascular disorders, insomnia, and gastrointestinal disorders, burns, diarrhea, headache, sore throats, and wounds. Pharmacological effects include experimental and clinical pharmacology. Experimental pharmacology includes anesthetic, anticonvulsant, sedative, anti-inflammatory, antimicrobial, antispasmodic, antispasmodic, central nervous system depressant effects. Clinical pharmacology includes anxiolytic, analgesic, and cardiovascular effects. The oil dose by inhalation = 0.06-0.2 ml/ 3 times/day while oil dose internally = 1-4 drops approximately 20-80 mg on a sugar cube per day. In conclusion, Lavandulae aetheroleum oil had an anesthetic, anticonvulsant, sedative, anti-inflammatory, antimicrobial, antispasmodic, antispasmodic, central nervous system depressant, anxiolytic, analgesic, and cardiovascular effects.

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Disorders of cranial nerves

Oxford Textbook of Medicine ◽

10.1093/med/9780199204854.003.2412_update_002 ◽

2010 ◽

pp. 5033-5038

Author(s):

R.D.M. Hadden ◽

P.K. Thomas ◽

R.A.C. Hughes

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Optic Nerve ◽

Older Patients ◽

Cranial Nerves ◽

The Third ◽

Intracavernous Aneurysm ◽

System Tract ◽

Third Nerve ◽

Sixth Nerve

The 12 cranial nerves are peripheral nerves except for the optic nerve which is a central nervous system tract. Disorders of particular note include the following: Olfactory (I) nerve—anosmia is most commonly encountered as a sequel to head injury. Third, fourth, and sixth cranial nerves—complete lesions lead to the following deficits (1) third nerve—a dilated and unreactive pupil, complete ptosis, and loss of upward, downward and medial movement of the eye; (2) fourth nerve—extorsion of the eye when the patient looks outwards, with diplopia when gaze is directed downwards and medially; (3) sixth nerve—convergent strabismus, with inability to abduct the affected eye and diplopia maximal on lateral gaze to the affected side. The third, fourth, and sixth nerves may be affected singly or in combination: in older patients the commonest cause is vascular disease of the nerves themselves or their nuclei in the brainstem. Other causes of lesions include (1) false localizing signs—third or sixth nerve palsies related to displacement of the brainstem produced by supratentorial space-occupying lesions; (2) intracavernous aneurysm of the internal carotid artery—third, fourth, and sixth nerve lesions. Lesions of these nerves can be mimicked by myasthenia gravis....

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