In vitro model to correlate viscosity and bile acid-binding capacity of digested water-soluble and insoluble dietary fibres

Myospherulosis is a submucosal inflammatory condition that has been linked to the use of petrolatum-based ointment in the sinus cavities of patients after paranasal sinus surgery. To avoid this problem, several investigators have suggested using water-soluble ointments. Polyethylene glycol, a vehicle commonly used for water miscible ointments, has not been examined previously with regard to its potential to cause a myospherulotic lesion. Using an in vitro model, we confirmed the potential of petrolatum ointment to produce the myospherulotic lesion and examined the myospherulotic potential of polyethylene glycol ointment.

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Comparison of in vitro Bile Acid Binding Capacity and in vivo Hypocholesteremic Activity of Cholestyramine

Experimental Biology and Medicine ◽

10.3181/00379727-121-30723 ◽

1966 ◽

Vol 121 (1) ◽

pp. 153-156 ◽

Cited By ~ 9

Author(s):

C. H. Whiteside ◽

H. B. Fluckiger ◽

H. P. Sarett

Keyword(s):

Bile Acid ◽

Binding Capacity ◽

Bile Acid Binding

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In Vitro Bile Acid Binding Capacity of Wheat Bran with Different Particle Sizes

Cereal Chemistry ◽

10.1094/cchem-08-16-0211-r ◽

2017 ◽

Vol 94 (4) ◽

pp. 654-658 ◽

Cited By ~ 3

Author(s):

Chun-yan Li ◽

Andrew L. Mense ◽

Lauren R. Brewer ◽

Chuan Lau ◽

Yong-Cheng Shi

Keyword(s):

Bile Acid ◽

Wheat Bran ◽

Binding Capacity ◽

Particle Sizes ◽

Bile Acid Binding

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Dietary fibre and sterol metabolism in the rat

British Journal Of Nutrition ◽

10.1079/bjn19740096 ◽

1974 ◽

Vol 32 (2) ◽

pp. 447-455 ◽

Cited By ~ 27

Author(s):

B. Morgan ◽

Monique Heald ◽

Sandra D. Atkin ◽

J. Green ◽

E. B. Chain

Keyword(s):

Bile Acid ◽

Dietary Fibre ◽

Synthetic Fibre ◽

Binding Capacity ◽

Sterol Metabolism ◽

Cholesterol Levels ◽

Lignin Fraction ◽

Bile Acid Binding ◽

Hepatic Synthesis

1. Sterol metabolism was studied in rats fed on a semi-synthetic fibre-free diet and in rats fed on diets containing cellulose (200 or 100 g/kg) or sugar-cane fibre (bagasse) at the same levels.2. Rats fed on the diets containing cellulose or bagasse produced significantly greater quantities of faeces than did rats fed on the fibre-free diet.3. Rats given bagasse excreted more bile acid and more neutral sterol in their faeces than did rats fed on cellulose or on the fibre-free diet.4. After 28 d, hepatic synthesis of cholesterol (from acetate) and cholesterol 7α-hydroxylase activity were significantly higher in animals fed on bagasse than in animals fed on the other two diets.5. No significant differences in serum cholesterol levels were seen in rats fed on any of the three diets.6. Food consumption was not substantially altered by the inclusion of bagasse or cellulose in the diets, although the efficiency of foodstuff utilization was generally lower.7. Bagasse adsorbed substantial quantities of cholic acid in vitro, whereas cellulose did not. The lignin fraction prepared from bagasse contributed only slightly to the total bile acid-binding capacity of bagasse.8. The results are discussed in the light of possible effects of dietary fibre on sterol metabolism in man.

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Non-extractable polyphenols and in vitro bile acid-binding capacity of dried persimmon (Diospyros kaki) fruit

Food Chemistry ◽

10.1016/j.foodchem.2019.04.092 ◽

2019 ◽

Vol 293 ◽

pp. 127-133 ◽

Cited By ~ 11

Author(s):

Yasunori Hamauzu ◽

Jutalak Suwannachot

Keyword(s):

Bile Acid ◽

Binding Capacity ◽

Diospyros Kaki ◽

Bile Acid Binding

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In Vitro Antithrombotic and Hypocholesterolemic Activities of Milk Fermented with Specific Strains of Lactococcus lactis

Nutrients ◽

10.3390/nu11092150 ◽

2019 ◽

Vol 11 (9) ◽

pp. 2150 ◽

Cited By ~ 1

Author(s):

Miguel Ángel Rendon-Rosales ◽

María J. Torres-Llanez ◽

Aarón F. González-Córdova ◽

Adrián Hernández-Mendoza ◽

Miguel A. Mazorra-Manzano ◽

...

Keyword(s):

Bile Acid ◽

Lactococcus Lactis ◽

Binding Capacity ◽

Biological Activities ◽

Fermented Milk ◽

Water Soluble ◽

Gastrointestinal Digestion ◽

Simulated Gastrointestinal Digestion ◽

Bile Acid Binding ◽

Micellar Solubility

Milk fermented with specific lactic acid bacteria (LAB) was reported to be a rich source of metabolites, such as peptides with different biological activities that may have a positive effect on cardiovascular health. Thus, in this study, the antithrombotic and hypocholesterolemic activities of fermented milk with specific strains of Lactococcus lactis were investigated before and after exposure to a simulated gastrointestinal digestion (SGD) model. The inhibition of thrombin-induced fibrin polymerization (IC50 peptide concentration necessary to inhibit thrombin activity by 50%), anticoagulant activity, inhibition of micellar solubility of cholesterol and bile acid binding capacity of water soluble fractions (WSF) <3 kDa from fermented milk were evaluated. Results indicated that the WSF from fermented milk with Lc-572 showed antithrombotic (IC50 = 0.049 mg/mL) and hypocholesterolemic (55% inhibition of micellar solubility of cholesterol and 27% bile acid binding capacity) activities. Meanwhile, fermented milk with Lc-571 showed mainly antithrombotic activity (IC50 = 0.045 mg/mL). On the other hand, fermented milk with Lc-600 presented mainly hypocholesterolemic activity (31.4% inhibition of micellar solubility of and 70% bile acid binding capacity). Moreover, biological activities were not lost after simulated gastrointestinal digestion conditions. Thus, fermented milk with these specific L. lactis strains show potential for the development of functional foods.

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