Sigma-1 receptor stimulation protects retinal ganglion cells from ischemia-like insult through the activation of extracellular-signal-regulated kinases 1/2

2014 ◽  
Vol 128 ◽  
pp. 156-169 ◽  
Author(s):  
Brett H. Mueller ◽  
Yong Park ◽  
Hai-Ying Ma ◽  
Adnan Dibas ◽  
Dorette Z. Ellis ◽  
...  
Keyword(s):  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Retinal Ganglion ◽  
Receptor Stimulation ◽  
Sigma 1 Receptor ◽  
Extracellular Signal ◽  
Sigma 1

scholarly journals Neuroprotection of retinal ganglion cells by the sigma-1 receptor agonist pridopidine in models of experimental glaucoma

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Michal Geva ◽  
Noga Gershoni-Emek ◽  
Luana Naia ◽  
Philip Ly ◽  
Sandra Mota ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Retinal Degeneration ◽  
Retinal Ganglion Cells ◽  
Retinal Ganglion Cell ◽  
Ganglion Cells ◽  
Neuroprotective Effect ◽  
Retinal Ganglion ◽  
Cell Degeneration ◽  
Sigma 1 Receptor ◽  
Sigma 1

AbstractOptic neuropathies such as glaucoma are characterized by retinal ganglion cell (RGC) degeneration and death. The sigma-1 receptor (S1R) is an attractive target for treating optic neuropathies as it is highly expressed in RGCs, and its absence causes retinal degeneration. Activation of the S1R exerts neuroprotective effects in models of retinal degeneration. Pridopidine is a highly selective and potent S1R agonist in clinical development. We show that pridopidine exerts neuroprotection of retinal ganglion cells in two different rat models of glaucoma. Pridopidine strongly binds melanin, which is highly expressed in the retina. This feature of pridopidine has implications to its ocular distribution, bioavailability, and effective dose. Mitochondria dysfunction is a key contributor to retinal ganglion cell degeneration. Pridopidine rescues mitochondrial function via activation of the S1R, providing support for the potential mechanism driving its neuroprotective effect in retinal ganglion cells.

scholarly journals Sigma-1 Receptor Regulates Mitochondrial Function in Glucose- and Oxygen-Deprived Retinal Ganglion Cells

2017 ◽  
Vol 58 (5) ◽  
pp. 2755 ◽  
Author(s):  
Dorette Z. Ellis ◽  
Linya Li ◽  
Yong Park ◽  
Shaoqing He ◽  
Brett Mueller ◽  
...  
Keyword(s):  
Retinal Ganglion Cells ◽  
Mitochondrial Function ◽  
Ganglion Cells ◽  
Retinal Ganglion ◽  
Sigma 1 Receptor ◽  
Sigma 1

scholarly journals Neuroprotection by α2-Adrenergic Receptor Stimulation after Excitotoxic Retinal Injury: A Study of the Total Population of Retinal Ganglion Cells and Their Distribution in the Chicken Retina

PLoS ONE ◽  
2016 ◽  
Vol 11 (9) ◽  
pp. e0161862 ◽  
Author(s):  
Caridad Galindo-Romero ◽  
Mohammad Harun-Or-Rashid ◽  
Manuel Jiménez-López ◽  
Manuel Vidal-Sanz ◽  
Marta Agudo-Barriuso ◽  
...  
Keyword(s):  
Retinal Ganglion Cells ◽  
Adrenergic Receptor ◽  
Total Population ◽  
Ganglion Cells ◽  
Retinal Ganglion ◽  
Receptor Stimulation ◽  
Retinal Injury ◽  
Chicken Retina

Role of Extracellular Signal-Regulated Kinase in Glutamate-Stimulated Apoptosis of Rat Retinal Ganglion Cells

2007 ◽  
Vol 32 (3) ◽  
pp. 233-239 ◽  
Author(s):  
Run-Hai Zhou ◽  
Hong Yan ◽  
Bai-Ren Wang ◽  
Fang Kuang ◽  
Xiao-Li Duan ◽  
...  
Keyword(s):  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Retinal Ganglion ◽  
Extracellular Signal Regulated Kinase ◽  
Extracellular Signal
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