scholarly journals Glycogen-synthase kinase-3β is decreased in peripheral blood mononuclear cells of patients with mild cognitive impairment

2009 ◽  
Vol 44 (6-7) ◽  
pp. 370-371 ◽  
Author(s):  
Josef Marksteiner ◽  
Christian Humpel
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Glycogen Synthase ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3Β ◽  
Peripheral Blood Mononuclear ◽  
Blood Mononuclear Cells

scholarly journals Adenosine A2AReceptor and IL-10 in Peripheral Blood Mononuclear Cells of Patients with Mild Cognitive Impairment

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Beatrice Arosio ◽  
Luigina Mastronardi ◽  
Cristina Gussago ◽  
Paola Nicolini ◽  
Alessandra Casè ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Cognitive Domain ◽  
Genetic Profile ◽  
Mrna Levels ◽  
Peripheral Blood Mononuclear ◽  
Blood Mononuclear Cells

Adenosine suppresses immune responses through the A2Areceptor (A2AR). This study investigated the interleukin 10 (IL-10) genetic profile and the expression of A2AR in peripheral blood mononuclear cells (PBMCs) of patients with mild cognitive impairment (MCI), Alzheimer disease (AD), and age-matched controls to verify, if they may help distinguish different forms of cognitive decline. We analyzed the IL-10 genotype and the expression of A2AR in 41 subjects with AD, 10 with amnestic MCI (a-MCI), 49 with multiple cognitive domain MCI (mcd-MCI), and 46 controls. There was a significant linear increase in A2AR mRNA levels and A2AR density from mcd-MCI to a-MCI, with intermediate levels being found in AD. The IL-10 AA genotype frequency was 67% in a-MCI, 46% in AD, 35% in mcd-MCI, and 20% in controls. These data suggest that the assessment of the IL-10 genotype and the expression of A2AR in PBMCs may be a valuable means of differentiating between a-MCI and mcd-MCI.

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