scholarly journals MALE FACTOR INFERTILITY AND ADVANCED PATERNAL AGE ARE CHARACTERIZED BY UNIQUE SPERM EPIGENOMES

2021 ◽  
Vol 116 (3) ◽  
pp. e330
Author(s):  
Michelle M. Denomme Tignanelli ◽  
Mary E. Haywood ◽  
William B. Schoolcraft ◽  
Mandy G. Katz-Jaffe
Keyword(s):  
Paternal Age ◽  
Male Factor Infertility ◽  
Male Factor ◽  
Advanced Paternal Age

scholarly journals Recent advances in understanding and managing male infertility

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 670 ◽  
Author(s):  
Jonathan Fainberg ◽  
James A. Kashanian
Keyword(s):  
Male Infertility ◽  
Paternal Age ◽  
World Health ◽  
Testicular Sperm Extraction ◽  
Male Factor Infertility ◽  
Male Factor ◽  
Lifestyle Choices ◽  
Health Organization ◽  
Shed Light

Infertility is a prevalent condition affecting an estimated 70 million people globally. The World Health Organization estimates that 9% of couples worldwide struggle with fertility issues and that male factor contributes to 50% of the issues. Male infertility has a variety of causes, ranging from genetic mutations to lifestyle choices to medical illnesses or medications. Recent studies examining DNA fragmentation, capacitation, and advanced paternal age have shed light on previously unknown topics. The role of conventional male reproductive surgeries aimed at improving or addressing male factor infertility, such as varicocelectomy and testicular sperm extraction, have recently been studied in an attempt to expand their narrow indications. Despite advances in the understanding of male infertility, idiopathic sperm abnormalities still account for about 30% of male infertility. With current and future efforts examining the molecular and genetic factors responsible for spermatogenesis and fertilization, we may be better able to understand etiologies of male factor infertility and thus improve outcomes for our patients.

scholarly journals REPRODUCTIVE OUTCOMES OF COUPLES WITH SEVERE MALE FACTOR AND ADVANCED PATERNAL AGE

2020 ◽  
Vol 114 (3) ◽  
pp. e377-e378
Author(s):  
Krishna Mantravadi ◽  
Gayathri Gedela ◽  
Vijay Kumar Sharanappa ◽  
Shankhadeep Debnath ◽  
Rajesh Mani Raghupathy ◽  
...  
Keyword(s):  
Paternal Age ◽  
Reproductive Outcomes ◽  
Male Factor ◽  
Advanced Paternal Age

scholarly journals ASSOCIATION BETWEEN PATERNAL AGE, MALE FACTOR INFERTILITY, AND EUPLOIDY RATE AMONG DONOR EGG CYCLES

2021 ◽  
Vol 116 (1) ◽  
pp. e27
Author(s):  
Karmon Anatte Emma ◽  
Ohta Tamara Tomomi ◽  
Frattarelli John Leslie
Keyword(s):  
Paternal Age ◽  
Male Factor Infertility ◽  
Male Factor ◽  
Donor Egg ◽  
Euploidy Rate

scholarly journals Male factor infertility or paternal age are not associated with embryo aneuploidy

2018 ◽  
Vol 110 (4) ◽  
pp. e293
Author(s):  
J.M. Morris ◽  
S.L. Bristow ◽  
M.E. Rausch ◽  
Y.G. Kramer ◽  
C. McCaffrey ◽  
...  
Keyword(s):  
Paternal Age ◽  
Male Factor Infertility ◽  
Male Factor

Men's perception and understanding of male-factor infertility in the UK

2021 ◽  
Vol 30 (9) ◽  
pp. S8-S16
Author(s):  
Eleanor L Stevenson ◽  
Cheng Ching-Yu ◽  
Chang Chia-Hao ◽  
Kevin R McEleny
Keyword(s):  
Public Health ◽  
Emotional Support ◽  
Health Professionals ◽  
Male Fertility ◽  
Public Knowledge ◽  
Evidence Based ◽  
Male Factor Infertility ◽  
Male Factor ◽  
The Public ◽  
The Uk

Male-factor infertility is a common but stigmatised issue, and men often do not receive the emotional support and the information they need. This study sought to understand awareness of male fertility issues compared to female fertility among the UK general male public, and also what were perceived as being the optimum methods for providing support for affected men, emotionally and through information. Men feel that male infertility is not discussed by the public as much as female infertility. Lifestyle issues that affect male fertility are not well understood, and men affected by infertility desire more support, including online, from health professionals and through peer support. Health professionals, including those in public health, could offer evidence-based programmes to reduce stigma and increase public knowledge about infertility, as well as offer emotional support to men with infertility problems.

scholarly journals Controlled ovarian stimulation should not be preferred for male infertility treated with intrauterine insemination: a retrospective study

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Yan Tang ◽  
Qian-Dong He ◽  
Ting-Ting Zhang ◽  
Jing-Jing Wang ◽  
Si-Chong Huang ◽  
...  
Keyword(s):  
Ectopic Pregnancy ◽  
Pregnancy Rate ◽  
Ovarian Stimulation ◽  
Intrauterine Insemination ◽  
Multiple Pregnancy ◽  
Clinical Pregnancy ◽  
Male Factor Infertility ◽  
Male Factor ◽  
Ovulatory Follicles ◽  
Multiple Pregnancy Rate

Abstract Background Some studies have stated that intrauterine insemination (IUI) with controlled ovarian stimulation (COS) might increase the pregnancy rate, while others suggest that IUI in the natural cycle (NC) should be the first line of treatment. It remains unclear whether it is necessary to use COS at the same time when IUI is applied to treat isolated male factor infertility. Thus, we aimed to investigate efficacy of IUI with COS for isolated male factor infertility. Methods A total of 601 IUI cycles from 307 couples who sought medical care for isolated male factor infertility between January 2010 and February 2020 were divided into two groups: NC-IUI and COS-IUI. The COS-IUI group was further divided into two subgroups according to the number of pre-ovulatory follicles on the day of HCG: cycles with monofollicular development (one follicle group) and cycles with at least two pre-ovulatory follicles (≥ 2 follicles group). The IUI outcomes, including clinical pregnancy, live birth, spontaneous abortion, ectopic pregnancy, and multiple pregnancy rates were compared. Results The clinical pregnancy, live birth, spontaneous abortion, and ectopic pregnancy rates were comparable between the NC-IUI and COS-IUI group. Similar results were also observed among the NC-IUI, one follicle, and ≥ 2 follicles groups. However, with respect to the multiple pregnancy rate, a trend toward higher multiple pregnancy rate was observed in the COS-IUI group compared to the NC-IUI group (8.7% vs. 0, P = 0.091), and a significant difference was found between the NC-IUI and ≥ 2 follicles group (0 vs. 16.7%, P = 0.033). Conclusion In COS cycles, especially in those with at least two pre-ovulatory follicles, the multiple pregnancy rate increased without a substantial gain in overall pregnancy rate; thus, COS should not be preferred in IUI for isolated male factor infertility. If COS is required, one stimulated follicle and one healthy baby should be the goal considering the safety of both mothers and foetuses.

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