Extraction and purification of ferulic acid from flax shives, wheat and corn bran by alkaline hydrolysis and pressurised solvents

This work aims to develop simpler methodologies of extracting ferulic acid (FA) from brewer’s spent grain (BSG). BSG is produced by brewing companies at high amounts all over the year and does not possess a direct application. Thus, its use as raw material for extraction of bioactive compounds has gained attention in the last years. FA has different interesting applications in cosmetics, food industry, and pharmaceutics. Several studies aim for its extraction from BSG by various methods, namely alkaline hydrolysis. In the present work, we suggest the use of autoclave to process higher amounts of BSG in a lab scale. A simplification of the regular post-hydrolysis procedures is also proposed to decrease the number of experimental steps and energy costs and to simultaneously increase the extraction yield (up to 470 mg of FA per 100 g of BSG). The adsorption of extracted FA in a synthetic resin is suggested as a partial purification method.

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Oxidative cross-linking of corn bran hemicellulose: formation of ferulic acid dehydrodimers

Carbohydrate Research ◽

10.1016/s0008-6215(97)00193-6 ◽

1997 ◽

Vol 303 (4) ◽

pp. 459-462 ◽

Cited By ~ 40

Author(s):

Annie Ng ◽

Rod N. Greenshields ◽

Keith W. Waldron

Keyword(s):

Ferulic Acid ◽

Cross Linking ◽

Corn Bran

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Preparation of Ferulic Acid from Agricultural Wastes: Its Improved Extraction and Purification

Journal of Agricultural and Food Chemistry ◽

10.1021/jf801536t ◽

2008 ◽

Vol 56 (17) ◽

pp. 7644-7648 ◽

Cited By ~ 69

Author(s):

Ashwini Tilay ◽

Mahesh Bule ◽

Jyoti Kishenkumar ◽

Uday Annapure

Keyword(s):

Ferulic Acid ◽

Agricultural Wastes ◽

Extraction And Purification

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Comprehensive evaluation of combining hydrothermal pretreatment (autohydrolysis) with enzymatic hydrolysis for efficient release of monosaccharides and ferulic acid from corn bran

Industrial Crops and Products ◽

10.1016/j.indcrop.2018.01.047 ◽

2018 ◽

Vol 113 ◽

pp. 348-357 ◽

Cited By ~ 10

Author(s):

Kankan Jiang ◽

Lulu Li ◽

Liangkun Long ◽

Shaojun Ding

Keyword(s):

Enzymatic Hydrolysis ◽

Ferulic Acid ◽

Comprehensive Evaluation ◽

Hydrothermal Pretreatment ◽

Corn Bran

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Inhibition of Intestinalα-Glucosidase and Glucose Absorption by Feruloylated Arabinoxylan Mono- and Oligosaccharides from Corn Bran and Wheat Aleurone

Journal of Nutrition and Metabolism ◽

10.1155/2016/1932532 ◽

2016 ◽

Vol 2016 ◽

pp. 1-9 ◽

Cited By ~ 23

Author(s):

Lovemore Nkhata Malunga ◽

Peter Eck ◽

Trust Beta

Keyword(s):

Xenopus Laevis ◽

Ferulic Acid ◽

Glucose Transporter ◽

Diabetes Management ◽

Inhibitory Effect ◽

Glucose Absorption ◽

Degree Of Polymerization ◽

Acetone Powder ◽

Corn Bran ◽

Glucose Transporter 2

The effect of feruloylated arabinoxylan mono- and oligosaccharides (FAXmo) on mammalianα-glucosidase and glucose transporters was investigated using human Caco-2 cells, rat intestinal acetone powder, andXenopus laevisoocytes. The isolated FAXmo from wheat aleurone and corn bran were identified to have degree of polymerization (DP) of 4 and 1, respectively, by HPLC-MS. Both FAXmo extracts were effective inhibitors of sucrase and maltase functions of theα-glucosidase. The IC50 for FAXmo extracts on Caco-2 cells and rat intestinalα-glucosidase was 1.03–1.65 mg/mL and 2.6–6.5 mg/mL, respectively. Similarly, glucose uptake in Caco-2 cells was inhibited up to 40%. The inhibitory effect of FAXmo was dependent on their ferulic acid (FA) content (R= 0.95). Sodium independent glucose transporter 2 (GLUT2) activity was completely inhibited by FAXmo in oocytes injected to express GLUT2. Our results suggest that ferulic acid and feruloylated arabinoxylan mono-/oligosaccharides have potential for use in diabetes management.

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