Protective efficacy of a peptide derived from a potential adhesin of Pseudomonas aeruginosa against corneal infection

2016 ◽  
Vol 143 ◽  
pp. 39-48 ◽  
Author(s):  
Qing Yuan ◽  
Yuting Wu ◽  
Yiqiang Wang ◽  
Lin Chen ◽  
Mingli Qu ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Protective Efficacy ◽  
Corneal Infection

scholarly journals Development of Novel Protective Polyvalent Irradiated Pseudomonas aeruginosa Vaccine for Immuno-Compromised Patients

2021 ◽  
Vol 16 ◽  
pp. 1-10
Author(s):  
Manal M.E. Ahmed ◽  
Jakeen Eljakee ◽  
Tarek Mahran
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Protective Efficacy ◽  
Challenge Test ◽  
Opportunistic Pathogen ◽  
Effective Vaccine ◽  
The Novel ◽  
Therapeutic Approaches ◽  
Promising Strategy ◽  
Antigenic Expression ◽  
Compromised Patients

Pseudomonas aeruginosa is an opportunistic pathogen affecting immuno-compromised patients; however, no effective vaccine is currently available in the market. Here, we developed novel polyvalent irradiated P. aeruginosa vaccine using cobalt 60 that inhibited pathogen viability but retained antigenic expression functionally. Mice were vaccinated by the developed vaccine by intranasal, intramuscular and subcutaneous route of administration followed by challenge test. The protective efficacy of the novel vaccine reached up to 95%. This significant protection was mainly associated with measurable antiserum opsonic killing activity. In conclusion, the novel vaccine provides a promising strategy of both prophylactic and therapeutic approaches for immuno-compromised patients against MDR P. aeruginosa.

scholarly journals Draft Genome Sequences of Eight Pseudomonas aeruginosa Corneal Infection Isolates

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Vishnu Raghuram ◽  
Joanna B. Goldberg
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Contact Lens ◽  
Draft Genome ◽  
Ocular Infection ◽  
Bacterial Keratitis ◽  
Genome Sequences ◽  
Content Type ◽  
Corneal Infection

Pseudomonas aeruginosa is the major cause of bacterial keratitis, a sight-threatening ocular infection that can occur in contact lens wearers, as well as in others. Here, we report the draft genomes of 8 different P. aeruginosa corneal isolates, adding to the list of publicly available corneal infection-associated P. aeruginosa genomes.

Phenotype of Pseudomonas aeruginosa Isolates Causing Corneal Infection Between 1997 and 2000

Cornea ◽  
2003 ◽  
Vol 22 (2) ◽  
pp. 131-134 ◽  
Author(s):  
Brigitte A. Cowell ◽  
Barry A. Weissman ◽  
Karen K. Yeung ◽  
Larisa Johnson ◽  
Sharon Ho ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Corneal Infection

Immunogenicity and protective efficacy of Pseudomonas aeruginosa type a and b flagellin vaccines in a burned mouse model

2016 ◽  
Vol 74 ◽  
pp. 71-81 ◽  
Author(s):  
Parisa Laghaei ◽  
Farhad B. Hashemi ◽  
Gholamreza Irajian ◽  
Fatemeh Korpi ◽  
Nour Amirmozafari ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Mouse Model ◽  
Protective Efficacy ◽  
Type A

Pseudomonas aeruginosa corneal infection affects cholinergic enzymes in rat lacrimal gland

2001 ◽  
Vol 177 (1) ◽  
pp. 47-53 ◽  
Author(s):  
Kathleen Dannelly ◽  
Yanwen Liu ◽  
Swapan Ghosh
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Lacrimal Gland ◽  
Corneal Infection

Experimental studies on the protective efficacy of a Pseudomonas aeruginosa vaccine

Vaccine ◽  
1989 ◽  
Vol 7 (6) ◽  
pp. 562-566 ◽  
Author(s):  
E STANISLAVSKY ◽  
L EDVABNAYA ◽  
O BANDMAN ◽  
V BOOLK ◽  
M ZHVANETSKAYA ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Protective Efficacy ◽  
Experimental Studies
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