Analysis of the proteasome activity and the turnover of the serotonin receptor 2B (HTR2B) in human uveal melanoma

2019 ◽  
Vol 184 ◽  
pp. 72-77 ◽  
Author(s):  
Gaëtan Le-Bel ◽  
Manel Benhassine ◽  
Solange Landreville ◽  
Sylvain L. Guérin
Keyword(s):  
Uveal Melanoma ◽  
Serotonin Receptor ◽  
Proteasome Activity ◽  
Serotonin Receptor 2B

Expression of the serotonin receptor 2B in uveal melanoma and effects of an antagonist on cell lines

2018 ◽  
Vol 35 (3) ◽  
pp. 123-134 ◽  
Author(s):  
Cindy Weidmann ◽  
Julie Bérubé ◽  
Léo Piquet ◽  
Arnaud de la Fouchardière ◽  
Solange Landreville
Keyword(s):  
Cell Lines ◽  
Uveal Melanoma ◽  
Serotonin Receptor ◽  
Serotonin Receptor 2B

scholarly journals 176 Serotonin receptor 2b (5-ht2b) modulates cardiomyocyte proliferation by regulating the hippo pathway

Heart ◽  
2017 ◽  
Vol 103 (Suppl 5) ◽  
pp. A122.2-A122 ◽  
Author(s):  
Dowan Kwon ◽  
Yulia Kohar ◽  
Nicholas Stafford ◽  
Delvac Oceandy
Keyword(s):  
Serotonin Receptor ◽  
Hippo Pathway ◽  
Cardiomyocyte Proliferation ◽  
Serotonin Receptor 2B ◽  
The Hippo Pathway

scholarly journals Transcription of the Human 5-Hydroxytryptamine Receptor 2B (HTR2B) Gene Is under the Regulatory Influence of the Transcription Factors NFI and RUNX1 in Human Uveal Melanoma

2018 ◽  
Vol 19 (10) ◽  
pp. 3272 ◽  
Author(s):  
Manel Benhassine ◽  
Sylvain Guérin
Keyword(s):  
Transcription Factors ◽  
Uveal Melanoma ◽  
Serotonin Receptor ◽  
Molecular Mechanisms ◽  
Regulatory Region ◽  
Gene Signature ◽  
Regulatory Elements ◽  
Gene Encoding ◽  
Aberrant Expression ◽  
Factor I

Because it accounts for 70% of all eye cancers, uveal melanoma (UM) is therefore the most common primary ocular malignancy. In this study, we investigated the molecular mechanisms leading to the aberrant expression of the gene encoding the serotonin receptor 2B (HTR2B), one of the most discriminating among the candidates from the class II gene signature, in metastatic and non-metastatic UM cell lines. Transfection analyses revealed that the upstream regulatory region of the HTR2B gene contains a combination of alternative positive and negative regulatory elements functional in HTR2B− but not in HTR23B+ UM cells. We demonstrated that both the transcription factors nuclear factor I (NFI) and Runt-related transcription factor I (RUNX1) interact with regulatory elements from the HTR2B gene to either activate (NFI) or repress (RUNX1) HTR2B expression in UM cells. The results of this study will help understand better the molecular mechanisms accounting for the abnormal expression of the HTR2B gene in uveal melanoma.

scholarly journals A Novel Role of Serotonin Receptor 2B Agonist as an Anti-Melanogenesis Agent

2016 ◽  
Vol 17 (4) ◽  
pp. 546 ◽  
Author(s):  
Eun Oh ◽  
Jong Park ◽  
Ji Lee ◽  
Cheol Myung ◽  
Su Kim ◽  
...  
Keyword(s):  
Serotonin Receptor ◽  
Serotonin Receptor 2B

No Association between a Polymorphism in the Serotonin Receptor 2B (HTR2B) Gene and Personality Traits in Healthy Japanese Subjects

2013 ◽  
Vol 68 (1) ◽  
pp. 59-62 ◽  
Author(s):  
Shoko Tsuchimine ◽  
Takeshi Taniguchi ◽  
Norio Sugawara ◽  
Ayako Kaneda ◽  
Norio Yasui-Furukori
Keyword(s):  
Personality Traits ◽  
Serotonin Receptor ◽  
Serotonin Receptor 2B ◽  
Japanese Subjects

The human serotonin receptor 2B

2004 ◽  
Vol 14 (12) ◽  
pp. 805-811 ◽  
Author(s):  
Zhicheng Lin ◽  
Donna Walther ◽  
Xiao-Ying Yu ◽  
Tomas Drgon ◽  
George R Uhl
Keyword(s):  
Serotonin Receptor ◽  
Serotonin Receptor 2B

scholarly journals Serotonin receptor 2B signaling with interstitial cell activation and leaflet remodeling in degenerative mitral regurgitation

2018 ◽  
Vol 115 ◽  
pp. 94-103 ◽  
Author(s):  
Kathryn H. Driesbaugh ◽  
Emanuela Branchetti ◽  
Juan B. Grau ◽  
Samuel J. Keeney ◽  
Kimberly Glass ◽  
...  
Keyword(s):  
Mitral Regurgitation ◽  
Serotonin Receptor ◽  
Cell Activation ◽  
Interstitial Cell ◽  
Serotonin Receptor 2B

Serotonin Receptor 2B

2012 ◽  
pp. 1726-1726
Author(s):  
Brian R. Dempsey ◽  
Anne C. Rintala-Dempsey ◽  
Gary S. Shaw ◽  
Yuan Xiao Zhu ◽  
A. Keith Stewart ◽  
...  
Keyword(s):  
Serotonin Receptor ◽  
Serotonin Receptor 2B
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