Analysis of mitochondrial ROS production and response to induced oxidative stress in normal human dermal fibroblasts: Comparison of different detection methods

2012 ◽  
Vol 53 ◽  
pp. S201-S202
Author(s):  
P. Fernandez-Guerra⁎ ◽  
J. Palmfeldt ◽  
P. Bross
Keyword(s):  
Oxidative Stress ◽  
Dermal Fibroblasts ◽  
Detection Methods ◽  
Ros Production ◽  
Human Dermal Fibroblasts ◽  
Mitochondrial Ros ◽  
Normal Human ◽  
Normal Human Dermal Fibroblasts

scholarly journals Inonotus obliquus Extracts Decreased Expression of MMP1 mRNA via JNK-AP-1 Axis

Cosmetics ◽  
2020 ◽  
Vol 7 (2) ◽  
pp. 36
Author(s):  
Young Joo Kim ◽  
Hwa Jun Cha
Keyword(s):  
Oxidative Stress ◽  
Matrix Metalloproteinases ◽  
Mrna Expression ◽  
Transcriptional Activity ◽  
Dermal Fibroblasts ◽  
Human Dermal Fibroblasts ◽  
Inonotus Obliquus ◽  
The Family ◽  
Normal Human ◽  
Normal Human Dermal Fibroblasts

Inonotus obliquus, which is parasitic on birch and other trees, is a fungus in the family Hymenochaetaceae. In this study, we investigated whether Inonotus obliquus extracts used in traditional medicine were decreased in the expression of matrix metalloproteinases-1 (MMP-1) in the normal human dermal fibroblasts. As shown in our results, extracts of Inonotus obliquus decreased MMP1 expression in oxidative stress-exposed normal human dermal fibroblasts. Additionally, Inonotus obliquus extracts decreased AP-1 transcriptional activity and phospho-JNK in oxidative stress-exposed normal human dermal fibroblasts. Oxidative stress mediated the elevation of MMP1 mRNA expression and was well regulated by the JNK-AP-1 axis. Therefore, the results suggest that Inonotus obliquus extracts decreased MMP1 mRNA expression by regulating JNK-AP-1 axis. Additionally, Inonotus obliquus extracts have the potential to reduce collagen destruction and the formation of wrinkles and to be used as a cosmetic ingredient.

Silymarin and silybin in suppression of UVA-induced oxidative stress in normal human dermal fibroblasts

2017 ◽  
Vol 108 ◽  
pp. S76
Author(s):  
Alena Rajnochová Svobodová ◽  
Eva Gabrielová ◽  
Jitka Ulrichová ◽  
Bohumil Zálešák ◽  
Jitka Vostálová
Keyword(s):  
Oxidative Stress ◽  
Dermal Fibroblasts ◽  
Human Dermal Fibroblasts ◽  
Normal Human ◽  
Normal Human Dermal Fibroblasts

scholarly journals Inonotus Obliquus Extracts Decreased Expression of MMP1 mRNA via JNK-AP-1 Axis

2020 ◽  
Author(s):  
Young Joo Kim ◽  
Hwa Jun Cha
Keyword(s):  
Oxidative Stress ◽  
Matrix Metalloproteinases ◽  
Traditional Medicine ◽  
Transcriptional Activity ◽  
Dermal Fibroblasts ◽  
Human Dermal Fibroblasts ◽  
Inonotus Obliquus ◽  
Normal Human ◽  
Normal Human Dermal Fibroblasts

In present study, the effect of Inonotus Obliquus extracts used in traditional medicine was investigated on the expression of matrix metalloproteinases-1 (MMP-1) in the normal human dermal fibroblasts. As shown our results, extracts of Inonotus Obliquus decreased MMP1 expression in oxidative stress-exposed normal human dermal fibroblasts. Additionally, Inonotus Obliquus extracts decreased AP-1 transcriptional activity and phospho-JNK in oxidative stress exposed normal human dermal fibroblasts. The results suggest that Inonotus Obliquus extracts decreased MMP1 expression using decreasing AP-1 transcriptional activity and phospho-JNK. Therefore, Inonotus Obliquus extracts has potential to reduce formation of wrinkle and to use as a cosmetic ingredient.

scholarly journals Effects of GABA on the expression of type I collagen gene in normal human dermal fibroblasts

2016 ◽  
Vol 81 (2) ◽  
pp. 376-379 ◽  
Author(s):  
Eriko Uehara ◽  
Hideki Hokazono ◽  
Takako Sasaki ◽  
Hidekatsu Yoshioka ◽  
Noritaka Matsuo
Keyword(s):  
Type I Collagen ◽  
Dermal Fibroblasts ◽  
Type I ◽  
Collagen Gene ◽  
Human Dermal Fibroblasts ◽  
Normal Human ◽  
Normal Human Dermal Fibroblasts
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