scholarly journals Comprehensive Protocol for the Identification and Characterization of New Psychoactive Substances in the Service of Law Enforcement Agencies

2020 ◽  
Vol 8 ◽  
Author(s):  
Ewa Bulska ◽  
Robert Bachliński ◽  
Michał K. Cyrański ◽  
Magdalena Michalska-Kacymirow ◽  
Wioletta Kośnik ◽  
...  
Keyword(s):  
Law Enforcement ◽  
New Psychoactive Substances ◽  
Psychoactive Substances ◽  
Law Enforcement Agencies ◽  
Identification And Characterization

Rapid pre-filtering of amphetamine and derivatives by direct analysis in real time (DART)-differential mobility spectrometry (DMS)

2017 ◽  
Vol 9 (34) ◽  
pp. 5044-5051 ◽  
Author(s):  
Ifeoluwa Ayodeji ◽  
Timothy Vazquez ◽  
Ronelle Bailey ◽  
Theresa Evans-Nguyen
Keyword(s):  
Real Time ◽  
Direct Analysis ◽  
Differential Mobility Spectrometry ◽  
New Psychoactive Substances ◽  
Psychoactive Substances ◽  
Differential Mobility ◽  
Rapid Separation

Herein, DART ionization was coupled to DMS to demonstrate their combined utility and compatibility for rapid separation and characterization of new psychoactive substances.

Crystallographic characterization of three cathinone hydrochlorides new on the NPS market: 1-(4-methylphenyl)-2-(pyrrolidin-1-yl)hexan-1-one (4-MPHP), 4-methyl-1-phenyl-2-(pyrrolidin-1-yl)pentan-1-one (α-PiHP) and 2-(methylamino)-1-(4-methylphenyl)pentan-1-one (4-MPD)

2022 ◽  
Vol 78 (1) ◽  
Author(s):  
Marcin Rojkiewicz ◽  
Piotr Kuś ◽  
Maria Książek ◽  
Joachim Kusz
Keyword(s):  
Chemical Structure ◽  
Crystallographic Data ◽  
New Psychoactive Substances ◽  
Monoclinic Space Group ◽  
Psychoactive Substances ◽  
Space Group ◽  
X Ray ◽  
X Ray Crystallography ◽  
Analytical Laboratories

Cathinones belong to a group of compounds of great interest in the new psychoactive substances (NPS) market. Constant changes to the chemical structure made by the producers of these compounds require a quick reaction from analytical laboratories in ascertaining their characteristics. In this article, three cathinone derivatives were characterized by X-ray crystallography. The investigated compounds were confirmed as: 1-[1-(4-methylphenyl)-1-oxohexan-2-yl]pyrrolidin-1-ium chloride (1, C17H26NO+·Cl−, the hydrochloride of 4-MPHP), 1-(4-methyl-1-oxo-1-phenylpentan-2-yl)pyrrolidin-1-ium chloride (2; C16H24NO+·Cl−, the hydrochloride of α-PiHP) and methyl[1-(4-methylphenyl)-1-oxopentan-2-yl]azanium chloride (3; C13H20NO+·Cl−, the hydrochloride of 4-MPD). All the salts crystallize in a monoclinic space group: 1 and 2 in P21/c, and 3 in P21/n. To the best of our knowledge, this study provides the first detailed and comprehensive crystallographic data on salts 1–3.

scholarly journals Systematic analytical characterization of new psychoactive substances: A case study

2016 ◽  
Vol 265 ◽  
pp. 107-115 ◽  
Author(s):  
Joana Lobo Vicente ◽  
Hubert Chassaigne ◽  
Margaret V. Holland ◽  
Fabiano Reniero ◽  
Kamil Kolář ◽  
...  
Keyword(s):  
New Psychoactive Substances ◽  
Psychoactive Substances ◽  
Analytical Characterization

scholarly journals FORENSICS CHARACTERISTICS IN THE STRUCTURE OF THE CRIME INVESTIGATION METHODOLOGY

2021 ◽  
pp. 228-243
Author(s):  
Е. Lukianchykov ◽  
B. Lukianchykov ◽  
S. Petriaiev
Keyword(s):  
Law Enforcement ◽  
Forensic Science ◽  
Cognitive Activity ◽  
Law Enforcement Agencies ◽  
Structural Element ◽  
Historical Aspect ◽  
Stage Of Development ◽  
The Subject ◽  
Qualitative Changes

The article deals with the problematic issues of the forensics characteristics of crimes as a scientific category of forensic science and tools of cognitive activity in the disclosure and investigation of crimes. Attention is drawn to the fact that the modern stage of development of society is characterized not only by quantitative, but also by qualitative changes in the state of crime. New types of crimes are appearing and traditional methods of their commission and concealment are being improved using the achievements of scientific and technological progress. Significant parts of the crimes remain unsolved, and the persons who committed them are not punished. Law enforcement agencies are faced with the task of quickly disclosing them and protecting the violated rights of victims. Science, primarily forensic science, is called upon to provide assistance in solving such problems. In the historical aspect, the development of the theory of forensic methodology, determining its place in the system of forensic science is considered. It is noted that it is advisable to consider the forensic methodology both as a branch of science, and as a system of knowledge about the technology of investigating crimes, and the technology itself, a kind of algorithm for investigating crimes, which is implemented in the practical activities of investigators, detectives, prosecutors. Attention is drawn to the fact that since the mid-80s of the last century, the concept of criminalistics characteristics of crimes has entered the scientific circulation. Its correlation with the subject of proof and the opinions of scientists and practitioners about the place of forensic characteristics in the structure of private methods of investigation of certain types of crimes are analyzed. Based on the analysis, the author substantiates the conclusion that the forensic characterization of crimes should be considered as a structural element of a private investigation methodology and the basis for the development of such methods. Attention is drawn to the mandatory study of the correlation dependences between its elements, which can serve as a key to disclosing a specific crime.

scholarly journals In vitro functional characterization of a panel of non-fentanyl opioid new psychoactive substances

2020 ◽  
Vol 94 (11) ◽  
pp. 3819-3830 ◽  
Author(s):  
Marthe M. Vandeputte ◽  
Annelies Cannaert ◽  
Christophe P. Stove
Keyword(s):  
Functional Characterization ◽  
New Psychoactive Substances ◽  
Psychoactive Substances

scholarly journals Automatic identification of NBOMe illicit psychoactive substances based on combined molecular descriptors

2021 ◽  
Vol 342 ◽  
pp. 05008
Author(s):  
Adelina Ion ◽  
Mirela Praisler ◽  
Catalina Mercedes Burlacu ◽  
Nicolae Catalin Stanica
Keyword(s):  
Parent Compound ◽  
Classification Performance ◽  
Molecular Structures ◽  
New Psychoactive Substances ◽  
Automatic Identification ◽  
Psychoactive Substances ◽  
Law Enforcement Agencies ◽  
Synthetic Derivative ◽  
Input Variables ◽  
Very High

During the last decade, a growing prevalence of new psychoactive substances (NPS) has been noticed by the law enforcement agencies. Although NPS have no medical use due to their very high toxicity, they are often sold on the black market. NBOMe defines a group of toxic amphetamines that has as parent compound 25I-NBOMe, a synthetic derivative of 2C-I (2,5-dimethoxy-4-iodophenetylamine). In this paper, we are presenting a series of Artificial Neural Networks (ANNs) designed to identify the NBOMe class membership based on a mixture of topological and 3D-MoRSE descriptors. For this purpose, the molecular structures of 160 compounds representing NBOMe compounds, narcotics, sympathomimetic amines, potent analgesics, as well as their main precursors have been first optimized. Then a molecular database was formed by computing a large number of topological and 3D-MoRSE descriptors that characterize these structures. This database was used as input for building an ANN system designed to recognize NBOMes. The relevance of the input variables on its classification performance has been assessed and new systems have been built by using different combinations of selected topological and 3D-MoRSE descriptors. The best performing system has been found by comparing various classification efficiency criteria.

scholarly journals Crystal Structures and Spectroscopic Characterization of Four Synthetic Cathinones: 1-(4-Chlorophenyl)-2-(Dimethylamino)Propan-1-One (N-Methyl-Clephedrone, 4-CDC), 1-(1,3-Benzodioxol-5-yl)-2-(Tert-Butylamino)Propan-1-One (tBuONE, Tertylone, MDPT), 1-(4-Fluorophenyl)-2-(Pyrrolidin-1-yl)Hexan-1-One (4F-PHP) and 2-(Ethylamino)-1-(3-Methylphenyl)Propan-1-One (3-Methyl-Ethylcathinone, 3-MEC)

Crystals ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. 555 ◽  
Author(s):  
Marta Siczek ◽  
Miłosz Siczek ◽  
Paweł Szpot ◽  
Marcin Zawadzki ◽  
Olga Wachełko
Keyword(s):  
Chemical Structure ◽  
Drug Market ◽  
Spectroscopic Characterization ◽  
Synthetic Cathinones ◽  
New Psychoactive Substances ◽  
Psychoactive Substances ◽  
X Ray ◽  
Similar Chemical ◽  
Solution Nuclear Magnetic Resonance

Every year new synthetic cathinones are flooding the European drug market. They gain more and more popularity in place of cathinones that became illegal. Compounds from both groups, “classic” and “new” cathinones, have a similar chemical structure and, as a consequence, their psychoactive properties are not much different. Cathinone analogs were secured by the police during the search of a suspect’s apartment. The aim of this paper was to present results of analyses and identification of these synthetic cathinones. The structure of new psychoactive substances (NPS) was identified by single-crystal X-ray analysis, solution nuclear magnetic resonance (NMR), UHPLC-QQQ-MS/MS and GC-MS.

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