Five 11α, 12α-epoxy pentacyclic triterpenoid saponins with antithrombus activities from Glechoma longituba

Fitoterapia ◽  
2019 ◽  
Vol 138 ◽  
pp. 104345 ◽  
Author(s):  
Xi-Lin Ouyang ◽  
Wen-Hua Mao ◽  
Chun-Gu Wang ◽  
Ying-Ming Pan ◽  
Dong Liang ◽  
...  
Keyword(s):  
Triterpenoid Saponins ◽  
Pentacyclic Triterpenoid ◽  
Glechoma Longituba

Acetylated rhamnose triterpenoid saponins from Glechoma longituba analyzed by LC‐Q‐TOFMS

2021 ◽  
Author(s):  
Xi-Lin Ouyang ◽  
Tian-Hua Ma ◽  
Gui-Liang Xie ◽  
Shan Chen ◽  
Heng-Shan Wang ◽  
...  
Keyword(s):  
Triterpenoid Saponins ◽  
Glechoma Longituba

Pentacyclic Triterpenoid Saponins from Silene viscidula

2010 ◽  
Vol 93 (10) ◽  
pp. 2007-2014 ◽  
Author(s):  
Wei Xu ◽  
Jia-Mei Wu ◽  
Zheng Zhu ◽  
Yi Sha ◽  
Jin Fang ◽  
...  
Keyword(s):  
Triterpenoid Saponins ◽  
Pentacyclic Triterpenoid

scholarly journals Comparative Metabolomics of Reproductive Organs in the Genus Aesculus (Sapindaceae) Reveals That Immature Fruits Are a Key Organ of Procyanidin Accumulation and Bioactivity

Plants ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 2695
Author(s):  
Alison Green ◽  
Guillermo Federico Padilla-Gonzalez ◽  
Methee Phumthum ◽  
Monique S. J. Simmonds ◽  
Nicholas J. Sadgrove
Keyword(s):  
Principal Component ◽  
Reproductive Organs ◽  
Antioxidant Compounds ◽  
Isomeric Mixture ◽  
Triterpenoid Saponins ◽  
Flavonoid Aglycones ◽  
Pentacyclic Triterpenoid ◽  
Liquid Chromatography Tandem Mass ◽  
Organ Specific ◽  
Chemical Profiles

Fruit from A. hippocastanum L. are used commercially for chronic venous insufficiency (CVI). The isomeric mixture of pentacyclic triterpenoid saponins (β-aescin) exert anti-inflammatory effects. Hence, research has focused on β-aescin, yet the diversity, accumulation, and bioactivity of organ-specific secondary metabolites represent missed pharmacological opportunities. To this end, we applied an untargeted metabolomics approach by liquid chromatography—tandem mass spectrometry (LC–MS/MS) to the chemical profiles of flowers, immature fruits, and pedicels from 40 specimens across 18 species of Aesculus. Principal component analysis (PCA), orthogonal partial least squares (OPLS-DA), and molecular networking revealed stronger chemical differences between plant organs, than between species. Flowers are rich in glycosylated flavonoids, pedicels in organic acids and flavonoid aglycones, and immature fruits in monomeric flavan-3-ols and procyanidins. Although a high diversity of flavonoids and procyanidins was observed, the relative amounts differed by plant organ. Fruit extracts demonstrated the strongest antifungal (Saccharomyces cerevisiae) and antioxidant activity, likely from the procyanidins. Overall, secondary metabolite profiles are organ-specific, and fruits accumulate antifungal and antioxidant compounds. Due to the chemical similarity between species, similar effects may be achieved between species. This creates incentives for further exploration of the entire genus, in bioprospecting for potential therapeutic leads.

Two new oleanane-type pentacyclic triterpenoid saponins from the husks ofXanthoceras sorbifoliaBunge

2012 ◽  
Vol 14 (3) ◽  
pp. 216-223 ◽  
Author(s):  
Hao Cui ◽  
Hang Xiao ◽  
Xiao-Ku Ran ◽  
Ying-Ying Li ◽  
De-Qiang Dou ◽  
...  
Keyword(s):  
Triterpenoid Saponins ◽  
Pentacyclic Triterpenoid

scholarly journals Regioselective Hydroxylation of Oleanolic Acid Catalyzed by Human CYP3A4 to Produce Hederagenenin, a Chiral Metabolite

Catalysts ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 267
Author(s):  
Ngoc Tan Cao ◽  
Ngoc Anh Nguyen ◽  
Thien-Kim Le ◽  
Gun Su Cha ◽  
Ki Deok Park ◽  
...  
Keyword(s):  
Oleanolic Acid ◽  
Free Acid ◽  
Efficacy And Safety ◽  
Oxidation Reactions ◽  
Triterpenoid Saponins ◽  
Pentacyclic Triterpenoid ◽  
C 23 ◽  
Regioselective Hydroxylation ◽  
Acid Catalyzed ◽  
Catalyzed Oxidation

Oleanolic acid (OA) is a pentacyclic triterpenoid widely found in plants and foods as an aglycone of triterpenoid saponins or as a free acid. OA exhibits beneficial activities for humans, including antitumor, antivirus, and hepatoprotection properties without apparent toxicity. The metabolites produced by the cytochrome P450 (P450) enzymes are critical for the evaluation of the efficacy and safety of drugs. In this study, the potential metabolites of OA were investigated by P450-catalyzed oxidation reactions. Among the various tested human P450s, only human CYP3A4 was active for the hydroxylation of OA. The major metabolite was characterized by a set of analyses using HPLC, LC–MS, and NMR. It was found to be 4-epi-hederagenenin, a chiral product, by regioselective hydroxylation of the methyl group at the C-23 position. These results indicated that CYP3A4 can hydroxylate an OA substrate to make 4-epi-hederagenenin. Possible drug–food interactions are discussed.

scholarly journals Pharmacological Review on Asiatic Acid and Its Derivatives: A Potential Compound

2018 ◽  
Vol 23 (2) ◽  
pp. 111-127 ◽  
Author(s):  
Junwei Lv ◽  
Alok Sharma ◽  
Ting Zhang ◽  
Yuchen Wu ◽  
Xianting Ding
Keyword(s):  
Intracellular Signaling ◽  
Molecular Mechanisms ◽  
Biological Activities ◽  
Research Work ◽  
Centella Asiatica ◽  
Asiatic Acid ◽  
Pharmacological Properties ◽  
Triterpenoid Saponins ◽  
Pentacyclic Triterpenoid ◽  
Pharmacologically Active

Natural triterpenes represent a group of pharmacologically active and structurally diverse organic compounds. The focus on these phytochemicals has been enormous in the past few years, worldwide. Asiatic acid (AA), a naturally occurring pentacyclic triterpenoid, is found mainly in the traditional medicinal herb Centella asiatica. Triterpenoid saponins, which are the primary constituents of C. asiatica, are commonly believed to be responsible for their extensive therapeutic actions. Published research work has described the molecular mechanisms underlying the various biological activities of AA and its derivatives, which vary for each chronic disease. However, a compilation of the various pharmacological properties of AA has not yet been done. Herein, we describe in detail the pharmacological properties of AA and its derivatives that inhibit multiple pathways of intracellular signaling molecules and transcription factors that are involved in the various stages of chronic diseases. Furthermore, the pharmacological activities of AA were compared with two natural compounds: curcumin and resveratrol. This review summarizes the research on AA and its derivatives and helps to provide future directions in the area of drug development.

scholarly journals Determination of The Active Asiaticoside Content in Centella asiatica as Anti-Cellulite Agent

2011 ◽  
Vol 2 (2) ◽  
pp. 222 ◽  
Author(s):  
Dewi Sondari ◽  
Sri Budi Harmami ◽  
M. Ghozali ◽  
Ahmad Randy ◽  
Athanasia Amanda S. ◽  
...  
Keyword(s):  
High Performance ◽  
Wide Spectrum ◽  
Ethanolic Extract ◽  
Centella Asiatica ◽  
Pharmacological Activities ◽  
Triterpenoid Saponins ◽  
Pentacyclic Triterpenoid ◽  
Significant Difference ◽  
Layer Chromatography

Centella asiatica accumulates large quantities of pentacyclic triterpenoid saponins, collectively known as centelloids. These terpenoids include asiaticoside, centelloside, madecassoside, brahmoside, brahminoside, thankuniside, sceffoleoside, centellose, asiatic-, brahmic-, centellic- and madecassic acids. Preparations of C. asiatica are used in traditional and alternative medicine due to the wide spectrum of pharmacological activities associated with these secondary metabolites, such as anticellulite agent. Asiaticoside was found in Centella asiatica. In this present study, the asiaticoside was extracted using methanolic and ethanolic solvent. Determination of the asiaticoside content in the extract was conducted with High Performance Liquid Chromatography (HPLC), Thin Layer Chromatography (TLC), and Fourier Transform Infra Red (FTIR). Samples of C. asiatica used in this study came from three different plantation areas, Bogor, Lembang and Solo. Asiaticoside content in the methanolic extract from Bogor, Lembang, and Solo samples were 2.82%; 2.68%; and 2.8% respectively. Asiaticoside in ethanolic extract from Bogor, Lembang, and Solo samples were 2.79%; 2.75%; and 2.91% respectively. Two way ANOVA study showed that there was significant difference between types of solvent used in extraction and the asiaticoside content in the obtained extract, significant difference between varied plantation area and obtained asiaticoside content, and significant difference between interactions of different solvent with different plantation area.  Keywords: Centella asiatica, asiaticoside, anticellulite, medicine, metabolites       

Five New Oleanane Triterpenoid Saponins from the Aerial Parts ofElsholtzia bodinieri

2016 ◽  
pp. n/a-n/a
Author(s):  
Jin-Dong Zhong ◽  
Xue-Wei Zhao ◽  
Hong-Mei Li ◽  
Ling-Huan Gao ◽  
Rong-Tao Li
Keyword(s):  
Triterpenoid Saponins ◽  
Aerial Parts ◽  
Oleanane Triterpenoid
Sign in / Sign up

Export Citation Format

Share Document