Evidence that the Main Adverse Effect of Ganirelix on Pregnancy and Implantation Rates is on the Embryo Rather than the Endometrium

2009 ◽  
Vol 91 (3) ◽  
pp. S19
Author(s):  
M. Press ◽  
J.H. Check ◽  
J. Amui ◽  
J.K. Choe ◽  
D. Brasile
Keyword(s):  
Adverse Effect ◽  
Main Adverse Effect ◽  
Implantation Rates

Experimental studies on seed production of tropical grasses in Kenya. 5. The effect of time of nitrogen top dressing on seed crops of Setaria sphacelata cv. Nandi.

1972 ◽  
Vol 20 (4) ◽  
pp. 225-231
Author(s):  
J.G. Boonman
Keyword(s):  
Adverse Effect ◽  
Seed Production ◽  
Rainy Season ◽  
Seed Set ◽  
Experimental Studies ◽  
Late Season ◽  
Main Adverse Effect ◽  
Setaria Sphacelata ◽  
Seed Crops ◽  
Seed Yields

Effects of date of applying top-dressings of N to early-season and late-season seed crops of Setaria sphacelata cv. Nandi were studied in 4 trials in 1967-71. Highest seed yields were obtained when N was applied as soon as possible after the onset of the rainy season; a delay of 4 weeks reduced yields of pure germinating seed by >60%. Total yields of herbage DM and number of heads were also reduced, but to a lesser extent; the main adverse effect was on seed set/head. In late-season crops, applying N 2 weeks after the earliest possible date proved beneficial in 2 out of 3 years. (Abstract retrieved from CAB Abstracts by CABI’s permission)

scholarly journals Diffuse Alveolar Hemorrhage Associated with Edoxaban Therapy

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Kenichi Nitta ◽  
Hiroshi Imamura ◽  
Akihiro Yashio ◽  
Satoko Kashima ◽  
Katsunori Mochizuki
Keyword(s):  
Adverse Effect ◽  
Major Bleeding ◽  
Serum Levels ◽  
Antineutrophil Cytoplasmic Antibody ◽  
Diffuse Alveolar Hemorrhage ◽  
Alveolar Hemorrhage ◽  
Reversal Agent ◽  
Lower Limb Fractures ◽  
Main Adverse Effect ◽  
Limb Fractures

Introduction. The main adverse effect of anticoagulant therapy is bleeding, and major bleeding, including intracranial, gastrointestinal, and retroperitoneal bleeding, has been reported as an adverse effect of edoxaban, a direct oral anticoagulant (DOAC). Bleeding during systemic anticoagulation with edoxaban presents a therapeutic conundrum, because there is currently no safe or efficacious reversal agent to stop major bleeding. Case Report. A 51-year-old woman had multiple traumatic injuries, including lower limb fractures. On day 8, she developed deep venous thrombosis, and edoxaban was administered orally. On day 38, she developed fungemia, which was treated with an antifungal drug. On day 43, she presented with dyspnea. Chest computed tomography scan showed bilateral diffuse ground-glass opacities in the whole lung fields. The results of the subsequent workup (i.e., serum levels of the antineutrophil cytoplasmic antibody, antinuclear antibody, and antiglomerular basement membrane antibody) and microbiological study were unremarkable. Based on these findings, her condition was diagnosed as diffuse alveolar hemorrhage (DAH) associated with edoxaban therapy. The lung opacities disappeared spontaneously after edoxaban therapy was discontinued. Conclusion. DAH is a dangerous complication associated with edoxaban therapy. DOACs, including edoxaban, should be prescribed with caution, especially for patients in a critical condition.

scholarly journals A RARE COMPLICATION OF BCG IMMUNOTHERAPY

2017 ◽  
Vol 5 ◽  
pp. 1009-1012
Author(s):  
Entela Kolovani ◽  
Ergys Ramosaço ◽  
Rovena Byku ◽  
Najada Çomo ◽  
Rezart Xhani ◽  
...  
Keyword(s):  
Adverse Effect ◽  
Rare Complication ◽  
Effective Agent ◽  
Adequate Treatment ◽  
Bcg Immunotherapy ◽  
Main Adverse Effect ◽  
Superficial Bladder Carcinoma ◽  
Inflammatory Drugs ◽  
Recovery Result ◽  
Reiter Syndrome

Intravesical Bacillus Calmette-Guérin immunotherapy is an effective agent for superficial bladder carcinoma. The main adverse effect of this treatment is cystitis. Arthralgia and migratory arthritis occur only in 0.5% of patients. Reiter syndrome is a very rare complication that can occur after intravesical apply of Bacillus Calmette-Guérin Immunotherapy. We report the first Albanian patient who developed Reiter’s syndrome, following intravesical Bacillus Calmette-Guérin. Diagnose of Reiter’s Syndrome was clinically based, excluding every other reason that could have caused it. Treatment was made with non-steroid and steroid anti-inflammatory drugs, followed by a full recovery result. Even though Reiter's Syndrome is a rare, but significant complication of BCG immunotherapy, it’s important to identify it in time, in order we to offer an adequate treatment.

scholarly journals Perception of the risk of adverse reactions to analgesics: Differences between medical students and residents

2016 ◽  
Author(s):  
Sandra Castillo-Guzman ◽  
Omar González-Santiago ◽  
Ismael A Delgado-Leal ◽  
Gerardo E Lozano-Luévano ◽  
Misael J Reyes-Rodríguez ◽  
...  
Keyword(s):  
Adverse Effect ◽  
Medical Students ◽  
Adverse Effects ◽  
Prescription Drugs ◽  
Adverse Reactions ◽  
Risk Scores ◽  
Gi Bleeding ◽  
Drug Reactions ◽  
Main Adverse Effect ◽  
Prescription Behavior

Background. Medications are not exempt from adverse drug reactions (ADR) and how the physician perceives the risk of prescription drugs could influence their availability to report ADR and their prescription behavior. Methods. We assess the perception of risk and the occurrence of ADR associated with COX2-Inbitors, paracetamol, NSAIDs, and morphine in medical students and residents. Results. The analgesic with the highest risk perception was morphine, while the drug with the least risk perceived was paracetamol. Addiction was perceived as the most probable adverse effects developed by morphine. In the case of NSAIDs, the main adverse effect perceived was GI bleeding. Discussion. Our findings show that medical students give higher risk scores than residents toward risk due to analgesics. It is probable that both groups of students have morphinophobia, although more studies are necessary to confirm this. Continuing training and informing physicians about ADRs is necessary since the lack of training is known to induce inadequate use of drugs.

scholarly journals Perception of the risk of adverse reactions to analgesics: Differences between medical students and residents

2016 ◽  
Author(s):  
Sandra Castillo-Guzman ◽  
Omar González-Santiago ◽  
Ismael A Delgado-Leal ◽  
Gerardo E Lozano-Luévano ◽  
Misael J Reyes-Rodríguez ◽  
...  
Keyword(s):  
Adverse Effect ◽  
Medical Students ◽  
Adverse Effects ◽  
Prescription Drugs ◽  
Adverse Reactions ◽  
Risk Scores ◽  
Gi Bleeding ◽  
Drug Reactions ◽  
Main Adverse Effect ◽  
Prescription Behavior

Background. Medications are not exempt from adverse drug reactions (ADR) and how the physician perceives the risk of prescription drugs could influence their availability to report ADR and their prescription behavior. Methods. We assess the perception of risk and the occurrence of ADR associated with COX2-Inbitors, paracetamol, NSAIDs, and morphine in medical students and residents. Results. The analgesic with the highest risk perception was morphine, while the drug with the least risk perceived was paracetamol. Addiction was perceived as the most probable adverse effects developed by morphine. In the case of NSAIDs, the main adverse effect perceived was GI bleeding. Discussion. Our findings show that medical students give higher risk scores than residents toward risk due to analgesics. It is probable that both groups of students have morphinophobia, although more studies are necessary to confirm this. Continuing training and informing physicians about ADRs is necessary since the lack of training is known to induce inadequate use of drugs.

scholarly journals DaraRD in systemic AL amyloidosis: high efficacy, relevant toxicity and main adverse effect of gain 1q21

2021 ◽  
Author(s):  
Christoph R. Kimmich ◽  
Tobias Terzer ◽  
Axel Benner ◽  
Timon Hansen ◽  
Alexander Carpinteiro ◽  
...  
Keyword(s):  
Adverse Effect ◽  
Al Amyloidosis ◽  
High Efficacy ◽  
Main Adverse Effect

scholarly journals Modelling primaquine-induced haemolysis in G6PD deficiency

eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
James Watson ◽  
Walter RJ Taylor ◽  
Didier Menard ◽  
Sim Kheng ◽  
Nicholas J White
Keyword(s):  
Adverse Effect ◽  
Blood Cell ◽  
Compartmental Model ◽  
Dehydrogenase Deficiency ◽  
Published Data ◽  
Radical Cure ◽  
Main Adverse Effect ◽  
Glucose 6 Phosphate Dehydrogenase ◽  
Dose Dependent ◽  
Erythrocyte Age

Primaquine is the only drug available to prevent relapse in vivax malaria. The main adverse effect of primaquine is erythrocyte age and dose-dependent acute haemolytic anaemia in individuals with glucose-6-phosphate dehydrogenase deficiency (G6PDd). As testing for G6PDd is often unavailable, this limits the use of primaquine for radical cure. A compartmental model of the dynamics of red blood cell production and destruction was designed to characterise primaquine-induced haemolysis using a holistic Bayesian analysis of all published data and was used to predict a safer alternative to the currently recommended once weekly 0.75 mg/kg regimen for G6PDd. The model suggests that a step-wise increase in daily administered primaquine dose would be relatively safe in G6PDd. If this is confirmed, then were this regimen to be recommended for radical cure patients would not require testing for G6PDd in areas where G6PDd Viangchan or milder variants are prevalent.

The Resolution and Contrast in Biological Sections Determined by Inelastic and Elastic Scattering

1973 ◽  
Vol 31 ◽  
pp. 224-225
Author(s):  
D. L. Misell
Keyword(s):  
Electron Microscopy ◽  
Adverse Effect ◽  
Elastic Scattering ◽  
Inelastic Scattering ◽  
Amorphous Carbon ◽  
Polymeric Materials ◽  
Chromatic Aberration ◽  
Image Resolution ◽  
Quantitative Estimates ◽  
Elastic Ratio

In the electron microscopy of biological sections the adverse effect of chromatic aberration on image resolution is well known. In this paper calculations are presented for the inelastic and elastic image intensities using a wave-optical formulation. Quantitative estimates of the deterioration in image resolution as a result of chromatic aberration are presented as an alternative to geometric calculations. The predominance of inelastic scattering in the unstained biological and polymeric materials is shown by the inelastic to elastic ratio, I/E, within an objective aperture of 0.005 rad for amorphous carbon of a thickness, t=50nm, typical of biological sections; E=200keV, I/E=16.

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