Coinfection of domestic felines by distinct Sporothrix brasiliensis in the Brazilian sporotrichosis hyperendemic area

Sporotrichosis is a dermatozoonosis, caused by dimorphic pathogenic fungi of the genus Sporothrix. Although Sporothrix brasiliensis is the most frequent and pathogenic species identified from the Brazilian sporotrichosis hyperendemic, to the best of our knowledge this is the first report of its molecular diagnosis from a cat with ocular lesions. A 3-month old female, domestic feline presented an ocular manifestation with granuloma in the lower-left palpebral conjunctiva, in addition to mucocutaneous lesions in varied locations throughout the body. Samples were collected for subsequent cytopathology, fungal culture, serology, and molecular genotyping. Itraconazole was prescribed for the treatment of sporotrichosis and the animal was considered clinically cured at the end of 5 months of treatment and discharged. S. brasiliensis cat interactions can manifest with a multitude of clinical forms that resemble either infectious or noninfectious diseases. Both the need for meticulous cat physical evaluation by a veterinarian followed by accurate laboratory diagnosis are key Public Health measures in the Brazilian sporotrichosis hyperendemic area.

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Synthesis and Antifungal Activity of Coumarins Derivatives Against Sporothrix spp.

Current Topics in Medicinal Chemistry ◽

10.2174/1568026618666180221115508 ◽

2018 ◽

Vol 18 (2) ◽

pp. 164-171 ◽

Cited By ~ 4

Author(s):

Luana da S.M. Forezi ◽

Luana Pereira Borba-Santos ◽

Mariana F.C. Cardoso ◽

Vitor F. Ferreira ◽

Sonia Rozental ◽

...

Keyword(s):

Antifungal Activity ◽

Antifungal Agents ◽

Sporothrix Schenckii ◽

Public Health Problem ◽

Domestic Animals ◽

Coumarin Derivatives ◽

Sporothrix Brasiliensis ◽

Synthetic Routes ◽

Effective Drugs

Sporotrichosis is a serious public health problem in Brazil that affects human patients and domestic animals, mainly cats. Thus, the search for new antifungal agents is required also due to the emergence and to the lack of effective drugs available in the therapeutic arsenal. The aim of this study was to evaluate the in vitro antifungal profile of two synthetic series of coumarin derivatives against Sporothrix schenckii and Sporothrix brasiliensis. The three-components synthetic routes used for the preparation of coumarin derivatives have proved to be quite efficient and compounds 16 and 17 have been prepared in good yields. The inhibitory activity of nineteen synthetic coumarins derivatives 16a-i and 17a-j were evaluated against Sporothrix spp. yeasts and the most potent compounds were 16b and 17i. However, according to concentrations able to inhibit (minimum inhibitory concentrations) and kill (minimum fungicidal concentrations) the cells, 17i was more effective than 16b against Sporothrix spp. Thus, 17i exhibited good antifungal activity against S. brasiliensis and S. schenckii, suggesting that it is an important scaffold for the development of novel antifungal agents.

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Human Sporotrichosis Outbreak caused by Sporothrix brasiliensis in a Veterinary Hospital in Southern Brazil

Journal de Mycologie Médicale ◽

10.1016/j.mycmed.2021.101163 ◽

2021 ◽

pp. 101163

Author(s):

José Raphael Batista Xavier ◽

Stefanie Bressan Waller ◽

Luíza da Gama Osório ◽

Patrícia Silva Vives ◽

Ana Paula Neuschrank Albano ◽

...

Keyword(s):

Southern Brazil ◽

Sporothrix Brasiliensis ◽

Veterinary Hospital

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SÍNDROME OCULOGLANDULAR DE PARINAUD COM CULTURA POSITIVA PARA SPOROTHRIX BRASILIENSIS

The Brazilian Journal of Infectious Diseases ◽

10.1016/j.bjid.2020.101444 ◽

2021 ◽

Vol 25 ◽

pp. 101444

Author(s):

Amanda Silva Guimarães ◽

Hugo Pessotti Aborghetti ◽

Bruno Oggioni Moura ◽

Luciana Catelan ◽

Pedro Gabriel Coffler Zorzal ◽

...

Keyword(s):

Sporothrix Brasiliensis

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Palate ulcer, uvular destruction and nasal septal perforation caused by Sporothrix brasiliensis in an HIV-infected patient

Medical Mycology Case Reports ◽

10.1016/j.mmcr.2018.11.001 ◽

2019 ◽

Vol 23 ◽

pp. 16-19 ◽

Cited By ~ 2

Author(s):

Walter A. Eyer-Silva ◽

Marcelo Costa Velho Mendes de Azevedo ◽

Guilherme Almeida Rosa da Silva ◽

Rodrigo Panno Basílio-de-Oliveira ◽

Luciana Ferreira de Araujo ◽

...

Keyword(s):

Infected Patient ◽

Septal Perforation ◽

Sporothrix Brasiliensis ◽

Nasal Septal Perforation

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In vitro susceptibility of the Sporothrix brasiliensis to aqueous extracts of the green tea (Camellia sinensis L. Kuntze)

Acta Veterinaria Brasilica ◽

10.21708/avb.2015.9.4.5414 ◽

2016 ◽

Vol 9 (4) ◽

Keyword(s):

Green Tea ◽

Camellia Sinensis ◽

Aqueous Extracts ◽

In Vitro Susceptibility ◽

Sporothrix Brasiliensis

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Prolonged Co-circulation of Two Distinct Dengue Virus Type 3 Lineages in the Hyperendemic Area of Medellín, Colombia

American Journal of Tropical Medicine and Hygiene ◽

10.4269/ajtmh.2010.09-0766 ◽

2010 ◽

Vol 83 (3) ◽

pp. 672-678 ◽

Cited By ~ 13

Author(s):

Marta C. Ospina ◽

Francisco J. Diaz ◽

Jorge E. Osorio

Keyword(s):

Dengue Virus ◽

Virus Type ◽

Hyperendemic Area ◽

Dengue Virus Type 3 ◽

Type 3

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Synthetic Derivatives against Wild-Type and Non-Wild-Type Sporothrix brasiliensis: In Vitro and In Silico Analyses

Pharmaceuticals ◽

10.3390/ph15010055 ◽

2022 ◽

Vol 15 (1) ◽

pp. 55

Author(s):

Lais Cavalcanti dos Santos Velasco de Souza ◽

Lucas Martins Alcântara ◽

Pãmella Antunes de Macêdo-Sales ◽

Nathália Faria Reis ◽

Débora Sena de Oliveira ◽

...

Keyword(s):

In Silico ◽

Wide Distribution ◽

Wild Type ◽

Sporothrix Brasiliensis ◽

Microdilution Method ◽

Broth Microdilution Method ◽

Therapeutic Alternatives ◽

Synthetic Derivatives ◽

Prevalent Species

Recently, the well-known geographically wide distribution of sporotrichosis in Brazil, combined with the difficulties of effective domestic feline treatment, has emphasized the pressing need for new therapeutic alternatives. This work considers a range of synthetic derivatives as potential antifungals against Sporothrix brasiliensis isolated from cats from the hyperendemic Brazilian region. Six S. brasiliensis isolates from the sporotrichotic lesions of itraconazole responsive or non-responsive domestic cats were studied. The minimum inhibitory concentrations (MICs) of three novel hydrazone derivatives and eleven novel quinone derivatives were determined using the broth microdilution method (M38-A2). In silico tests were also used to predict the pharmacological profile and toxicity parameters of these synthetic derivatives. MICs and MFCs ranged from 1 to >128 µg/mL. The ADMET computational analysis failed to detect toxicity while a good pharmacological predictive profile, with parameters similar to itraconazole, was obtained. Three hydrazone derivatives were particularly promising candidates as antifungal agents against itraconazole-resistant S. brasiliensis from the Brazilian hyperendemic region. Since sporotrichosis is a neglected zoonosis currently spreading in Latin America, particularly in Brazil, the present data can contribute to its future control by alternative antifungal drug design against S. brasiliensis, the most virulent and prevalent species of the hyperendemic context.

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