Functional analysis of the selective autophagy related gene Acatg11 in Acremonium chrysogenum

Aim: To investigate the autophagy-related gene (ATG) expression and the associated noncoding RNAs (ncRNA) and transcription factors (TF) in digestive system tumors (DST). Methods: We systematically investigated the ATG expression in DST by weighted gene correlation network analysis, crosstalk connection, functional analysis and Pivot analysis. Results: ATGs were clustered into six modules with co-expression in DST. Functional analysis revealed that six ATG-related modules were enriched in biological pathways involved in tumorigenesis. Pivot analysis identified key ncRNAs and TFs, which are essential for the pathogenesis, clinical diagnosis and treatment of DST. Conclusion: Our study highlights the crucial roles of ncRNA and TFs in the identification of potential biomarkers or therapeutic targets for DST.

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Functional analysis of the latency-related gene of bovine herpesvirus types 1 and 5

Journal of NeuroVirology ◽

10.1007/s13365-019-00745-y ◽

2019 ◽

Vol 25 (4) ◽

pp. 597-604 ◽

Cited By ~ 1

Author(s):

Carolina Silvestro ◽

Clinton Jones ◽

Ana Bratanich

Keyword(s):

Functional Analysis ◽

Bovine Herpesvirus ◽

Related Gene

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Emerging Roles of the Selective Autophagy in Plant Immunity and Stress Tolerance

International Journal of Molecular Sciences ◽

10.3390/ijms21176321 ◽

2020 ◽

Vol 21 (17) ◽

pp. 6321

Author(s):

Jie Ran ◽

Sayed M. Hashimi ◽

Jian-Zhong Liu

Keyword(s):

Abiotic Stress ◽

Stress Tolerance ◽

Plant Immunity ◽

Abiotic Stress Tolerance ◽

Ubiquitin Proteasome System ◽

Biological Processes ◽

Related Gene ◽

Biotic And Abiotic Stress ◽

Selective Autophagy ◽

Ubiquitin Proteasome

Autophagy is a conserved recycling system required for cellular homeostasis. Identifications of diverse selective receptors/adaptors that recruit appropriate autophagic cargoes have revealed critical roles of selective autophagy in different biological processes in plants. In this review, we summarize the emerging roles of selective autophagy in both biotic and abiotic stress tolerance and highlight the new features of selective receptors/adaptors and their interactions with both the cargoes and Autophagy-related gene 8s (ATG8s). In addition, we review how the two major degradation systems, namely the ubiquitin–proteasome system (UPS) and selective autophagy, are coordinated to cope with stress in plants. We especially emphasize how plants develop the selective autophagy as a weapon to fight against pathogens and how adapted pathogens have evolved the strategies to counter and/or subvert the immunity mediated by selective autophagy.

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