scholarly journals Gene expression and regulation in H2O2-induced premature senescence of human foreskin fibroblasts expressing or not telomerase

2004 ◽  
Vol 39 (9) ◽  
pp. 1379-1389 ◽  
Author(s):  
João Pedro de Magalhães ◽  
Florence Chainiaux ◽  
Françoise de Longueville ◽  
Véronique Mainfroid ◽  
Valérie Migeot ◽  
...  
Keyword(s):  
Gene Expression ◽  
Premature Senescence ◽  
Gene Expression And Regulation ◽  
Human Foreskin Fibroblasts

scholarly journals Transcriptome Analysis of Differentially Expressed mRNA Related to Pigeon Muscle Development

Animals ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 2311
Author(s):  
Hao Ding ◽  
Yueyue Lin ◽  
Tao Zhang ◽  
Lan Chen ◽  
Genxi Zhang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Skeletal Muscle ◽  
Differentially Expressed Genes ◽  
Growth And Development ◽  
Muscle Development ◽  
Expression Patterns ◽  
Differentially Expressed ◽  
Pathway Enrichment Analysis ◽  
Growth Stages ◽  
Gene Expression And Regulation

The mechanisms behind the gene expression and regulation that modulate the development and growth of pigeon skeletal muscle remain largely unknown. In this study, we performed gene expression analysis on skeletal muscle samples at different developmental and growth stages using RNA sequencing (RNA−Seq). The differentially expressed genes (DEGs) were identified using edgeR software. Weighted gene co−expression network analysis (WGCNA) was used to identify the gene modules related to the growth and development of pigeon skeletal muscle based on DEGs. A total of 11,311 DEGs were identified. WGCNA aggregated 11,311 DEGs into 12 modules. Black and brown modules were significantly correlated with the 1st and 10th day of skeletal muscle growth, while turquoise and cyan modules were significantly correlated with the 8th and 13th days of skeletal muscle embryonic development. Four mRNA−mRNA regulatory networks corresponding to the four significant modules were constructed and visualised using Cytoscape software. Twenty candidate mRNAs were identified based on their connectivity degrees in the networks, including Abca8b, TCONS−00004461, VWF, OGDH, TGIF1, DKK3, Gfpt1 and RFC5, etc. A KEGG pathway enrichment analysis showed that many pathways were related to the growth and development of pigeon skeletal muscle, including PI3K/AKT/mTOR, AMPK, FAK, and thyroid hormone pathways. Five differentially expressed genes (LAST2, MYPN, DKK3, B4GALT6 and OGDH) in the network were selected, and their expression patterns were quantified by qRT−PCR. The results were consistent with our sequencing results. These findings could enhance our understanding of the gene expression and regulation in the development and growth of pigeon muscle.

scholarly journals Aquaporin gene expression and regulation in the ovine fetal lung

2003 ◽  
Vol 551 (2) ◽  
pp. 503-514 ◽  
Author(s):  
H. Liu ◽  
S. B. Hooper ◽  
A. Armugam ◽  
N. Dawson ◽  
T. Ferraro ◽  
...  
Keyword(s):  
Gene Expression ◽  
Fetal Lung ◽  
Gene Expression And Regulation ◽  
Aquaporin Gene ◽  
Ovine Fetal

scholarly journals Classification of topological domains based on gene expression and regulation

Genome ◽  
2013 ◽  
Vol 56 (7) ◽  
pp. 415-423 ◽  
Author(s):  
Jingjing Zhao ◽  
Hongbo Shi ◽  
Nadav Ahituv
Keyword(s):  
Gene Expression ◽  
Gene Ontology ◽  
Tissue Type ◽  
Specific Gene ◽  
Gene Expression And Regulation ◽  
Genome Chromosome ◽  
Chromosome Conformation ◽  
Topological Domains ◽  
Tissue Specific ◽  
Mouse Tissues

Tissue-specific gene expression is thought to be one of the major forces shaping mammalian gene order. A recent study that used whole-genome chromosome conformation assays has shown that the mammalian genome is divided into specific topological domains that are shared between different tissues and organisms. Here, we wanted to assess whether gene expression and regulation are involved in shaping these domains and can be used to classify them. We analyzed gene expression and regulation levels in these domains by using RNA-seq and enhancer-associated ChIP-seq datasets for 17 different mouse tissues. We found 162 domains that are active (high gene expression and regulation) in all 17 tissues. These domains are significantly shorter, contain less repeats, and have more housekeeping genes. In contrast, we found 29 domains that are inactive (low gene expression and regulation) in all analyzed tissues and are significantly longer, have more repeats, and gene deserts. Tissue-specific active domains showed some correlation with tissue-type and gene ontology. Domain temporal gene regulation and expression differences also displayed some gene ontology terms fitting their temporal function. Combined, our results provide a catalog of shared and tissue-specific topological domains and suggest that gene expression and regulation could have a role in shaping them.

scholarly journals Transgenic Technology and the Study of Hepatitis Viruses: A Review of What We Have Learned

2000 ◽  
Vol 14 (9) ◽  
pp. 781-787 ◽  
Author(s):  
David R Milich
Keyword(s):  
Gene Expression ◽  
Hepatocellular Carcinoma ◽  
Immune Response ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Transgenic Technology ◽  
Gene Expression And Regulation ◽  
Hepatitis Viruses ◽  
Hbv Replication ◽  
Viral Genes

Because of the absence of inbred animal models susceptible to infection by the hepatitis B (HBV), C (HCV) and delta (HDV) viruses, and the inability to culture these viruses, a number of investigators have produced transgenic (Tg) mice that express one or all the viral genes. This review attempts to catalogue and characterize the Tg mice produced to date. The topics addressed are HBV, HCV and HDV gene expression and regulation; HBV replication models and factors that inhibit replication; HBV pathogenesis models; HBV tolerance and persistence models; modulation of the immune response to HBV proteins in Tg mice; T cell receptor Tg mice; and models of hepatocellular carcinoma.

Gene expression and regulation of N-acetylglucosaminyltransferases III and V in cancer tissues

1998 ◽  
Vol 38 (1) ◽  
pp. 223-232 ◽  
Author(s):  
Naoyuki Taniguchi ◽  
Masafumi Yoshimura ◽  
Eiji Miyoshi ◽  
Yoshito Ihara ◽  
Atsuhi Nishikawa ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Expression And Regulation ◽  
Cancer Tissues

EBV gene expression and regulation

2010 ◽  
pp. 461-489 ◽  
Author(s):  
Lawrence S. Young ◽  
John R. Arrand ◽  
Paul G. Murray
Keyword(s):  
Gene Expression ◽  
Gene Expression And Regulation
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