P.0203 Exploring resting-state functional connectivity as a potential predictor of postoperative delirium

2021 ◽  
Vol 53 ◽  
pp. S148-S149
Author(s):  
F. Faro Viana ◽  
M.J. Susano ◽  
G. Cotovio ◽  
J. Oh ◽  
J.E. Shin ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Postoperative Delirium ◽  
Resting State Functional Connectivity ◽  
Potential Predictor

scholarly journals Neurocognitive disorders in the elderly: altered functional resting-state hyperconnectivities in postoperative delirium patients

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jeanne M. Winterer ◽  
Kwaku Ofosu ◽  
Friedrich Borchers ◽  
Daniel Hadzidiakos ◽  
Florian Lammers-Lietz ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Postoperative Delirium ◽  
The Elderly ◽  
Resting State Fmri ◽  
Brain Dysfunction ◽  
Resting State Functional Connectivity ◽  
Time Points ◽  
Network Function ◽  
Compensation Mechanisms

AbstractPostoperative delirium (POD) represents a confusional state during days/weeks after surgery and is particularly frequent in elderly patients. Hardly any fMRI studies were conducted to understand the underlying pathophysiology of POD patients. This prospective observational cohort study aims to examine changes of specific resting-state functional connectivity networks across different time points (pre- and 3–5 months postoperatively) in delirious patients compared to no-POD patients. Two-hundred eighty-three elderly surgical patients underwent preoperative resting-state fMRI (46 POD). One-hundred seventy-eight patients completed postoperative scans (19 POD). For functional connectivity analyses, three functional connectivity networks with seeds located in the orbitofrontal cortex (OFC), nucleus accumbens (NAcc), and hippocampus were investigated. The relationship of POD and connectivity changes between both time points (course connectivity) were examined (ANOVA). Preoperatively, delirious patients displayed hyperconnectivities across the examined functional connectivity networks. In POD patients, connectivities within NAcc and OFC networks demonstrated a decrease in course connectivity [max. F = 9.03, p = 0.003; F = 4.47, p = 0.036, resp.]. The preoperative hyperconnectivity in the three networks in the patients at risk for developing POD could possibly indicate existing compensation mechanisms for subtle brain dysfunction. The observed pathophysiology of network function in POD patients at least partially involves dopaminergic pathways.

Relating Disinhibited Eating Behaviors to Resting State Functional Connectivity in Young Children

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1889-P
Author(s):  
ALLISON L.B. SHAPIRO ◽  
SUSAN L. JOHNSON ◽  
BRIANNE MOHL ◽  
GRETA WILKENING ◽  
KRISTINA T. LEGGET ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Young Children ◽  
Resting State ◽  
Eating Behaviors ◽  
Resting State Functional Connectivity ◽  
Disinhibited Eating

scholarly journals The effect of congenital blindness on resting-state functional connectivity revisited

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Maria J. S. Guerreiro ◽  
Madita Linke ◽  
Sunitha Lingareddy ◽  
Ramesh Kekunnaya ◽  
Brigitte Röder
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Visual Experience ◽  
Brain Regions ◽  
State Condition ◽  
Resting State Functional Connectivity ◽  
Congenital Blindness ◽  
Eyes Closed ◽  
Congenitally Blind ◽  
Eyes Open

AbstractLower resting-state functional connectivity (RSFC) between ‘visual’ and non-‘visual’ neural circuits has been reported as a hallmark of congenital blindness. In sighted individuals, RSFC between visual and non-visual brain regions has been shown to increase during rest with eyes closed relative to rest with eyes open. To determine the role of visual experience on the modulation of RSFC by resting state condition—as well as to evaluate the effect of resting state condition on group differences in RSFC—, we compared RSFC between visual and somatosensory/auditory regions in congenitally blind individuals (n = 9) and sighted participants (n = 9) during eyes open and eyes closed conditions. In the sighted group, we replicated the increase of RSFC between visual and non-visual areas during rest with eyes closed relative to rest with eyes open. This was not the case in the congenitally blind group, resulting in a lower RSFC between ‘visual’ and non-‘visual’ circuits relative to sighted controls only in the eyes closed condition. These results indicate that visual experience is necessary for the modulation of RSFC by resting state condition and highlight the importance of considering whether sighted controls should be tested with eyes open or closed in studies of functional brain reorganization as a consequence of blindness.

scholarly journals Prenatal stress dysregulates resting-state functional connectivity and sensory motifs

2021 ◽  
pp. 100345
Author(s):  
Zahra Rezaei ◽  
Zahra Jafari ◽  
Navvab Afrashteh ◽  
Reza Torabi ◽  
Surjeet Singh ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Prenatal Stress ◽  
Resting State ◽  
Resting State Functional Connectivity

scholarly journals Age-related differences in resting state functional connectivity in pediatric migraine

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Tiffany Bell ◽  
Akashroop Khaira ◽  
Mehak Stokoe ◽  
Megan Webb ◽  
Melanie Noel ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Power Spectra ◽  
Interaction Effects ◽  
Resting State Functional Connectivity ◽  
Default Mode ◽  
Pediatric Migraine ◽  
Age Related ◽  
Status Interaction ◽  
Underlying Mechanisms

Abstract Background Migraine affects roughly 10% of youth aged 5–15 years, however the underlying mechanisms of migraine in youth are poorly understood. Multiple structural and functional alterations have been shown in the brains of adult migraine sufferers. This study aims to investigate the effects of migraine on resting-state functional connectivity during the period of transition from childhood to adolescence, a critical period of brain development and the time when rates of pediatric chronic pain spikes. Methods Using independent component analysis, we compared resting state network spatial maps and power spectra between youth with migraine aged 7–15 and age-matched controls. Statistical comparisons were conducted using a MANCOVA analysis. Results We show (1) group by age interaction effects on connectivity in the visual and salience networks, group by sex interaction effects on connectivity in the default mode network and group by pubertal status interaction effects on connectivity in visual and frontal parietal networks, and (2) relationships between connectivity in the visual networks and the migraine cycle, and age by cycle interaction effects on connectivity in the visual, default mode and sensorimotor networks. Conclusions We demonstrate that brain alterations begin early in youth with migraine and are modulated by development. This highlights the need for further study into the neural mechanisms of migraine in youth specifically, to aid in the development of more effective treatments.

scholarly journals Reduced resting state functional connectivity in the hippocampus-midbrain-striatum network of schizophrenia patients

2021 ◽  
Vol 138 ◽  
pp. 83-88
Author(s):  
Shiral S. Gangadin ◽  
Wiepke Cahn ◽  
Thomas W. Scheewe ◽  
Hilleke E. Hulshoff Pol ◽  
Matthijs G. Bossong
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Resting State Functional Connectivity
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