scholarly journals Systematic analytical characterization of new psychoactive substances: A case study

2016 ◽  
Vol 265 ◽  
pp. 107-115 ◽  
Author(s):  
Joana Lobo Vicente ◽  
Hubert Chassaigne ◽  
Margaret V. Holland ◽  
Fabiano Reniero ◽  
Kamil Kolář ◽  
...  
Keyword(s):  
New Psychoactive Substances ◽  
Psychoactive Substances ◽  
Analytical Characterization

Rapid pre-filtering of amphetamine and derivatives by direct analysis in real time (DART)-differential mobility spectrometry (DMS)

2017 ◽  
Vol 9 (34) ◽  
pp. 5044-5051 ◽  
Author(s):  
Ifeoluwa Ayodeji ◽  
Timothy Vazquez ◽  
Ronelle Bailey ◽  
Theresa Evans-Nguyen
Keyword(s):  
Real Time ◽  
Direct Analysis ◽  
Differential Mobility Spectrometry ◽  
New Psychoactive Substances ◽  
Psychoactive Substances ◽  
Differential Mobility ◽  
Rapid Separation

Herein, DART ionization was coupled to DMS to demonstrate their combined utility and compatibility for rapid separation and characterization of new psychoactive substances.

Crystallographic characterization of three cathinone hydrochlorides new on the NPS market: 1-(4-methylphenyl)-2-(pyrrolidin-1-yl)hexan-1-one (4-MPHP), 4-methyl-1-phenyl-2-(pyrrolidin-1-yl)pentan-1-one (α-PiHP) and 2-(methylamino)-1-(4-methylphenyl)pentan-1-one (4-MPD)

2022 ◽  
Vol 78 (1) ◽  
Author(s):  
Marcin Rojkiewicz ◽  
Piotr Kuś ◽  
Maria Książek ◽  
Joachim Kusz
Keyword(s):  
Chemical Structure ◽  
Crystallographic Data ◽  
New Psychoactive Substances ◽  
Monoclinic Space Group ◽  
Psychoactive Substances ◽  
Space Group ◽  
X Ray ◽  
X Ray Crystallography ◽  
Analytical Laboratories

Cathinones belong to a group of compounds of great interest in the new psychoactive substances (NPS) market. Constant changes to the chemical structure made by the producers of these compounds require a quick reaction from analytical laboratories in ascertaining their characteristics. In this article, three cathinone derivatives were characterized by X-ray crystallography. The investigated compounds were confirmed as: 1-[1-(4-methylphenyl)-1-oxohexan-2-yl]pyrrolidin-1-ium chloride (1, C17H26NO+·Cl−, the hydrochloride of 4-MPHP), 1-(4-methyl-1-oxo-1-phenylpentan-2-yl)pyrrolidin-1-ium chloride (2; C16H24NO+·Cl−, the hydrochloride of α-PiHP) and methyl[1-(4-methylphenyl)-1-oxopentan-2-yl]azanium chloride (3; C13H20NO+·Cl−, the hydrochloride of 4-MPD). All the salts crystallize in a monoclinic space group: 1 and 2 in P21/c, and 3 in P21/n. To the best of our knowledge, this study provides the first detailed and comprehensive crystallographic data on salts 1–3.

scholarly journals In vitro functional characterization of a panel of non-fentanyl opioid new psychoactive substances

2020 ◽  
Vol 94 (11) ◽  
pp. 3819-3830 ◽  
Author(s):  
Marthe M. Vandeputte ◽  
Annelies Cannaert ◽  
Christophe P. Stove
Keyword(s):  
Functional Characterization ◽  
New Psychoactive Substances ◽  
Psychoactive Substances

scholarly journals Crystal Structures and Spectroscopic Characterization of Four Synthetic Cathinones: 1-(4-Chlorophenyl)-2-(Dimethylamino)Propan-1-One (N-Methyl-Clephedrone, 4-CDC), 1-(1,3-Benzodioxol-5-yl)-2-(Tert-Butylamino)Propan-1-One (tBuONE, Tertylone, MDPT), 1-(4-Fluorophenyl)-2-(Pyrrolidin-1-yl)Hexan-1-One (4F-PHP) and 2-(Ethylamino)-1-(3-Methylphenyl)Propan-1-One (3-Methyl-Ethylcathinone, 3-MEC)

Crystals ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. 555 ◽  
Author(s):  
Marta Siczek ◽  
Miłosz Siczek ◽  
Paweł Szpot ◽  
Marcin Zawadzki ◽  
Olga Wachełko
Keyword(s):  
Chemical Structure ◽  
Drug Market ◽  
Spectroscopic Characterization ◽  
Synthetic Cathinones ◽  
New Psychoactive Substances ◽  
Psychoactive Substances ◽  
X Ray ◽  
Similar Chemical ◽  
Solution Nuclear Magnetic Resonance

Every year new synthetic cathinones are flooding the European drug market. They gain more and more popularity in place of cathinones that became illegal. Compounds from both groups, “classic” and “new” cathinones, have a similar chemical structure and, as a consequence, their psychoactive properties are not much different. Cathinone analogs were secured by the police during the search of a suspect’s apartment. The aim of this paper was to present results of analyses and identification of these synthetic cathinones. The structure of new psychoactive substances (NPS) was identified by single-crystal X-ray analysis, solution nuclear magnetic resonance (NMR), UHPLC-QQQ-MS/MS and GC-MS.

scholarly journals High-field and benchtop NMR spectroscopy for the characterization of new psychoactive substances

2021 ◽  
Vol 321 ◽  
pp. 110718
Author(s):  
Thomas Castaing-Cordier ◽  
Virginie Ladroue ◽  
Fabrice Besacier ◽  
Audrey Bulete ◽  
Denis Jacquemin ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
High Field ◽  
New Psychoactive Substances ◽  
Psychoactive Substances
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